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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. / Scott, Robert A.; Lagou, Vasiliki; Welch, Ryan P.; Wheeler, Eleanor; Montasser, May E.; Luan, Jian'an; MäGi, Reedik; Strawbridge, Rona J.; Rehnberg, Emil; Gustafsson, Sefan; Kanoni, Stavroula; Rasmussen-Torvik, Laura J.; Yengo, Loic; Lecoeur, Cecile; Shungin, Dmitry; Sanna, Serena; Sidore, Carlo; Johnson, Paul C.D.; Jukema, J.Wouter; Johnson, Toby; Mahajan, Anubha; Verweij, Niek; Thorleifsson, Gudmar; Hottenga, Jouke Jan; Shah, Sonia; Smith, Albert V.; Sennblad, Bengt; Gieger, Christian; Salo, Perttu; Perola, Markus; Timpson, Nicholas J.; Evans, David M.; St Pourcain, Beate; Wu, Ying; Andrews, Jeanette S.; Hui, Jennie; Bielak, Lawrence F.; Zhao, Wei; Horikoshi, Momoko; Navarro, Pau; Isaacs, Aaron; O'Connell, Jeffrey R.; Stirrups, Kathleen; Vitart, Veronique; Hayward, Caroline; Esko, Tonu; Mihailov, Evelin; Fraser, Ross M.; Fall, Tove; Voight, Benjamin F.; Raychaudhuri, Soumya; Chen, Han; Lindgren, Cecilia M.; Morris, Andrew P.; Rayner, Nigel W.; Robertson, Neil; Rybin, Denis; Liu, Ching-Ti; Beckmann, Jacques S.; Willems, Sara M.; Chines, Peter S.; Jackson, Anne U.; Kang, Hyun Min; Stringham, Heather M.; Song, Kijoung; Tanaka, Toshiko; Peden, John F.; Goel, Anuj; Hicks, Andrew A.; An, Ping; Muller-Nurasyid, Martina; Franco-Cereceda, Anders; Folkersen, Lasse; Marullo, Letizia; Jansen, Hanneke; Oldehinkel, Albertine J.; Bruinenberg, Marcel; Pankow, James S.; North, Kari E.; Forouhi, Nita G.; Loos, Ruth J. F.; Edkins, Sarah; Varga, Tibor V.; Hallmans, Goran; Oksa, Heikki; Mulas, Antonella; Nagaraja, Ramaiah; Trompet, Stella; Ford, Ian; Small, Kerrin; Miljkovic, Iva; Liu, Yongmei; Atalay, Mustafa; Kiess, Wieland; James, Alan L. ; Rivadeneira, Fernando; Uitterlinden, Andre G.; Palmer, Colin N A; Doney, Alex S. F.; Willemsen, Gonneke; Smit, Johannes H.; Campbell, Susan; Polasek, Ozren; Bonnycastle, Lori L.; Hercberg, Serge; Dimitriou, Maria; Bolton, Jennifer L. ; Fowkes, Gerard R. ; Kovacs, Peter; Lindström, Jaana; Zemunik, Tatijana; Bandinelli, Stefania; Wild, Sarah H.; Basart, Hanneke V.; Rathmann, Wolfgang; Grallert, Harald; Maerz, Winfried; Kleber, Marcus E.; Boehm, Bernhard O.; Peters, Annette; Pramstaller, Peter P; Province, Michael A.; Borecki, Ingrid B.; Hastie, Nicholas D.; Rudan, Igor; Campbell, Harry; Watkins, Hugh; Farrall, Martin; Stumvoll, Michael; Ferrucci, Luigi; Waterworth, Dawn M.; Bergman, Richard N.; Collins, Francis S.; Watanabe, Richard M; Pedersen, Nancy L.; Sattar, Naveed; Harris, Tamara B.; Cucca, Francesco; Ripatti, Samuli; Salomaa, Veikko; Mohlke, Karen L.; Balkau, Beverley; Froguel, Philippe; Pouta, Anneli; Jarvelin, Marjo-Riitta; Wareham, Nicholas J.; Bouatia-Naji, Nabila; McCarthy, Mark I.; Franks, Paul W.; Meigs, James B.; Teslovich, Tanya M.; Florez, Jose C.; Tuomilehto, Jaakko; de Geus, Eco J C ; Penninx, Brenda W ; Hofman, Albert; Oostra, Ben A ; Psaty, Bruce M; Vollenweider, Peter; Wilson, James F ; Hovingh, G Kees; Wright, Alan F ; Metspalu, Andres; Uusitupa, Matti; Magnusson, Patrik K E ; Kyvik, Kirsten O ; Kaprio, Jaakko; Price, Jackie F ; Dedoussis, George V; Deloukas, Panos; Meneton, Pierre; Lind, Lars; Boehnke, Michael; Shuldiner, Alan R; van Duijn, Cornelia M ; Morris, Andrew D.; Toenjes, Anke; Peyser, Patricia A.; Beilby, John P.; Korner, Antje; Kuusisto, Johanna; Langenberg, Claudia; Ingelsson, Erik; Laakso, Markku; Bornstein, Stefan R.; Schwarz, Peter E. H.; Lakka, Timo A.; Rauramaa, Rainer; Adair, Linda S.; Smith, George Davey; Spector, Tim D.; Illig, Thomas; de Faire, Ulf; Hamsten, Anders; Gudnason, Vilmundur; Kivimaki, Mika; Hingorani, Aroon; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Boomsma, Dorret I.; van der Harst, Pim; Dupuis, Josee; Bakker, Stephan J. L.; Kong, Augustine; Gigante, Bruna; Kumari, Meena; Herder, Christian; Munroe, Patricia B.; Caulfield, Mark; Jula, Antti; Mangino, Massimo; Prokopenko, Inga; Barroso, Ines.

