Knockout and transgenic mice in glutathione transferase research. / Henderson, Colin J.; Wolf, C. Roland.
In: Drug Metabolism Reviews, Vol. 43, No. 2, 05.2011, p. 152-164.Research output: Contribution to journal › Scientific review
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TY - JOUR
T1 - Knockout and transgenic mice in glutathione transferase research
A1 - Henderson,Colin J.
A1 - Wolf,C. Roland
AU - Henderson,Colin J.
AU - Wolf,C. Roland
PY - 2011/5
Y1 - 2011/5
N2 - <p>Glutathione transferases (GSTs) are a multigene family of ubiquitously expressed, polymorphic enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates, play a central role in the adaptive response to chemical and oxidative stress, and are subject to regulation by a range of structurally unrelated chemicals. In this review, we present a current summary of knockout mouse models in the GST field, discussing some of the issues pertaining to orthologous proteins between mice and humans, the potential confounding issues related to genetic background, and also cover new transgenic models in the increasingly important area of humanization.</p>
AB - <p>Glutathione transferases (GSTs) are a multigene family of ubiquitously expressed, polymorphic enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates, play a central role in the adaptive response to chemical and oxidative stress, and are subject to regulation by a range of structurally unrelated chemicals. In this review, we present a current summary of knockout mouse models in the GST field, discussing some of the issues pertaining to orthologous proteins between mice and humans, the potential confounding issues related to genetic background, and also cover new transgenic models in the increasingly important area of humanization.</p>
KW - Glutathione transferase
KW - transgenic
KW - knockout
KW - humanization
KW - PREGNANE-X-RECEPTOR
KW - AGE-AT-ONSET
KW - CONSTITUTIVE ANDROSTANE RECEPTOR
KW - DRUG-METABOLIZING-ENZYMES
KW - GST-PI EXPRESSION
KW - S-TRANSFERASE
KW - OMEGA-CLASS
KW - FUNCTIONAL-CHARACTERIZATION
KW - SACCHAROMYCES-CEREVISIAE
KW - HETEROLOGOUS EXPRESSION
U2 - 10.3109/03602532.2011.562900
DO - 10.3109/03602532.2011.562900
M1 - Scientific review
JO - Drug Metabolism Reviews
JF - Drug Metabolism Reviews
SN - 0360-2532
IS - 2
VL - 43
SP - 152
EP - 164
ER -