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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. / Morris, Andrew P.; Voight, Benjamin F.; Teslovich, Tanya M.; Ferreira, Teresa; Segre, Ayellet V.; Steinthorsdottir, Valgerdur; Strawbridge, Rona J.; Khan, Hassan; Grallert, Harald; Mahajan, Anubha; Prokopenko, Inga; Kang, Hyun Min; Dina, Christian; Esko, Tonu; Fraser, Ross M.; Kanoni, Stavroula; Kumar, Ashish; Lagou, Vasiliki; Langenberg, Claudia; Luan, Jian'an; Lindgren, Cecilia M.; Mueller-Nurasyid, Martina; Pechlivanis, Sonali; Rayner, N. William; Scott, Laura J.; Wiltshire, Steven; Yengo, Loic; Kinnunen, Leena; Rossin, Elizabeth J.; Raychaudhuri, Soumya; Johnson, Andrew D.; Dimas, Antigone S.; Loos, Ruth J. F.; Vedantam, Sailaja; Chen, Han; Florez, Jose C.; Fox, Caroline; Liu, Ching-Ti; Rybin, Denis; Couper, David J.; Kao, Wen Hong L.; Li, Man; Cornelis, Marilyn C.; Kraft, Peter; Sun, Qi; van Dam, Rob M.; Stringham, Heather M.; Chines, Peter S.; Fischer, Krista; Fontanillas, Pierre; Holmen, Oddgeir L.; Hunt, Sarah E.; Jackson, Anne U.; Kong, Augustine; Lawrence, Robert; Meyer, Julia; Perry, John R. B.; Platou, Carl G. P.; Potter, Simon; Rehnberg, Emil; Robertson, Neil; Sivapalaratnam, Suthesh; Stancakova, Alena; Stirrups, Kathleen; Thorleifsson, Gudmar; Tikkanen, Emmi; Wood, Andrew R.; Almgren, Peter; Atalay, Mustafa; Benediktsson, Rafn; Bonnycastle, Lori L.; Burtt, Noel; Carey, Jason; Charpentier, Guillaume; Crenshaw, Andrew T.; Doney, Alex S. F.; Dorkhan, Mozhgan; Edkins, Sarah; Emilsson, Valur; Eury, Elodie; Forsen, Tom; Gertow, Karl; Gigante, Bruna; Grant, George B.; Groves, Christopher J.; Guiducci, Candace; Herder, Christian; Hreidarsson, Astradur B.; Hui, Jennie; James, Alan; Jonsson, Anna; Rathmann, Wolfgang; Klopp, Norman; Kravic, Jasmina; Krjutskov, Kaarel; Langford, Cordelia; Leander, Karin; Lindholm, Eero; Lobbens, Stephane; Mannisto, Satu; Mirza, Ghazala; Mühleisen, Thomas W.; Musk, Bill; Parkin, Melissa; Rallidis, Loukianos; Saramies, Jouko; Sennblad, Bengt; Shah, Sonia; Sigurdsson, Gunnar; Silveira, Angela; Steinbach, Gerald; Thorand, Barbara; Trakalo, Joseph; Veglia, Fabrizio; Wennauer, Roman; Winckler, Wendy; Zabaneh, Delilah; Campbell, Harry; van Duijn, Cornelia; Uitterlinden, Andre G.; Hofman, Albert; Sijbrands, Eric; Abecasis, Goncalo R.; Owen, Katharine R.; Zeggini, Eleftheria; Trip, Mieke D.; Forouhi, Nita G.; Syvanen, Ann-Christine; Eriksson, Johan G.; Peltonen, Leena; Noethen, Markus M.; Balkau, Beverley; Palmer, Colin N. A.; Lyssenko, Valeriya; Tuomi, Tiinamaija; Isomaa, Bo; Hunter, David J.; Qi, Lu; Shuldiner, Alan R.; Roden, Michael; Barroso, Ines; Wilsgaard, Tom; Beilby, John; Hovingh, Kees; Price, Jackie F.; Wilson, James F.; Rauramaa, Rainer; Lakka, Timo A.; Lind, Lars; Dedoussis, George; Njolstad, Inger; Pedersen, Nancy L.; Khaw, Kay-Tee; Wareham, Nicholas J.; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Korpi-Hyovalti, Eeva; Saltevo, Juha; Laakso, Markku; Kuusisto, Johanna; Metspalu, Andres; Collins, Francis S.; Mohlke, Karen L.; Bergman, Richard N.; Tuomilehto, Jaakko; Boehm, Bernhard O.; Gieger, Christian; Hveem, Kristian; Cauchi, Stephane; Froguel, Philippe; Baldassarre, Damiano; Tremoli, Elena; Humphries, Steve E.; Saleheen, Danish; Danesh, John; Ingelsson, Erik; Ripatti, Samuli; Salomaa, Veikko; Erbel, Raimund; Jöckel, Karl-Heinz; Moebus, Susanne; Peters, Annette; Illig, Thomas; de Faire, Ulf; Hamsten, Anders; Morris, Andrew D.; Donnelly, Peter J.; Frayling, Timothy M.; Hattersley, Andrew T.; Boerwinkle, Eric; Melander, Olle; Kathiresan, Sekar; Nilsson, Peter M.; Deloukas, Panos; Thorsteinsdottir, Unnur; Groop, Leif C.; Stefansson, Kari; Hu, Frank; Pankow, James S.; Dupuis, Josee; Meigs, James B.; Altshuler, David; Boehnke, Michael; McCarthy, Mark I.; DIAbet Genetics Replication, Asian Genetic Epidemiology, Genetic Invest ANthropometric, Meta-Anal Glucose Insulin-Related, S Asian Type 2 Diabet SAT2D, Wellcome Trust Case Control.

