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Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

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Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. / Sklar, Pamela; Ripke, Stephan; Scott, Laura J.; Andreassen, Ole A.; Cichon, Sven; Craddock, Nick; Edenberg, Howard J.; Nurnberger, John I.; Rietschel, Marcella; Blackwood, Douglas; Corvin, Aiden; Flickinger, Matthew; Guan, Weihua; Mattingsdal, Morten; McQuillin, Andrew; Kwan, Phoenix; Wienker, Thomas F.; Daly, Mark; Dudbridge, Frank; Holmans, Peter A.; Lin, Danyu; Burmeister, Margit; Greenwood, Tiffany A.; Hamshere, Marian L.; Muglia, Pierandrea; Smith, Erin N.; Zandi, Peter P.; Nievergelt, Caroline M.; McKinney, Rebecca; Shilling, Paul D.; Schork, Nicholas J.; Bloss, Cinnamon S.; Foroud, Tatiana; Koller, Daniel L.; Gershon, Elliot S.; Liu, Chunyu; Badner, Judith A.; Scheftner, William A.; Lawson, William B.; Nwulia, Evaristus A.; Hipolito, Maria; Coryell, William; Rice, John; Byerley, William; McMahon, Francis J.; Schulze, Thomas G.; Berrettini, Wade; Lohoff, Falk W.; Potash, James B.; Mahon, Pamela B.; McInnis, Melvin G.; Zoellner, Sebastian; Zhang, Peng; Craig, David W.; Szelinger, Szabocls; Barrett, Thomas B.; Breuer, Rene; Meier, Sandra; Strohmaier, Jana; Witt, Stephanie H.; Tozzi, Federica; Farmer, Anne; McGuffin, Peter; Strauss, John; Xu, Wei; Kennedy, James L.; Vincent, John B.; Matthews, Keith; Day, Richard; Ferreira, Manuel A.; O'Dushlaine, Colm; Perlis, Roy; Raychaudhuri, Soumya; Ruderfer, Douglas; Lee, Phil H.; Smoller, Jordan W.; Li, Jun; Absher, Devin; Bunney, William E.; Barchas, Jack D.; Schatzberg, Alan F.; Jones, Edward G.; Meng, Fan Guo; Thompson, Robert C.; Watson, Stanley J.; Myers, Richard M.; Akil, Huda; Boehnke, Michael; Chambert, Kim; Moran, Jennifer; Scolnick, Ed; Djurovic, Srdjan; Melle, Ingrid; Morken, Gunnar; Gill, Michael; Morris, Derek; Quinn, Emma; Mühleisen, Thomas W.; Degenhardt, Franziska A.; Mattheisen, Manuel; Schumacher, Johannes; Maier, Wolfgang; Steffens, Michael; Propping, Peter; Noethen, Markus M.; Anjorin, Adebayo; Bass, Nick; Gurling, Hugh; Kandaswamy, Radhika; Lawrence, Jacob; McGhee, Kevin; McIntosh, Andrew; McLean, Alan W.; Muir, Walter J.; Pickard, Benjamin S.; Breen, Gerome; St Clair, David; Caesar, Sian; Gordon-Smith, Katherine; Jones, Lisa; Fraser, Christine; Green, Elaine K.; Grozeva, Detelina; Jones, Ian R.; Kirov, George; Moskvina, Valentina; Nikolov, Ivan; O'Donovan, Michael C.; Owen, Michael J.; Collier, David A.; Elkin, Amanda; Matthews, Keith; Young, Allan H.; Ferrier, I. Nicol; Williamson, Richard; Stefansson, Kari; Stefansson, Hreinn; Porgeirsson, Porgeir; Steinberg, Stacy; Gustafsson, Omar; Bergen, Sarah E.; Nimgaonkar, Vishwajit; Hultman, Christina; Landen, Mikael; Lichtenstein, Paul; Sullivan, Patrick; Schalling, Martin; Osby, Urban; Backlund, Lena; Frisen, Louise; Langstrom, Niklas; Jamain, Stephane; Leboyer, Marion; Etain, Bruno; Bellivier, Frank; Petursson, Hannes; Sigurosson, Engilbert; Mueller-Mysok, Bertram; Lucae, Susanne; Schwarz, Markus; Schofield, Peter R.; Martin, Nick; Montgomery, Grant W.; Lathrop, Mark; Oskarsson, Hogni; Bauer, Michael; Wright, Adam; Mitchell, Philip B.; Hautzinger, Martin; Reif, Andreas; Kelsoe, John R.; Purcell, Shaun M.; Psychiat GWAS Consortium Bipolar D.