In: Nature Genetics, Vol. 44, No. 9, 2012, p. 991-1005.

Research output: Contribution to journal › Article

Harvard

Scott, RA, Lagou, V, Welch, RP, Wheeler, E, Montasser, ME, Luan, J, MäGi, R, Strawbridge, RJ, Rehnberg, E, Gustafsson, S, Kanoni, S, Rasmussen-Torvik, LJ, Yengo, L, Lecoeur, C, Shungin, D, Sanna, S, Sidore, C, Johnson, PCD, Jukema, JW, Johnson, T, Mahajan, A, Verweij, N, Thorleifsson, G, Hottenga, JJ, Shah, S, Smith, AV, Sennblad, B, Gieger, C, Salo, P, Perola, M, Timpson, NJ, Evans, DM, St Pourcain, B, Wu, Y, Andrews, JS, Hui, J, Bielak, LF, Zhao, W, Horikoshi, M, Navarro, P, Isaacs, A, O'Connell, JR, Stirrups, K, Vitart, V, Hayward, C, Esko, T, Mihailov, E, Fraser, RM, Fall, T, Voight, BF, Raychaudhuri, S, Chen, H, Lindgren, CM, Morris, AP, Rayner, NW, Robertson, N, Rybin, D, Liu, C-T, Beckmann, JS, Willems, SM, Chines, PS, Jackson, AU, Kang, HM, Stringham, HM, Song, K, Tanaka, T, Peden, JF, Goel, A, Hicks, AA, An, P, Muller-Nurasyid, M, Franco-Cereceda, A, Folkersen, L, Marullo, L, Jansen, H, Oldehinkel, AJ, Bruinenberg, M, Pankow, JS, North, KE, Forouhi, NG, Loos, RJF, Edkins, S, Varga, TV, Hallmans, G, Oksa, H, Mulas, A, Nagaraja, R, Trompet, S, Ford, I, Small, K, Miljkovic, I, Liu, Y, Atalay, M, Kiess, W, James, AL, Rivadeneira, F, Uitterlinden, AG, Palmer, CNA, Doney, ASF, Willemsen, G, Smit, JH, Campbell, S, Polasek, O, Bonnycastle, LL, Hercberg, S, Dimitriou, M, Bolton, JL, Fowkes, GR, Kovacs, P, Lindström, J, Zemunik, T, Bandinelli, S, Wild, SH, Basart, HV, Rathmann, W, Grallert, H, Maerz, W, Kleber, ME, Boehm, BO, Peters, A, Pramstaller, PP, Province, MA, Borecki, IB, Hastie, ND, Rudan, I, Campbell, H, Watkins, H, Farrall, M, Stumvoll, M, Ferrucci, L, Waterworth, DM, Bergman, RN, Collins, FS, Watanabe, RM, Pedersen, NL, Sattar, N, Harris, TB, Cucca, F, Ripatti, S, Salomaa, V, Mohlke, KL, Balkau, B, Froguel, P, Pouta, A, Jarvelin, M-R, Wareham, NJ, Bouatia-Naji, N, McCarthy, MI, Franks, PW, Meigs, JB, Teslovich, TM, Florez, JC, Tuomilehto, J, de Geus, EJC, Penninx, BW, Hofman, A, Oostra, BA, Psaty, BM, Vollenweider, P, Wilson, JF, Hovingh, GK, Wright, AF, Metspalu, A, Uusitupa, M, Magnusson, PKE, Kyvik, KO, Kaprio, J, Price, JF, Dedoussis, GV, Deloukas, P, Meneton, P, Lind, L, Boehnke, M, Shuldiner, AR, van Duijn, CM, Morris, AD, Toenjes, A, Peyser, PA, Beilby, JP, Korner, A, Kuusisto, J, Langenberg, C, Ingelsson, E, Laakso, M, Bornstein, SR, Schwarz, PEH, Lakka, TA, Rauramaa, R, Adair, LS, Smith, GD, Spector, TD, Illig, T, de Faire, U, Hamsten, A, Gudnason, V, Kivimaki, M, Hingorani, A, Keinanen-Kiukaanniemi, SM, Saaristo, TE, Boomsma, DI, van der Harst, P, Dupuis, J, Bakker, SJL, Kong, A, Gigante, B, Kumari, M, Herder, C, Munroe, PB, Caulfield, M, Jula, A, Mangino, M, Prokopenko, I & Barroso, I 2012, 'Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways' Nature Genetics, vol 44, no. 9, pp. 991-1005.