In: Nature Genetics, Vol. 44, No. 9, 09.2012, p. 981-990.

Research output: Contribution to journalArticle

Harvard

Morris, AP, Voight, BF, Teslovich, TM, Ferreira, T, Segre, AV, Steinthorsdottir, V, Strawbridge, RJ, Khan, H, Grallert, H, Mahajan, A, Prokopenko, I, Kang, HM, Dina, C, Esko, T, Fraser, RM, Kanoni, S, Kumar, A, Lagou, V, Langenberg, C, Luan, J, Lindgren, CM, Mueller-Nurasyid, M, Pechlivanis, S, Rayner, NW, Scott, LJ, Wiltshire, S, Yengo, L, Kinnunen, L, Rossin, EJ, Raychaudhuri, S, Johnson, AD, Dimas, AS, Loos, RJF, Vedantam, S, Chen, H, Florez, JC, Fox, C, Liu, C-T, Rybin, D, Couper, DJ, Kao, WHL, Li, M, Cornelis, MC, Kraft, P, Sun, Q, van Dam, RM, Stringham, HM, Chines, PS, Fischer, K, Fontanillas, P, Holmen, OL, Hunt, SE, Jackson, AU, Kong, A, Lawrence, R, Meyer, J, Perry, JRB, Platou, CGP, Potter, S, Rehnberg, E, Robertson, N, Sivapalaratnam, S, Stancakova, A, Stirrups, K, Thorleifsson, G, Tikkanen, E, Wood, AR, Almgren, P, Atalay, M, Benediktsson, R, Bonnycastle, LL, Burtt, N, Carey, J, Charpentier, G, Crenshaw, AT, Doney, ASF, Dorkhan, M, Edkins, S, Emilsson, V, Eury, E, Forsen, T, Gertow, K, Gigante, B, Grant, GB, Groves, CJ, Guiducci, C, Herder, C, Hreidarsson, AB, Hui, J, James, A, Jonsson, A, Rathmann, W, Klopp, N, Kravic, J, Krjutskov, K, Langford, C, Leander, K, Lindholm, E, Lobbens, S, Mannisto, S, Mirza, G, Mühleisen, TW, Musk, B, Parkin, M, Rallidis, L, Saramies, J, Sennblad, B, Shah, S, Sigurdsson, G, Silveira, A, Steinbach, G, Thorand, B, Trakalo, J, Veglia, F, Wennauer, R, Winckler, W, Zabaneh, D, Campbell, H, van Duijn, C, Uitterlinden, AG, Hofman, A, Sijbrands, E, Abecasis, GR, Owen, KR, Zeggini, E, Trip, MD, Forouhi, NG, Syvanen, A-C, Eriksson, JG, Peltonen, L, Noethen, MM, Balkau, B, Palmer, CNA, Lyssenko, V, Tuomi, T, Isomaa, B, Hunter, DJ, Qi, L, Shuldiner, AR, Roden, M, Barroso, I, Wilsgaard, T, Beilby, J, Hovingh, K, Price, JF, Wilson, JF, Rauramaa, R, Lakka, TA, Lind, L, Dedoussis, G, Njolstad, I, Pedersen, NL, Khaw, K-T, Wareham, NJ, Keinanen-Kiukaanniemi, SM, Saaristo, TE, Korpi-Hyovalti, E, Saltevo, J, Laakso, M, Kuusisto, J, Metspalu, A, Collins, FS, Mohlke, KL, Bergman, RN, Tuomilehto, J, Boehm, BO, Gieger, C, Hveem, K, Cauchi, S, Froguel, P, Baldassarre, D, Tremoli, E, Humphries, SE, Saleheen, D, Danesh, J, Ingelsson, E, Ripatti, S, Salomaa, V, Erbel, R, Jöckel, K-H, Moebus, S, Peters, A, Illig, T, de Faire, U, Hamsten, A, Morris, AD, Donnelly, PJ, Frayling, TM, Hattersley, AT, Boerwinkle, E, Melander, O, Kathiresan, S, Nilsson, PM, Deloukas, P, Thorsteinsdottir, U, Groop, LC, Stefansson, K, Hu, F, Pankow, JS, Dupuis, J, Meigs, JB, Altshuler, D, Boehnke, M, McCarthy, MI & DIAbet Genetics Replication, Asian Genetic Epidemiology, Genetic Invest ANthropometric, Meta-Anal Glucose Insulin-Related, S Asian Type 2 Diabet SAT2D, Wellcome Trust Case Control 2012, 'Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes' Nature Genetics, vol 44, no. 9, pp. 981-990.