In: Nature Genetics, Vol. 43, No. 10, 10.2011, p. 977-983.

Research output: Contribution to journalArticle

Harvard

Sklar, P, Ripke, S, Scott, LJ, Andreassen, OA, Cichon, S, Craddock, N, Edenberg, HJ, Nurnberger, JI, Rietschel, M, Blackwood, D, Corvin, A, Flickinger, M, Guan, W, Mattingsdal, M, McQuillin, A, Kwan, P, Wienker, TF, Daly, M, Dudbridge, F, Holmans, PA, Lin, D, Burmeister, M, Greenwood, TA, Hamshere, ML, Muglia, P, Smith, EN, Zandi, PP, Nievergelt, CM, McKinney, R, Shilling, PD, Schork, NJ, Bloss, CS, Foroud, T, Koller, DL, Gershon, ES, Liu, C, Badner, JA, Scheftner, WA, Lawson, WB, Nwulia, EA, Hipolito, M, Coryell, W, Rice, J, Byerley, W, McMahon, FJ, Schulze, TG, Berrettini, W, Lohoff, FW, Potash, JB, Mahon, PB, McInnis, MG, Zoellner, S, Zhang, P, Craig, DW, Szelinger, S, Barrett, TB, Breuer, R, Meier, S, Strohmaier, J, Witt, SH, Tozzi, F, Farmer, A, McGuffin, P, Strauss, J, Xu, W, Kennedy, JL, Vincent, JB, Matthews, K, Day, R, Ferreira, MA, O'Dushlaine, C, Perlis, R, Raychaudhuri, S, Ruderfer, D, Lee, PH, Smoller, JW, Li, J, Absher, D, Bunney, WE, Barchas, JD, Schatzberg, AF, Jones, EG, Meng, FG, Thompson, RC, Watson, SJ, Myers, RM, Akil, H, Boehnke, M, Chambert, K, Moran, J, Scolnick, E, Djurovic, S, Melle, I, Morken, G, Gill, M, Morris, D, Quinn, E, Mühleisen, TW, Degenhardt, FA, Mattheisen, M, Schumacher, J, Maier, W, Steffens, M, Propping, P, Noethen, MM, Anjorin, A, Bass, N, Gurling, H, Kandaswamy, R, Lawrence, J, McGhee, K, McIntosh, A, McLean, AW, Muir, WJ, Pickard, BS, Breen, G, St Clair, D, Caesar, S, Gordon-Smith, K, Jones, L, Fraser, C, Green, EK, Grozeva, D, Jones, IR, Kirov, G, Moskvina, V, Nikolov, I, O'Donovan, MC, Owen, MJ, Collier, DA, Elkin, A, Matthews, K, Young, AH, Ferrier, IN, Williamson, R, Stefansson, K, Stefansson, H, Porgeirsson, P, Steinberg, S, Gustafsson, O, Bergen, SE, Nimgaonkar, V, Hultman, C, Landen, M, Lichtenstein, P, Sullivan, P, Schalling, M, Osby, U, Backlund, L, Frisen, L, Langstrom, N, Jamain, S, Leboyer, M, Etain, B, Bellivier, F, Petursson, H, Sigurosson, E, Mueller-Mysok, B, Lucae, S, Schwarz, M, Schofield, PR, Martin, N, Montgomery, GW, Lathrop, M, Oskarsson, H, Bauer, M, Wright, A, Mitchell, PB, Hautzinger, M, Reif, A, Kelsoe, JR, Purcell, SM & Psychiat GWAS Consortium Bipolar D 2011, 'Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4' Nature Genetics, vol 43, no. 10, pp. 977-983., 10.1038/ng.943

