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Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

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Authors

  • Blair Smith
  • Patrick T. Ellinor (Lead / Corresponding author)

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Original languageEnglish
JournalNature Genetics
Early online date17 Apr 2017
DOIs
StateE-pub ahead of print - 17 Apr 2017

Abstract

Atrial fibrillation (AF) affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death.1,2 Fourteen genetic loci have been associated with AF in European and Asian ancestry groups.3–7 To further define the genetic basis of AF, we performed large-scale, multi-racial meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 18,398 individuals with AF and 91,536 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,806 cases and 132,612 referents. We identified 12 novel genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for AF, provide insights into the molecular basis of AF, and may facilitate new potential targets for drug discovery.

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