APA

Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segre, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., Mahajan, A., Prokopenko, I., Kang, H. M., Dina, C., Esko, T., Fraser, R. M., Kanoni, S., Kumar, A., Lagou, V., Langenberg, C., Luan, J., Lindgren, C. M., Mueller-Nurasyid, M., Pechlivanis, S., Rayner, N. W., Scott, L. J., Wiltshire, S., Yengo, L., Kinnunen, L., Rossin, E. J., Raychaudhuri, S., Johnson, A. D., Dimas, A. S., Loos, R. J. F., Vedantam, S., Chen, H., Florez, J. C., Fox, C., Liu, C-T., Rybin, D., Couper, D. J., Kao, W. H. L., Li, M., Cornelis, M. C., Kraft, P., Sun, Q., van Dam, R. M., Stringham, H. M., Chines, P. S., Fischer, K., Fontanillas, P., Holmen, O. L., Hunt, S. E., Jackson, A. U., Kong, A., Lawrence, R., Meyer, J., Perry, J. R. B., Platou, C. G. P., Potter, S., Rehnberg, E., Robertson, N., Sivapalaratnam, S., Stancakova, A., Stirrups, K., Thorleifsson, G., Tikkanen, E., Wood, A. R., Almgren, P., Atalay, M., Benediktsson, R., Bonnycastle, L. L., Burtt, N., Carey, J., Charpentier, G., Crenshaw, A. T., Doney, A. S. F., Dorkhan, M., Edkins, S., Emilsson, V., Eury, E., Forsen, T., Gertow, K., Gigante, B., Grant, G. B., Groves, C. J., Guiducci, C., Herder, C., Hreidarsson, A. B., Hui, J., James, A., Jonsson, A., Rathmann, W., Klopp, N., Kravic, J., Krjutskov, K., Langford, C., Leander, K., Lindholm, E., Lobbens, S., Mannisto, S., Mirza, G., Mühleisen, T. W., Musk, B., Parkin, M., Rallidis, L., Saramies, J., Sennblad, B., Shah, S., Sigurdsson, G., Silveira, A., Steinbach, G., Thorand, B., Trakalo, J., Veglia, F., Wennauer, R., Winckler, W., Zabaneh, D., Campbell, H., van Duijn, C., Uitterlinden, A. G., Hofman, A., Sijbrands, E., Abecasis, G. R., Owen, K. R., Zeggini, E., Trip, M. D., Forouhi, N. G., Syvanen, A-C., Eriksson, J. G., Peltonen, L., Noethen, M. M., Balkau, B., Palmer, C. N. A., Lyssenko, V., Tuomi, T., Isomaa, B., Hunter, D. J., Qi, L., Shuldiner, A. R., Roden, M., Barroso, I., Wilsgaard, T., Beilby, J., Hovingh, K., Price, J. F., Wilson, J. F., Rauramaa, R., Lakka, T. A., Lind, L., Dedoussis, G., Njolstad, I., Pedersen, N. L., Khaw, K-T., Wareham, N. J., Keinanen-Kiukaanniemi, S. M., Saaristo, T. E., Korpi-Hyovalti, E., Saltevo, J., Laakso, M., Kuusisto, J., Metspalu, A., Collins, F. S., Mohlke, K. L., Bergman, R. N., Tuomilehto, J., Boehm, B. O., Gieger, C., Hveem, K., Cauchi, S., Froguel, P., Baldassarre, D., Tremoli, E., Humphries, S. E., Saleheen, D., Danesh, J., Ingelsson, E., Ripatti, S., Salomaa, V., Erbel, R., Jöckel, K-H., Moebus, S., Peters, A., Illig, T., de Faire, U., Hamsten, A., Morris, A. D., Donnelly, P. J., Frayling, T. M., Hattersley, A. T., Boerwinkle, E., Melander, O., Kathiresan, S., Nilsson, P. M., Deloukas, P., Thorsteinsdottir, U., Groop, L. C., Stefansson, K., Hu, F., Pankow, J. S., Dupuis, J., Meigs, J. B., Altshuler, D., Boehnke, M., McCarthy, M. I., & DIAbet Genetics Replication, Asian Genetic Epidemiology, Genetic Invest ANthropometric, Meta-Anal Glucose Insulin-Related, S Asian Type 2 Diabet SAT2D, Wellcome Trust Case Control (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981-990doi: 10.1038/ng.2383

Vancouver

Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics. 2012 Sep;44(9):981-990.