APA

Scott, R. A., Lagou, V., Welch, R. P., Wheeler, E., Montasser, M. E., Luan, J., MäGi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., Kanoni, S., Rasmussen-Torvik, L. J., Yengo, L., Lecoeur, C., Shungin, D., Sanna, S., Sidore, C., Johnson, P. C. D., Jukema, J. W., Johnson, T., Mahajan, A., Verweij, N., Thorleifsson, G., Hottenga, J. J., Shah, S., Smith, A. V., Sennblad, B., Gieger, C., Salo, P., Perola, M., Timpson, N. J., Evans, D. M., St Pourcain, B., Wu, Y., Andrews, J. S., Hui, J., Bielak, L. F., Zhao, W., Horikoshi, M., Navarro, P., Isaacs, A., O'Connell, J. R., Stirrups, K., Vitart, V., Hayward, C., Esko, T., Mihailov, E., Fraser, R. M., Fall, T., Voight, B. F., Raychaudhuri, S., Chen, H., Lindgren, C. M., Morris, A. P., Rayner, N. W., Robertson, N., Rybin, D., Liu, C-T., Beckmann, J. S., Willems, S. M., Chines, P. S., Jackson, A. U., Kang, H. M., Stringham, H. M., Song, K., Tanaka, T., Peden, J. F., Goel, A., Hicks, A. A., An, P., Muller-Nurasyid, M., Franco-Cereceda, A., Folkersen, L., Marullo, L., Jansen, H., Oldehinkel, A. J., Bruinenberg, M., Pankow, J. S., North, K. E., Forouhi, N. G., Loos, R. J. F., Edkins, S., Varga, T. V., Hallmans, G., Oksa, H., Mulas, A., Nagaraja, R., Trompet, S., Ford, I., Small, K., Miljkovic, I., Liu, Y., Atalay, M., Kiess, W., James, A. L., Rivadeneira, F., Uitterlinden, A. G., Palmer, C. N. A., Doney, A. S. F., Willemsen, G., Smit, J. H., Campbell, S., Polasek, O., Bonnycastle, L. L., Hercberg, S., Dimitriou, M., Bolton, J. L., Fowkes, G. R., Kovacs, P., Lindström, J., Zemunik, T., Bandinelli, S., Wild, S. H., Basart, H. V., Rathmann, W., Grallert, H., Maerz, W., Kleber, M. E., Boehm, B. O., Peters, A., Pramstaller, P. P., Province, M. A., Borecki, I. B., Hastie, N. D., Rudan, I., Campbell, H., Watkins, H., Farrall, M., Stumvoll, M., Ferrucci, L., Waterworth, D. M., Bergman, R. N., Collins, F. S., Watanabe, R. M., Pedersen, N. L., Sattar, N., Harris, T. B., Cucca, F., Ripatti, S., Salomaa, V., Mohlke, K. L., Balkau, B., Froguel, P., Pouta, A., Jarvelin, M-R., Wareham, N. J., Bouatia-Naji, N., McCarthy, M. I., Franks, P. W., Meigs, J. B., Teslovich, T. M., Florez, J. C., Tuomilehto, J., de Geus, E. J. C., Penninx, B. W., Hofman, A., Oostra, B. A., Psaty, B. M., Vollenweider, P., Wilson, J. F., Hovingh, G. K., Wright, A. F., Metspalu, A., Uusitupa, M., Magnusson, P. K. E., Kyvik, K. O., Kaprio, J., Price, J. F., Dedoussis, G. V., Deloukas, P., Meneton, P., Lind, L., Boehnke, M., Shuldiner, A. R., van Duijn, C. M., Morris, A. D., Toenjes, A., Peyser, P. A., Beilby, J. P., Korner, A., Kuusisto, J., Langenberg, C., Ingelsson, E., Laakso, M., Bornstein, S. R., Schwarz, P. E. H., Lakka, T. A., Rauramaa, R., Adair, L. S., Smith, G. D., Spector, T. D., Illig, T., de Faire, U., Hamsten, A., Gudnason, V., Kivimaki, M., Hingorani, A., Keinanen-Kiukaanniemi, S. M., Saaristo, T. E., Boomsma, D. I., van der Harst, P., Dupuis, J., Bakker, S. J. L., Kong, A., Gigante, B., Kumari, M., Herder, C., Munroe, P. B., Caulfield, M., Jula, A., Mangino, M., Prokopenko, I., & Barroso, I. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44(9), 991-1005, doi: 10.1038/ng.2385

