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Kinetochore-microtubule interactions

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Kinetochore-microtubule interactions : steps towards bi-orientation. / Tanaka, Tomoyuki U.

In: EMBO Journal, Vol. 29, No. 24, 15.12.2010, p. 4070-4082.

Research output: Contribution to journalScientific review

Harvard

Tanaka, TU 2010, 'Kinetochore-microtubule interactions: steps towards bi-orientation' EMBO Journal, vol 29, no. 24, pp. 4070-4082., 10.1038/emboj.2010.294

APA

Tanaka, T. U. (2010). Kinetochore-microtubule interactions: steps towards bi-orientation. EMBO Journal, 29(24), 4070-4082. 10.1038/emboj.2010.294

Vancouver

Tanaka TU. Kinetochore-microtubule interactions: steps towards bi-orientation. EMBO Journal. 2010 Dec 15;29(24):4070-4082. Available from: 10.1038/emboj.2010.294

Author

Tanaka, Tomoyuki U. / Kinetochore-microtubule interactions : steps towards bi-orientation.

In: EMBO Journal, Vol. 29, No. 24, 15.12.2010, p. 4070-4082.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{b28e48d094144f17901cb33b368b258f,
title = "Kinetochore-microtubule interactions: steps towards bi-orientation",
keywords = "bi-orientation, chromosome segregation, kinetochore, microtubule, mitosis, SPINDLE-ASSEMBLY CHECKPOINT, BIPOLAR CHROMOSOME ATTACHMENT, NEWT LUNG-CELLS, AURORA-B, MITOTIC-SPINDLE, FISSION YEAST, BUDDING YEAST, SACCHAROMYCES-CEREVISIAE, OUTER KINETOCHORE, NDC80 COMPLEX",
author = "Tanaka, {Tomoyuki U.}",
year = "2010",
doi = "10.1038/emboj.2010.294",
volume = "29",
number = "24",
pages = "4070--4082",
journal = "EMBO Journal",
issn = "0261-4189",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Kinetochore-microtubule interactions

T2 - steps towards bi-orientation

A1 - Tanaka,Tomoyuki U.

AU - Tanaka,Tomoyuki U.

PY - 2010/12/15

Y1 - 2010/12/15

N2 - <p>Eukaryotic cells segregate their chromosomes accurately to opposite poles during mitosis, which is necessary for maintenance of their genetic integrity. This process mainly relies on the forces generated by kinetochore-microtubule (KT-MT) attachment. During prometaphase, the KT initially interacts with a single MT extending from a spindle pole and then moves towards a spindle pole. Subsequently, MTs from the other spindle pole also interact with the KT. Eventually, one sister KT becomes attached to MTs from one pole while the other sister to those from the other pole (sister KT bi-orientation). If sister KTs interact with MTs with aberrant orientation, this must be corrected to attain proper bi-orientation (error correction) before the anaphase is initiated. Here, I discuss how KTs initially interact with MTs and how this interaction develops into bi-orientation; both processes are fundamentally crucial for proper chromosome segregation in the subsequent anaphase. The EMBO Journal (2010) 29, 4070-4082. doi: 10.1038/emboj.2010.294; Published online 23 November 2010</p>

AB - <p>Eukaryotic cells segregate their chromosomes accurately to opposite poles during mitosis, which is necessary for maintenance of their genetic integrity. This process mainly relies on the forces generated by kinetochore-microtubule (KT-MT) attachment. During prometaphase, the KT initially interacts with a single MT extending from a spindle pole and then moves towards a spindle pole. Subsequently, MTs from the other spindle pole also interact with the KT. Eventually, one sister KT becomes attached to MTs from one pole while the other sister to those from the other pole (sister KT bi-orientation). If sister KTs interact with MTs with aberrant orientation, this must be corrected to attain proper bi-orientation (error correction) before the anaphase is initiated. Here, I discuss how KTs initially interact with MTs and how this interaction develops into bi-orientation; both processes are fundamentally crucial for proper chromosome segregation in the subsequent anaphase. The EMBO Journal (2010) 29, 4070-4082. doi: 10.1038/emboj.2010.294; Published online 23 November 2010</p>

KW - bi-orientation

KW - chromosome segregation

KW - kinetochore

KW - microtubule

KW - mitosis

KW - SPINDLE-ASSEMBLY CHECKPOINT

KW - BIPOLAR CHROMOSOME ATTACHMENT

KW - NEWT LUNG-CELLS

KW - AURORA-B

KW - MITOTIC-SPINDLE

KW - FISSION YEAST

KW - BUDDING YEAST

KW - SACCHAROMYCES-CEREVISIAE

KW - OUTER KINETOCHORE

KW - NDC80 COMPLEX

U2 - 10.1038/emboj.2010.294

DO - 10.1038/emboj.2010.294

M1 - Scientific review

JO - EMBO Journal

JF - EMBO Journal

SN - 0261-4189

IS - 24

VL - 29

SP - 4070

EP - 4082

ER -

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