Author

Morris, Andrew P.; Voight, Benjamin F.; Teslovich, Tanya M.; Ferreira, Teresa; Segre, Ayellet V.; Steinthorsdottir, Valgerdur; Strawbridge, Rona J.; Khan, Hassan; Grallert, Harald; Mahajan, Anubha; Prokopenko, Inga; Kang, Hyun Min; Dina, Christian; Esko, Tonu; Fraser, Ross M.; Kanoni, Stavroula; Kumar, Ashish; Lagou, Vasiliki; Langenberg, Claudia; Luan, Jian'an; Lindgren, Cecilia M.; Mueller-Nurasyid, Martina; Pechlivanis, Sonali; Rayner, N. William; Scott, Laura J.; Wiltshire, Steven; Yengo, Loic; Kinnunen, Leena; Rossin, Elizabeth J.; Raychaudhuri, Soumya; Johnson, Andrew D.; Dimas, Antigone S.; Loos, Ruth J. F.; Vedantam, Sailaja; Chen, Han; Florez, Jose C.; Fox, Caroline; Liu, Ching-Ti; Rybin, Denis; Couper, David J.; Kao, Wen Hong L.; Li, Man; Cornelis, Marilyn C.; Kraft, Peter; Sun, Qi; van Dam, Rob M.; Stringham, Heather M.; Chines, Peter S.; Fischer, Krista; Fontanillas, Pierre; Holmen, Oddgeir L.; Hunt, Sarah E.; Jackson, Anne U.; Kong, Augustine; Lawrence, Robert; Meyer, Julia; Perry, John R. B.; Platou, Carl G. P.; Potter, Simon; Rehnberg, Emil; Robertson, Neil; Sivapalaratnam, Suthesh; Stancakova, Alena; Stirrups, Kathleen; Thorleifsson, Gudmar; Tikkanen, Emmi; Wood, Andrew R.; Almgren, Peter; Atalay, Mustafa; Benediktsson, Rafn; Bonnycastle, Lori L.; Burtt, Noel; Carey, Jason; Charpentier, Guillaume; Crenshaw, Andrew T.; Doney, Alex S. F.; Dorkhan, Mozhgan; Edkins, Sarah; Emilsson, Valur; Eury, Elodie; Forsen, Tom; Gertow, Karl; Gigante, Bruna; Grant, George B.; Groves, Christopher J.; Guiducci, Candace; Herder, Christian; Hreidarsson, Astradur B.; Hui, Jennie; James, Alan; Jonsson, Anna; Rathmann, Wolfgang; Klopp, Norman; Kravic, Jasmina; Krjutskov, Kaarel; Langford, Cordelia; Leander, Karin; Lindholm, Eero; Lobbens, Stephane; Mannisto, Satu; Mirza, Ghazala; Mühleisen, Thomas W.; Musk, Bill; Parkin, Melissa; Rallidis, Loukianos; Saramies, Jouko; Sennblad, Bengt; Shah, Sonia; Sigurdsson, Gunnar; Silveira, Angela; Steinbach, Gerald; Thorand, Barbara; Trakalo, Joseph; Veglia, Fabrizio; Wennauer, Roman; Winckler, Wendy; Zabaneh, Delilah; Campbell, Harry; van Duijn, Cornelia; Uitterlinden, Andre G.; Hofman, Albert; Sijbrands, Eric; Abecasis, Goncalo R.; Owen, Katharine R.; Zeggini, Eleftheria; Trip, Mieke D.; Forouhi, Nita G.; Syvanen, Ann-Christine; Eriksson, Johan G.; Peltonen, Leena; Noethen, Markus M.; Balkau, Beverley; Palmer, Colin N. A.; Lyssenko, Valeriya; Tuomi, Tiinamaija; Isomaa, Bo; Hunter, David J.; Qi, Lu; Shuldiner, Alan R.; Roden, Michael; Barroso, Ines; Wilsgaard, Tom; Beilby, John; Hovingh, Kees; Price, Jackie F.; Wilson, James F.; Rauramaa, Rainer; Lakka, Timo A.; Lind, Lars; Dedoussis, George; Njolstad, Inger; Pedersen, Nancy L.; Khaw, Kay-Tee; Wareham, Nicholas J.; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Korpi-Hyovalti, Eeva; Saltevo, Juha; Laakso, Markku; Kuusisto, Johanna; Metspalu, Andres; Collins, Francis S.; Mohlke, Karen L.; Bergman, Richard N.; Tuomilehto, Jaakko; Boehm, Bernhard O.; Gieger, Christian; Hveem, Kristian; Cauchi, Stephane; Froguel, Philippe; Baldassarre, Damiano; Tremoli, Elena; Humphries, Steve E.; Saleheen, Danish; Danesh, John; Ingelsson, Erik; Ripatti, Samuli; Salomaa, Veikko; Erbel, Raimund; Jöckel, Karl-Heinz; Moebus, Susanne; Peters, Annette; Illig, Thomas; de Faire, Ulf; Hamsten, Anders; Morris, Andrew D.; Donnelly, Peter J.; Frayling, Timothy M.; Hattersley, Andrew T.; Boerwinkle, Eric; Melander, Olle; Kathiresan, Sekar; Nilsson, Peter M.; Deloukas, Panos; Thorsteinsdottir, Unnur; Groop, Leif C.; Stefansson, Kari; Hu, Frank; Pankow, James S.; Dupuis, Josee; Meigs, James B.; Altshuler, David; Boehnke, Michael; McCarthy, Mark I.; DIAbet Genetics Replication, Asian Genetic Epidemiology, Genetic Invest ANthropometric, Meta-Anal Glucose Insulin-Related, S Asian Type 2 Diabet SAT2D, Wellcome Trust Case Control / Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

In: Nature Genetics, Vol. 44, No. 9, 09.2012, p. 981-990.