Vancouver

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics. 2012;44(9):991-1005.

Author

Scott, Robert A.; Lagou, Vasiliki; Welch, Ryan P.; Wheeler, Eleanor; Montasser, May E.; Luan, Jian'an; MäGi, Reedik; Strawbridge, Rona J.; Rehnberg, Emil; Gustafsson, Sefan; Kanoni, Stavroula; Rasmussen-Torvik, Laura J.; Yengo, Loic; Lecoeur, Cecile; Shungin, Dmitry; Sanna, Serena; Sidore, Carlo; Johnson, Paul C.D.; Jukema, J.Wouter; Johnson, Toby; Mahajan, Anubha; Verweij, Niek; Thorleifsson, Gudmar; Hottenga, Jouke Jan; Shah, Sonia; Smith, Albert V.; Sennblad, Bengt; Gieger, Christian; Salo, Perttu; Perola, Markus; Timpson, Nicholas J.; Evans, David M.; St Pourcain, Beate; Wu, Ying; Andrews, Jeanette S.; Hui, Jennie; Bielak, Lawrence F.; Zhao, Wei; Horikoshi, Momoko; Navarro, Pau; Isaacs, Aaron; O'Connell, Jeffrey R.; Stirrups, Kathleen; Vitart, Veronique; Hayward, Caroline; Esko, Tonu; Mihailov, Evelin; Fraser, Ross M.; Fall, Tove; Voight, Benjamin F.; Raychaudhuri, Soumya; Chen, Han; Lindgren, Cecilia M.; Morris, Andrew P.; Rayner, Nigel W.; Robertson, Neil; Rybin, Denis; Liu, Ching-Ti; Beckmann, Jacques S.; Willems, Sara M.; Chines, Peter S.; Jackson, Anne U.; Kang, Hyun Min; Stringham, Heather M.; Song, Kijoung; Tanaka, Toshiko; Peden, John F.; Goel, Anuj; Hicks, Andrew A.; An, Ping; Muller-Nurasyid, Martina; Franco-Cereceda, Anders; Folkersen, Lasse; Marullo, Letizia; Jansen, Hanneke; Oldehinkel, Albertine J.; Bruinenberg, Marcel; Pankow, James S.; North, Kari E.; Forouhi, Nita G.; Loos, Ruth J. F.; Edkins, Sarah; Varga, Tibor V.; Hallmans, Goran; Oksa, Heikki; Mulas, Antonella; Nagaraja, Ramaiah; Trompet, Stella; Ford, Ian; Small, Kerrin; Miljkovic, Iva; Liu, Yongmei; Atalay, Mustafa; Kiess, Wieland; James, Alan L. ; Rivadeneira, Fernando; Uitterlinden, Andre G.; Palmer, Colin N A; Doney, Alex S. F.; Willemsen, Gonneke; Smit, Johannes H.; Campbell, Susan; Polasek, Ozren; Bonnycastle, Lori L.; Hercberg, Serge; Dimitriou, Maria; Bolton, Jennifer L. ; Fowkes, Gerard R. ; Kovacs, Peter; Lindström, Jaana; Zemunik, Tatijana; Bandinelli, Stefania; Wild, Sarah H.; Basart, Hanneke V.; Rathmann, Wolfgang; Grallert, Harald; Maerz, Winfried; Kleber, Marcus E.; Boehm, Bernhard O.; Peters, Annette; Pramstaller, Peter P; Province, Michael A.; Borecki, Ingrid B.; Hastie, Nicholas D.; Rudan, Igor; Campbell, Harry; Watkins, Hugh; Farrall, Martin; Stumvoll, Michael; Ferrucci, Luigi; Waterworth, Dawn M.; Bergman, Richard N.; Collins, Francis S.; Watanabe, Richard M; Pedersen, Nancy L.; Sattar, Naveed; Harris, Tamara B.; Cucca, Francesco; Ripatti, Samuli; Salomaa, Veikko; Mohlke, Karen L.; Balkau, Beverley; Froguel, Philippe; Pouta, Anneli; Jarvelin, Marjo-Riitta; Wareham, Nicholas J.; Bouatia-Naji, Nabila; McCarthy, Mark I.; Franks, Paul W.; Meigs, James B.; Teslovich, Tanya M.; Florez, Jose C.; Tuomilehto, Jaakko; de Geus, Eco J C ; Penninx, Brenda W ; Hofman, Albert; Oostra, Ben A ; Psaty, Bruce M; Vollenweider, Peter; Wilson, James F ; Hovingh, G Kees; Wright, Alan F ; Metspalu, Andres; Uusitupa, Matti; Magnusson, Patrik K E ; Kyvik, Kirsten O ; Kaprio, Jaakko; Price, Jackie F ; Dedoussis, George V; Deloukas, Panos; Meneton, Pierre; Lind, Lars; Boehnke, Michael; Shuldiner, Alan R; van Duijn, Cornelia M ; Morris, Andrew D.; Toenjes, Anke; Peyser, Patricia A.; Beilby, John P.; Korner, Antje; Kuusisto, Johanna; Langenberg, Claudia; Ingelsson, Erik; Laakso, Markku; Bornstein, Stefan R.; Schwarz, Peter E. H.; Lakka, Timo A.; Rauramaa, Rainer; Adair, Linda S.; Smith, George Davey; Spector, Tim D.; Illig, Thomas; de Faire, Ulf; Hamsten, Anders; Gudnason, Vilmundur; Kivimaki, Mika; Hingorani, Aroon; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Boomsma, Dorret I.; van der Harst, Pim; Dupuis, Josee; Bakker, Stephan J. L.; Kong, Augustine; Gigante, Bruna; Kumari, Meena; Herder, Christian; Munroe, Patricia B.; Caulfield, Mark; Jula, Antti; Mangino, Massimo; Prokopenko, Inga; Barroso, Ines / Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

