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Knockout and transgenic mice in glutathione transferase research

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Knockout and transgenic mice in glutathione transferase research. / Henderson, Colin J.; Wolf, C. Roland.

In: Drug Metabolism Reviews, Vol. 43, No. 2, 05.2011, p. 152-164.

Research output: Contribution to journalScientific review

Harvard

Henderson, CJ & Wolf, CR 2011, 'Knockout and transgenic mice in glutathione transferase research' Drug Metabolism Reviews, vol 43, no. 2, pp. 152-164.

APA

Henderson, C. J., & Wolf, C. R. (2011). Knockout and transgenic mice in glutathione transferase research. Drug Metabolism Reviews, 43(2), 152-164doi: 10.3109/03602532.2011.562900

Vancouver

Henderson CJ, Wolf CR. Knockout and transgenic mice in glutathione transferase research. Drug Metabolism Reviews. 2011 May;43(2):152-164.

Author

Henderson, Colin J.; Wolf, C. Roland / Knockout and transgenic mice in glutathione transferase research.

In: Drug Metabolism Reviews, Vol. 43, No. 2, 05.2011, p. 152-164.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{9c1f3de2b55041a09b9e00af8e49749a,
title = "Knockout and transgenic mice in glutathione transferase research",
author = "Henderson, {Colin J.} and Wolf, {C. Roland}",
year = "2011",
volume = "43",
number = "2",
pages = "152--164",
journal = "Drug Metabolism Reviews",
issn = "0360-2532",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Knockout and transgenic mice in glutathione transferase research

A1 - Henderson,Colin J.

A1 - Wolf,C. Roland

AU - Henderson,Colin J.

AU - Wolf,C. Roland

PY - 2011/5

Y1 - 2011/5

N2 - <p>Glutathione transferases (GSTs) are a multigene family of ubiquitously expressed, polymorphic enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates, play a central role in the adaptive response to chemical and oxidative stress, and are subject to regulation by a range of structurally unrelated chemicals. In this review, we present a current summary of knockout mouse models in the GST field, discussing some of the issues pertaining to orthologous proteins between mice and humans, the potential confounding issues related to genetic background, and also cover new transgenic models in the increasingly important area of humanization.</p>

AB - <p>Glutathione transferases (GSTs) are a multigene family of ubiquitously expressed, polymorphic enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates, play a central role in the adaptive response to chemical and oxidative stress, and are subject to regulation by a range of structurally unrelated chemicals. In this review, we present a current summary of knockout mouse models in the GST field, discussing some of the issues pertaining to orthologous proteins between mice and humans, the potential confounding issues related to genetic background, and also cover new transgenic models in the increasingly important area of humanization.</p>

KW - Glutathione transferase

KW - transgenic

KW - knockout

KW - humanization

KW - PREGNANE-X-RECEPTOR

KW - AGE-AT-ONSET

KW - CONSTITUTIVE ANDROSTANE RECEPTOR

KW - DRUG-METABOLIZING-ENZYMES

KW - GST-PI EXPRESSION

KW - S-TRANSFERASE

KW - OMEGA-CLASS

KW - FUNCTIONAL-CHARACTERIZATION

KW - SACCHAROMYCES-CEREVISIAE

KW - HETEROLOGOUS EXPRESSION

U2 - 10.3109/03602532.2011.562900

DO - 10.3109/03602532.2011.562900

M1 - Scientific review

JO - Drug Metabolism Reviews

JF - Drug Metabolism Reviews

SN - 0360-2532

IS - 2

VL - 43

SP - 152

EP - 164

ER -

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