Research output: Contribution to journalArticle

Bibtex - Download

@article{5532ec264f1045a39d28d8799c3ec3f2,
title = "Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes",
author = "Morris, {Andrew P.} and Voight, {Benjamin F.} and Teslovich, {Tanya M.} and Teresa Ferreira and Segre, {Ayellet V.} and Valgerdur Steinthorsdottir and Strawbridge, {Rona J.} and Hassan Khan and Harald Grallert and Anubha Mahajan and Inga Prokopenko and Kang, {Hyun Min} and Christian Dina and Tonu Esko and Fraser, {Ross M.} and Stavroula Kanoni and Ashish Kumar and Vasiliki Lagou and Claudia Langenberg and Jian'an Luan and Lindgren, {Cecilia M.} and Martina Mueller-Nurasyid and Sonali Pechlivanis and Rayner, {N. William} and Scott, {Laura J.} and Steven Wiltshire and Loic Yengo and Leena Kinnunen and Rossin, {Elizabeth J.} and Soumya Raychaudhuri and Johnson, {Andrew D.} and Dimas, {Antigone S.} and Loos, {Ruth J. F.} and Sailaja Vedantam and Han Chen and Florez, {Jose C.} and Caroline Fox and Ching-Ti Liu and Denis Rybin and Couper, {David J.} and Kao, {Wen Hong L.} and Man Li and Cornelis, {Marilyn C.} and Peter Kraft and Qi Sun and {van Dam}, {Rob M.} and Stringham, {Heather M.} and Chines, {Peter S.} and Krista Fischer and Pierre Fontanillas and Holmen, {Oddgeir L.} and Hunt, {Sarah E.} and Jackson, {Anne U.} and Augustine Kong and Robert Lawrence and Julia Meyer and Perry, {John R. B.} and Platou, {Carl G. P.} and Simon Potter and Emil Rehnberg and Neil Robertson and Suthesh Sivapalaratnam and Alena Stancakova and Kathleen Stirrups and Gudmar Thorleifsson and Emmi Tikkanen and Wood, {Andrew R.} and Peter Almgren and Mustafa Atalay and Rafn Benediktsson and Bonnycastle, {Lori L.} and Noel Burtt and Jason Carey and Guillaume Charpentier and Crenshaw, {Andrew T.} and Doney, {Alex S. F.} and Mozhgan Dorkhan and Sarah Edkins and Valur Emilsson and Elodie Eury and Tom Forsen and Karl Gertow and Bruna Gigante and Grant, {George B.} and Groves, {Christopher J.} and Candace Guiducci and Christian Herder and Hreidarsson, {Astradur B.} and Jennie Hui and Alan James and Anna Jonsson and Wolfgang Rathmann and Norman Klopp and Jasmina Kravic and Kaarel Krjutskov and Cordelia Langford and Karin Leander and Eero Lindholm and Stephane Lobbens and Satu Mannisto and Ghazala Mirza and Mühleisen, {Thomas W.} and Bill Musk and Melissa Parkin and Loukianos Rallidis and Jouko Saramies and Bengt Sennblad and Sonia Shah and Gunnar Sigurdsson and Angela Silveira and Gerald Steinbach and Barbara Thorand and Joseph Trakalo and Fabrizio Veglia and Roman Wennauer and Wendy Winckler and Delilah Zabaneh and Harry Campbell and {van Duijn}, Cornelia and Uitterlinden, {Andre G.} and Albert Hofman and Eric Sijbrands and Abecasis, {Goncalo R.} and Owen, {Katharine R.} and Eleftheria Zeggini and Trip, {Mieke D.} and Forouhi, {Nita G.} and Ann-Christine Syvanen and Eriksson, {Johan G.} and Leena Peltonen and Noethen, {Markus M.} and Beverley Balkau and Palmer, {Colin N. A.} and Valeriya Lyssenko and Tiinamaija Tuomi and Bo Isomaa and Hunter, {David J.} and Lu Qi and Shuldiner, {Alan R.} and Michael Roden and Ines Barroso and Tom Wilsgaard and John Beilby and Kees Hovingh and Price, {Jackie F.} and Wilson, {James F.} and Rainer Rauramaa and Lakka, {Timo A.} and Lars Lind and George Dedoussis and Inger Njolstad and Pedersen, {Nancy L.} and Kay-Tee Khaw and Wareham, {Nicholas J.} and Keinanen-Kiukaanniemi, {Sirkka M.} and Saaristo, {Timo E.} and Eeva Korpi-Hyovalti and Juha Saltevo and Markku Laakso and Johanna Kuusisto and Andres Metspalu and Collins, {Francis S.} and Mohlke, {Karen L.} and Bergman, {Richard N.} and Jaakko Tuomilehto and Boehm, {Bernhard O.} and Christian Gieger and Kristian Hveem and Stephane Cauchi and Philippe Froguel and Damiano Baldassarre and Elena Tremoli and Humphries, {Steve E.} and Danish Saleheen and John Danesh and Erik Ingelsson and Samuli Ripatti and Veikko Salomaa and Raimund Erbel and Karl-Heinz Jöckel and Susanne Moebus and Annette Peters and Thomas Illig and {de Faire}, Ulf and Anders Hamsten and Morris, {Andrew D.} and Donnelly, {Peter J.} and Frayling, {Timothy M.} and Hattersley, {Andrew T.} and Eric Boerwinkle and Olle Melander and Sekar Kathiresan and Nilsson, {Peter M.} and Panos Deloukas and Unnur Thorsteinsdottir and Groop, {Leif C.} and Kari Stefansson and Frank Hu and Pankow, {James S.} and Josee Dupuis and Meigs, {James B.} and David Altshuler and Michael Boehnke and McCarthy, {Mark I.} and {DIAbet Genetics Replication, Asian Genetic Epidemiology, Genetic Invest ANthropometric, Meta-Anal Glucose Insulin-Related, S Asian Type 2 Diabet SAT2D, Wellcome Trust Case Control}",
year = "2012",
volume = "44",
number = "9",
pages = "981--990",
journal = "Nature Genetics",
issn = "1061-4036",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

A1 - Morris,Andrew P.