In: Nature Genetics, Vol. 44, No. 9, 2012, p. 991-1005.

Research output: Contribution to journal › Article

Bibtex - Download

@article{c3f0df5bd8974be59da83663dd10a052,
title = "Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways",
author = "Scott, {Robert A.} and Vasiliki Lagou and Welch, {Ryan P.} and Eleanor Wheeler and Montasser, {May E.} and Jian'an Luan and Reedik MäGi and Strawbridge, {Rona J.} and Emil Rehnberg and Sefan Gustafsson and Stavroula Kanoni and Rasmussen-Torvik, {Laura J.} and Loic Yengo and Cecile Lecoeur and Dmitry Shungin and Serena Sanna and Carlo Sidore and Johnson, {Paul C.D.} and J.Wouter Jukema and Toby Johnson and Anubha Mahajan and Niek Verweij and Gudmar Thorleifsson and Hottenga, {Jouke Jan} and Sonia Shah and Smith, {Albert V.} and Bengt Sennblad and Christian Gieger and Perttu Salo and Markus Perola and Timpson, {Nicholas J.} and Evans, {David M.} and {St Pourcain}, Beate and Ying Wu and Andrews, {Jeanette S.} and Jennie Hui and Bielak, {Lawrence F.} and Wei Zhao and Momoko Horikoshi and Pau Navarro and Aaron Isaacs and O'Connell, {Jeffrey R.} and Kathleen Stirrups and Veronique Vitart and Caroline Hayward and Tonu Esko and Evelin Mihailov and Fraser, {Ross M.} and Tove Fall and Voight, {Benjamin F.} and Soumya Raychaudhuri and Han Chen and Lindgren, {Cecilia M.} and Morris, {Andrew P.} and Rayner, {Nigel W.} and Neil Robertson and Denis Rybin and Ching-Ti Liu and Beckmann, {Jacques S.} and Willems, {Sara M.} and Chines, {Peter S.} and Jackson, {Anne U.} and Kang, {Hyun Min} and Stringham, {Heather M.} and Kijoung Song and Toshiko Tanaka and Peden, {John F.} and Anuj Goel and Hicks, {Andrew A.} and Ping An and Martina Muller-Nurasyid and Anders Franco-Cereceda and Lasse Folkersen and Letizia Marullo and Hanneke Jansen and Oldehinkel, {Albertine J.} and Marcel Bruinenberg and Pankow, {James S.} and North, {Kari E.} and Forouhi, {Nita G.} and Loos, {Ruth J. F.} and Sarah Edkins and Varga, {Tibor V.} and Goran Hallmans and Heikki Oksa and Antonella Mulas and Ramaiah Nagaraja and Stella Trompet and Ian Ford and Kerrin Small and Iva Miljkovic and Yongmei Liu and Mustafa Atalay and Wieland Kiess and James, {Alan L.} and Fernando Rivadeneira and Uitterlinden, {Andre G.} and Palmer, {Colin N A} and Doney, {Alex S. F.} and Gonneke Willemsen and Smit, {Johannes H.} and Susan Campbell and Ozren Polasek and Bonnycastle, {Lori L.} and Serge Hercberg and Maria Dimitriou and Bolton, {Jennifer L.} and Fowkes, {Gerard R.} and Peter Kovacs and Jaana Lindström and Tatijana Zemunik and Stefania Bandinelli and Wild, {Sarah H.} and Basart, {Hanneke V.} and Wolfgang Rathmann and Harald Grallert and Winfried Maerz and Kleber, {Marcus E.} and Boehm, {Bernhard O.} and Annette Peters and Pramstaller, {Peter P} and Province, {Michael A.} and Borecki, {Ingrid B.} and Hastie, {Nicholas D.} and Igor Rudan and Harry Campbell and Hugh Watkins and Martin Farrall and Michael Stumvoll and Luigi Ferrucci and Waterworth, {Dawn M.} and Bergman, {Richard N.} and Collins, {Francis S.} and Watanabe, {Richard M} and Pedersen, {Nancy L.} and Naveed Sattar and Harris, {Tamara B.} and Francesco Cucca and Samuli Ripatti and Veikko Salomaa and Mohlke, {Karen L.} and Beverley Balkau and Philippe Froguel and Anneli Pouta and Marjo-Riitta Jarvelin and Wareham, {Nicholas J.} and Nabila Bouatia-Naji and McCarthy, {Mark I.} and Franks, {Paul W.} and Meigs, {James B.} and Teslovich, {Tanya M.} and Florez, {Jose C.} and Jaakko Tuomilehto and {de Geus}, {Eco J C} and Penninx, {Brenda W} and Albert Hofman and Oostra, {Ben A} and Psaty, {Bruce M} and Peter Vollenweider and Wilson, {James F} and Hovingh, {G Kees} and Wright, {Alan F} and Andres Metspalu and Matti Uusitupa and Magnusson, {Patrik K E} and Kyvik, {Kirsten O} and Jaakko Kaprio and Price, {Jackie F} and Dedoussis, {George V} and Panos Deloukas and Pierre Meneton and Lars Lind and Michael Boehnke and Shuldiner, {Alan R} and {van Duijn}, {Cornelia M} and Morris, {Andrew D.} and Anke Toenjes and Peyser, {Patricia A.} and Beilby, {John P.} and Antje Korner and Johanna Kuusisto and Claudia Langenberg and Erik Ingelsson and Markku Laakso and Bornstein, {Stefan R.} and Schwarz, {Peter E. H.} and Lakka, {Timo A.} and Rainer Rauramaa and Adair, {Linda S.} and Smith, {George Davey} and Spector, {Tim D.} and Thomas Illig and {de Faire}, Ulf and Anders Hamsten and Vilmundur Gudnason and Mika Kivimaki and Aroon Hingorani and Keinanen-Kiukaanniemi, {Sirkka M.} and Saaristo, {Timo E.} and Boomsma, {Dorret I.} and {van der Harst}, Pim and Josee Dupuis and Bakker, {Stephan J. L.} and Augustine Kong and Bruna Gigante and Meena Kumari and Christian Herder and Munroe, {Patricia B.} and Mark Caulfield and Antti Jula and Massimo Mangino and Inga Prokopenko and Ines Barroso",
year = "2012",
volume = "44",
number = "9",
pages = "991--1005",
journal = "Nature Genetics",
issn = "1061-4036",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

A1 - Scott,Robert A.

A1 - Lagou,Vasiliki

A1 - Welch,Ryan P.