A1 - Voight,Benjamin F.

A1 - Teslovich,Tanya M.

A1 - Ferreira,Teresa

A1 - Segre,Ayellet V.

A1 - Steinthorsdottir,Valgerdur

A1 - Strawbridge,Rona J.

A1 - Khan,Hassan

A1 - Grallert,Harald

A1 - Mahajan,Anubha

A1 - Prokopenko,Inga

A1 - Kang,Hyun Min

A1 - Dina,Christian

A1 - Esko,Tonu

A1 - Fraser,Ross M.

A1 - Kanoni,Stavroula

A1 - Kumar,Ashish

A1 - Lagou,Vasiliki

A1 - Langenberg,Claudia

A1 - Luan,Jian'an

A1 - Lindgren,Cecilia M.

A1 - Mueller-Nurasyid,Martina

A1 - Pechlivanis,Sonali

A1 - Rayner,N. William

A1 - Scott,Laura J.

A1 - Wiltshire,Steven

A1 - Yengo,Loic

A1 - Kinnunen,Leena

A1 - Rossin,Elizabeth J.

A1 - Raychaudhuri,Soumya

A1 - Johnson,Andrew D.

A1 - Dimas,Antigone S.

A1 - Loos,Ruth J. F.

A1 - Vedantam,Sailaja

A1 - Chen,Han

A1 - Florez,Jose C.

A1 - Fox,Caroline

A1 - Liu,Ching-Ti

A1 - Rybin,Denis

A1 - Couper,David J.

A1 - Kao,Wen Hong L.

A1 - Li,Man

A1 - Cornelis,Marilyn C.

A1 - Kraft,Peter

A1 - Sun,Qi

A1 - van Dam,Rob M.

A1 - Stringham,Heather M.

A1 - Chines,Peter S.

A1 - Fischer,Krista

A1 - Fontanillas,Pierre

A1 - Holmen,Oddgeir L.

A1 - Hunt,Sarah E.

A1 - Jackson,Anne U.

A1 - Kong,Augustine

A1 - Lawrence,Robert

A1 - Meyer,Julia

A1 - Perry,John R. B.

A1 - Platou,Carl G. P.

A1 - Potter,Simon

A1 - Rehnberg,Emil

A1 - Robertson,Neil

A1 - Sivapalaratnam,Suthesh

A1 - Stancakova,Alena

A1 - Stirrups,Kathleen

A1 - Thorleifsson,Gudmar

A1 - Tikkanen,Emmi

A1 - Wood,Andrew R.

A1 - Almgren,Peter

A1 - Atalay,Mustafa

A1 - Benediktsson,Rafn

A1 - Bonnycastle,Lori L.

A1 - Burtt,Noel

A1 - Carey,Jason

A1 - Charpentier,Guillaume

A1 - Crenshaw,Andrew T.

A1 - Doney,Alex S. F.

A1 - Dorkhan,Mozhgan

A1 - Edkins,Sarah

A1 - Emilsson,Valur

A1 - Eury,Elodie

A1 - Forsen,Tom

A1 - Gertow,Karl

A1 - Gigante,Bruna

A1 - Grant,George B.

A1 - Groves,Christopher J.

A1 - Guiducci,Candace

A1 - Herder,Christian

A1 - Hreidarsson,Astradur B.

A1 - Hui,Jennie

A1 - James,Alan

A1 - Jonsson,Anna

A1 - Rathmann,Wolfgang

A1 - Klopp,Norman

A1 - Kravic,Jasmina

A1 - Krjutskov,Kaarel

A1 - Langford,Cordelia

A1 - Leander,Karin

A1 - Lindholm,Eero

A1 - Lobbens,Stephane

A1 - Mannisto,Satu

A1 - Mirza,Ghazala

A1 - Mühleisen,Thomas W.

A1 - Musk,Bill

A1 - Parkin,Melissa

A1 - Rallidis,Loukianos

A1 - Saramies,Jouko

A1 - Sennblad,Bengt

A1 - Shah,Sonia

A1 - Sigurdsson,Gunnar

A1 - Silveira,Angela

A1 - Steinbach,Gerald

A1 - Thorand,Barbara

A1 - Trakalo,Joseph

A1 - Veglia,Fabrizio

A1 - Wennauer,Roman

A1 - Winckler,Wendy

A1 - Zabaneh,Delilah

A1 - Campbell,Harry

A1 - van Duijn,Cornelia

A1 - Uitterlinden,Andre G.

A1 - Hofman,Albert

A1 - Sijbrands,Eric

A1 - Abecasis,Goncalo R.

A1 - Owen,Katharine R.

A1 - Zeggini,Eleftheria

A1 - Trip,Mieke D.

A1 - Forouhi,Nita G.

A1 - Syvanen,Ann-Christine

A1 - Eriksson,Johan G.

A1 - Peltonen,Leena

A1 - Noethen,Markus M.

A1 - Balkau,Beverley

A1 - Palmer,Colin N. A.