A1 - Wheeler,Eleanor

A1 - Montasser,May E.

A1 - Luan,Jian'an

A1 - MäGi,Reedik

A1 - Strawbridge,Rona J.

A1 - Rehnberg,Emil

A1 - Gustafsson,Sefan

A1 - Kanoni,Stavroula

A1 - Rasmussen-Torvik,Laura J.

A1 - Yengo,Loic

A1 - Lecoeur,Cecile

A1 - Shungin,Dmitry

A1 - Sanna,Serena

A1 - Sidore,Carlo

A1 - Johnson,Paul C.D.

A1 - Jukema,J.Wouter

A1 - Johnson,Toby

A1 - Mahajan,Anubha

A1 - Verweij,Niek

A1 - Thorleifsson,Gudmar

A1 - Hottenga,Jouke Jan

A1 - Shah,Sonia

A1 - Smith,Albert V.

A1 - Sennblad,Bengt

A1 - Gieger,Christian

A1 - Salo,Perttu

A1 - Perola,Markus

A1 - Timpson,Nicholas J.

A1 - Evans,David M.

A1 - St Pourcain,Beate

A1 - Wu,Ying

A1 - Andrews,Jeanette S.

A1 - Hui,Jennie

A1 - Bielak,Lawrence F.

A1 - Zhao,Wei

A1 - Horikoshi,Momoko

A1 - Navarro,Pau

A1 - Isaacs,Aaron

A1 - O'Connell,Jeffrey R.

A1 - Stirrups,Kathleen

A1 - Vitart,Veronique

A1 - Hayward,Caroline

A1 - Esko,Tonu

A1 - Mihailov,Evelin

A1 - Fraser,Ross M.

A1 - Fall,Tove

A1 - Voight,Benjamin F.

A1 - Raychaudhuri,Soumya

A1 - Chen,Han

A1 - Lindgren,Cecilia M.

A1 - Morris,Andrew P.

A1 - Rayner,Nigel W.

A1 - Robertson,Neil

A1 - Rybin,Denis

A1 - Liu,Ching-Ti

A1 - Beckmann,Jacques S.

A1 - Willems,Sara M.

A1 - Chines,Peter S.

A1 - Jackson,Anne U.

A1 - Kang,Hyun Min

A1 - Stringham,Heather M.

A1 - Song,Kijoung

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AU - Magnusson,Patrik K E

AU - Kyvik,Kirsten O

AU - Kaprio,Jaakko

AU - Price,Jackie F

AU - Dedoussis,George V

AU - Deloukas,Panos

AU - Meneton,Pierre

AU - Lind,Lars

AU - Boehnke,Michael

AU - Shuldiner,Alan R

AU - van Duijn,Cornelia M

AU - Morris,Andrew D.

AU - Toenjes,Anke

AU - Peyser,Patricia A.

AU - Beilby,John P.

AU - Korner,Antje

AU - Kuusisto,Johanna

AU - Langenberg,Claudia

AU - Ingelsson,Erik

AU - Laakso,Markku

AU - Bornstein,Stefan R.

AU - Schwarz,Peter E. H.

AU - Lakka,Timo A.

AU - Rauramaa,Rainer

AU - Adair,Linda S.

AU - Smith,George Davey

AU - Spector,Tim D.

AU - Illig,Thomas

AU - de Faire,Ulf

AU - Hamsten,Anders

AU - Gudnason,Vilmundur

AU - Kivimaki,Mika

AU - Hingorani,Aroon

AU - Keinanen-Kiukaanniemi,Sirkka M.

AU - Saaristo,Timo E.

AU - Boomsma,Dorret I.

AU - van der Harst,Pim

AU - Dupuis,Josee

AU - Bakker,Stephan J. L.

AU - Kong,Augustine

AU - Gigante,Bruna

AU - Kumari,Meena

AU - Herder,Christian

AU - Munroe,Patricia B.

AU - Caulfield,Mark

AU - Jula,Antti

AU - Mangino,Massimo

AU - Prokopenko,Inga

AU - Barroso,Ines

PY - 2012

Y1 - 2012

N2 - Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q <0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control. © 2012 Nature America, Inc. All rights reserved.

AB - Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q <0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control. © 2012 Nature America, Inc. All rights reserved.

U2 - 10.1038/ng.2385

DO - 10.1038/ng.2385

M1 - Article

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

VL - 44

SP - 991

EP - 1005

ER -

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    Research output: Contribution to journal › Article

  • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

    Morris, A. P. , Voight, B. F. , Teslovich, T. M. , Ferreira, T. , Segre, A. V. , Steinthorsdottir, V. , Strawbridge, R. J. , Khan, H. , Grallert, H. , Mahajan, A. , Prokopenko, I. , Kang, H. M. , Dina, C. , Esko, T. , Fraser, R. M. , Kanoni, S. , Kumar, A. , Lagou, V. , Langenberg, C. , Luan, J. & 185 others Lindgren, C. M., Mueller-Nurasyid, M., Pechlivanis, S., Rayner, N. W., Scott, L. J., Wiltshire, S., Yengo, L., Kinnunen, L., Rossin, E. J., Raychaudhuri, S., Johnson, A. D., Dimas, A. S., Loos, R. J. F., Vedantam, S., Chen, H., Florez, J. C., Fox, C., Liu, C-T., Rybin, D., Couper, D. J., Kao, W. H. L., Li, M., Cornelis, M. C., Kraft, P., Sun, Q., van Dam, R. M., Stringham, H. M., Chines, P. S., Fischer, K., Fontanillas, P., Holmen, O. L., Hunt, S. E., Jackson, A. U., Kong, A., Lawrence, R., Meyer, J., Perry, J. R. B., Platou, C. G. P., Potter, S., Rehnberg, E., Robertson, N., Sivapalaratnam, S., Stancakova, A., Stirrups, K., Thorleifsson, G., Tikkanen, E., Wood, A. R., Almgren, P., Atalay, M., Benediktsson, R., Bonnycastle, L. L., Burtt, N., Carey, J., Charpentier, G., Crenshaw, A. T., Doney, A. S. F., Dorkhan, M., Edkins, S., Emilsson, V., Eury, E., Forsen, T., Gertow, K., Gigante, B., Grant, G. B., Groves, C. J., Guiducci, C., Herder, C., Hreidarsson, A. B., Hui, J., James, A., Jonsson, A., Rathmann, W., Klopp, N., Kravic, J., Krjutskov, K., Langford, C., Leander, K., Lindholm, E., Lobbens, S., Mannisto, S., Mirza, G., Muehleisen, T. W., Musk, B., Parkin, M., Rallidis, L., Saramies, J., Sennblad, B., Shah, S., Sigurdsson, G., Silveira, A., Steinbach, G., Thorand, B., Trakalo, J., Veglia, F., Wennauer, R., Winckler, W., Zabaneh, D., Campbell, H., van Duijn, C., Uitterlinden, A. G., Hofman, A., Sijbrands, E., Abecasis, G. R., Owen, K. R., Zeggini, E., Trip, M. D., Forouhi, N. G., Syvanen, A-C., Eriksson, J. G., Peltonen, L., Noethen, M. M., Balkau, B., Palmer, C. N. A., Lyssenko, V., Tuomi, T., Isomaa, B., Hunter, D. J., Qi, L., Shuldiner, A. R., Roden, M., Barroso, I., Wilsgaard, T., Beilby, J., Hovingh, K., Price, J. F., Wilson, J. F., Rauramaa, R., Lakka, T. A., Lind, L., Dedoussis, G., Njolstad, I., Pedersen, N. L., Khaw, K-T., Wareham, N. J., Keinanen-Kiukaanniemi, S. M., Saaristo, T. E., Korpi-Hyovalti, E., Saltevo, J., Laakso, M., Kuusisto, J., Metspalu, A., Collins, F. S., Mohlke, K. L., Bergman, R. N., Tuomilehto, J., Boehm, B. O., Gieger, C., Hveem, K., Cauchi, S., Froguel, P., Baldassarre, D., Tremoli, E., Humphries, S. E., Saleheen, D., Danesh, J., Ingelsson, E., Ripatti, S., Salomaa, V., Erbel, R., Joeckel, K-H., Moebus, S., Peters, A., Illig, T., de Faire, U., Hamsten, A., Morris, A. D., Donnelly, P. J., Frayling, T. M., Hattersley, A. T., Boerwinkle, E., Melander, O., Kathiresan, S., Nilsson, P. M., Deloukas, P., Thorsteinsdottir, U., Groop, L. C., Stefansson, K., Hu, F., Pankow, J. S., Dupuis, J., Meigs, J. B., Altshuler, D., Boehnke, M., McCarthy, M. I. & DIAbet Genetics Replication, Asian Genetic Epidemiology, Genetic Invest ANthropometric, Meta-Anal Glucose Insulin-Related, S Asian Type 2 Diabet SAT2D, Wellcome Trust Case Control Sep-2012 In : Nature Genetics. 44, 9, p. 981-990, 12 p.

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