A1 - Lyssenko,Valeriya

A1 - Tuomi,Tiinamaija

A1 - Isomaa,Bo

A1 - Hunter,David J.

A1 - Qi,Lu

A1 - Shuldiner,Alan R.

A1 - Roden,Michael

A1 - Barroso,Ines

A1 - Wilsgaard,Tom

A1 - Beilby,John

A1 - Hovingh,Kees

A1 - Price,Jackie F.

A1 - Wilson,James F.

A1 - Rauramaa,Rainer

A1 - Lakka,Timo A.

A1 - Lind,Lars

A1 - Dedoussis,George

A1 - Njolstad,Inger

A1 - Pedersen,Nancy L.

A1 - Khaw,Kay-Tee

A1 - Wareham,Nicholas J.

A1 - Keinanen-Kiukaanniemi,Sirkka M.

A1 - Saaristo,Timo E.

A1 - Korpi-Hyovalti,Eeva

A1 - Saltevo,Juha

A1 - Laakso,Markku

A1 - Kuusisto,Johanna

A1 - Metspalu,Andres

A1 - Collins,Francis S.

A1 - Mohlke,Karen L.

A1 - Bergman,Richard N.

A1 - Tuomilehto,Jaakko

A1 - Boehm,Bernhard O.

A1 - Gieger,Christian

A1 - Hveem,Kristian

A1 - Cauchi,Stephane

A1 - Froguel,Philippe

A1 - Baldassarre,Damiano

A1 - Tremoli,Elena

A1 - Humphries,Steve E.

A1 - Saleheen,Danish

A1 - Danesh,John

A1 - Ingelsson,Erik

A1 - Ripatti,Samuli

A1 - Salomaa,Veikko

A1 - Erbel,Raimund

A1 - Jöckel,Karl-Heinz

A1 - Moebus,Susanne

A1 - Peters,Annette

A1 - Illig,Thomas

A1 - de Faire,Ulf

A1 - Hamsten,Anders

A1 - Morris,Andrew D.

A1 - Donnelly,Peter J.

A1 - Frayling,Timothy M.

A1 - Hattersley,Andrew T.

A1 - Boerwinkle,Eric

A1 - Melander,Olle

A1 - Kathiresan,Sekar

A1 - Nilsson,Peter M.

A1 - Deloukas,Panos

A1 - Thorsteinsdottir,Unnur

A1 - Groop,Leif C.

A1 - Stefansson,Kari

A1 - Hu,Frank

A1 - Pankow,James S.

A1 - Dupuis,Josee

A1 - Meigs,James B.

A1 - Altshuler,David

A1 - Boehnke,Michael

A1 - McCarthy,Mark I.

A1 - DIAbet Genetics Replication, Asian Genetic Epidemiology, Genetic Invest ANthropometric, Meta-Anal Glucose Insulin-Related, S Asian Type 2 Diabet SAT2D, Wellcome Trust Case Control

AU - Morris,Andrew P.

AU - Voight,Benjamin F.

AU - Teslovich,Tanya M.

AU - Ferreira,Teresa

AU - Segre,Ayellet V.

AU - Steinthorsdottir,Valgerdur

AU - Strawbridge,Rona J.

AU - Khan,Hassan

AU - Grallert,Harald

AU - Mahajan,Anubha

AU - Prokopenko,Inga

AU - Kang,Hyun Min

AU - Dina,Christian

AU - Esko,Tonu

AU - Fraser,Ross M.

AU - Kanoni,Stavroula

AU - Kumar,Ashish

AU - Lagou,Vasiliki

AU - Langenberg,Claudia

AU - Luan,Jian'an

AU - Lindgren,Cecilia M.

AU - Mueller-Nurasyid,Martina

AU - Pechlivanis,Sonali

AU - Rayner,N. William

AU - Scott,Laura J.

AU - Wiltshire,Steven

AU - Yengo,Loic

AU - Kinnunen,Leena

AU - Rossin,Elizabeth J.

AU - Raychaudhuri,Soumya

AU - Johnson,Andrew D.

AU - Dimas,Antigone S.

AU - Loos,Ruth J. F.

AU - Vedantam,Sailaja

AU - Chen,Han

AU - Florez,Jose C.

AU - Fox,Caroline

AU - Liu,Ching-Ti

AU - Rybin,Denis

AU - Couper,David J.

AU - Kao,Wen Hong L.

AU - Li,Man

AU - Cornelis,Marilyn C.

AU - Kraft,Peter

AU - Sun,Qi

AU - van Dam,Rob M.

AU - Stringham,Heather M.

AU - Chines,Peter S.

AU - Fischer,Krista

AU - Fontanillas,Pierre

AU - Holmen,Oddgeir L.

AU - Hunt,Sarah E.

AU - Jackson,Anne U.

AU - Kong,Augustine

AU - Lawrence,Robert

AU - Meyer,Julia

AU - Perry,John R. B.

AU - Platou,Carl G. P.

AU - Potter,Simon

AU - Rehnberg,Emil

AU - Robertson,Neil

AU - Sivapalaratnam,Suthesh

AU - Stancakova,Alena

AU - Stirrups,Kathleen

AU - Thorleifsson,Gudmar

AU - Tikkanen,Emmi

AU - Wood,Andrew R.

AU - Almgren,Peter

AU - Atalay,Mustafa

AU - Benediktsson,Rafn

AU - Bonnycastle,Lori L.

AU - Burtt,Noel

AU - Carey,Jason

AU - Charpentier,Guillaume

AU - Crenshaw,Andrew T.

AU - Doney,Alex S. F.

AU - Dorkhan,Mozhgan

AU - Edkins,Sarah

AU - Emilsson,Valur

AU - Eury,Elodie

AU - Forsen,Tom

AU - Gertow,Karl

AU - Gigante,Bruna

AU - Grant,George B.

AU - Groves,Christopher J.

AU - Guiducci,Candace

AU - Herder,Christian

AU - Hreidarsson,Astradur B.

AU - Hui,Jennie

AU - James,Alan

AU - Jonsson,Anna

AU - Rathmann,Wolfgang

AU - Klopp,Norman

AU - Kravic,Jasmina

AU - Krjutskov,Kaarel

AU - Langford,Cordelia

AU - Leander,Karin

AU - Lindholm,Eero

AU - Lobbens,Stephane

AU - Mannisto,Satu

AU - Mirza,Ghazala

AU - Mühleisen,Thomas W.

AU - Musk,Bill

AU - Parkin,Melissa

AU - Rallidis,Loukianos

AU - Saramies,Jouko

AU - Sennblad,Bengt

AU - Shah,Sonia

AU - Sigurdsson,Gunnar

AU - Silveira,Angela

AU - Steinbach,Gerald

AU - Thorand,Barbara

AU - Trakalo,Joseph

AU - Veglia,Fabrizio

AU - Wennauer,Roman

AU - Winckler,Wendy

AU - Zabaneh,Delilah

AU - Campbell,Harry

AU - van Duijn,Cornelia

AU - Uitterlinden,Andre G.

AU - Hofman,Albert

AU - Sijbrands,Eric

AU - Abecasis,Goncalo R.

AU - Owen,Katharine R.

AU - Zeggini,Eleftheria

AU - Trip,Mieke D.

AU - Forouhi,Nita G.

AU - Syvanen,Ann-Christine

AU - Eriksson,Johan G.

AU - Peltonen,Leena

AU - Noethen,Markus M.

AU - Balkau,Beverley

AU - Palmer,Colin N. A.

AU - Lyssenko,Valeriya

AU - Tuomi,Tiinamaija

AU - Isomaa,Bo

AU - Hunter,David J.

AU - Qi,Lu

AU - Shuldiner,Alan R.

AU - Roden,Michael

AU - Barroso,Ines

AU - Wilsgaard,Tom

AU - Beilby,John

AU - Hovingh,Kees

AU - Price,Jackie F.

AU - Wilson,James F.

AU - Rauramaa,Rainer

AU - Lakka,Timo A.

AU - Lind,Lars

AU - Dedoussis,George

AU - Njolstad,Inger

AU - Pedersen,Nancy L.

AU - Khaw,Kay-Tee

AU - Wareham,Nicholas J.

AU - Keinanen-Kiukaanniemi,Sirkka M.

AU - Saaristo,Timo E.

AU - Korpi-Hyovalti,Eeva

AU - Saltevo,Juha

AU - Laakso,Markku

AU - Kuusisto,Johanna

AU - Metspalu,Andres

AU - Collins,Francis S.

AU - Mohlke,Karen L.

AU - Bergman,Richard N.

AU - Tuomilehto,Jaakko

AU - Boehm,Bernhard O.

AU - Gieger,Christian

AU - Hveem,Kristian

AU - Cauchi,Stephane

AU - Froguel,Philippe

AU - Baldassarre,Damiano

AU - Tremoli,Elena

AU - Humphries,Steve E.

AU - Saleheen,Danish

AU - Danesh,John

AU - Ingelsson,Erik

AU - Ripatti,Samuli

AU - Salomaa,Veikko

AU - Erbel,Raimund

AU - Jöckel,Karl-Heinz

AU - Moebus,Susanne

AU - Peters,Annette

AU - Illig,Thomas

AU - de Faire,Ulf

AU - Hamsten,Anders

AU - Morris,Andrew D.

AU - Donnelly,Peter J.

AU - Frayling,Timothy M.

AU - Hattersley,Andrew T.

AU - Boerwinkle,Eric

AU - Melander,Olle

AU - Kathiresan,Sekar

AU - Nilsson,Peter M.

AU - Deloukas,Panos

AU - Thorsteinsdottir,Unnur

AU - Groop,Leif C.

AU - Stefansson,Kari

AU - Hu,Frank

AU - Pankow,James S.

AU - Dupuis,Josee

AU - Meigs,James B.

AU - Altshuler,David

AU - Boehnke,Michael

AU - McCarthy,Mark I.

AU - DIAbet Genetics Replication, Asian Genetic Epidemiology, Genetic Invest ANthropometric, Meta-Anal Glucose Insulin-Related, S Asian Type 2 Diabet SAT2D, Wellcome Trust Case Control

PY - 2012/9

Y1 - 2012/9

N2 - <p>To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.</p>

AB - <p>To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.</p>

U2 - 10.1038/ng.2383

DO - 10.1038/ng.2383

M1 - Article

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

VL - 44

SP - 981

EP - 990

ER -

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