APA

Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., ... Psychiat GWAS Consortium Bipolar D (2011). Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nature Genetics, 43(10), 977-983. 10.1038/ng.943

Vancouver

Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nature Genetics. 2011 Oct;43(10):977-983. Available from: 10.1038/ng.943

Author

Sklar, Pamela; Ripke, Stephan; Scott, Laura J.; Andreassen, Ole A.; Cichon, Sven; Craddock, Nick; Edenberg, Howard J.; Nurnberger, John I.; Rietschel, Marcella; Blackwood, Douglas; Corvin, Aiden; Flickinger, Matthew; Guan, Weihua; Mattingsdal, Morten; McQuillin, Andrew; Kwan, Phoenix; Wienker, Thomas F.; Daly, Mark; Dudbridge, Frank; Holmans, Peter A.; Lin, Danyu; Burmeister, Margit; Greenwood, Tiffany A.; Hamshere, Marian L.; Muglia, Pierandrea; Smith, Erin N.; Zandi, Peter P.; Nievergelt, Caroline M.; McKinney, Rebecca; Shilling, Paul D.; Schork, Nicholas J.; Bloss, Cinnamon S.; Foroud, Tatiana; Koller, Daniel L.; Gershon, Elliot S.; Liu, Chunyu; Badner, Judith A.; Scheftner, William A.; Lawson, William B.; Nwulia, Evaristus A.; Hipolito, Maria; Coryell, William; Rice, John; Byerley, William; McMahon, Francis J.; Schulze, Thomas G.; Berrettini, Wade; Lohoff, Falk W.; Potash, James B.; Mahon, Pamela B.; McInnis, Melvin G.; Zoellner, Sebastian; Zhang, Peng; Craig, David W.; Szelinger, Szabocls; Barrett, Thomas B.; Breuer, Rene; Meier, Sandra; Strohmaier, Jana; Witt, Stephanie H.; Tozzi, Federica; Farmer, Anne; McGuffin, Peter; Strauss, John; Xu, Wei; Kennedy, James L.; Vincent, John B.; Matthews, Keith; Day, Richard; Ferreira, Manuel A.; O'Dushlaine, Colm; Perlis, Roy; Raychaudhuri, Soumya; Ruderfer, Douglas; Lee, Phil H.; Smoller, Jordan W.; Li, Jun; Absher, Devin; Bunney, William E.; Barchas, Jack D.; Schatzberg, Alan F.; Jones, Edward G.; Meng, Fan Guo; Thompson, Robert C.; Watson, Stanley J.; Myers, Richard M.; Akil, Huda; Boehnke, Michael; Chambert, Kim; Moran, Jennifer; Scolnick, Ed; Djurovic, Srdjan; Melle, Ingrid; Morken, Gunnar; Gill, Michael; Morris, Derek; Quinn, Emma; Mühleisen, Thomas W.; Degenhardt, Franziska A.; Mattheisen, Manuel; Schumacher, Johannes; Maier, Wolfgang; Steffens, Michael; Propping, Peter; Noethen, Markus M.; Anjorin, Adebayo; Bass, Nick; Gurling, Hugh; Kandaswamy, Radhika; Lawrence, Jacob; McGhee, Kevin; McIntosh, Andrew; McLean, Alan W.; Muir, Walter J.; Pickard, Benjamin S.; Breen, Gerome; St Clair, David; Caesar, Sian; Gordon-Smith, Katherine; Jones, Lisa; Fraser, Christine; Green, Elaine K.; Grozeva, Detelina; Jones, Ian R.; Kirov, George; Moskvina, Valentina; Nikolov, Ivan; O'Donovan, Michael C.; Owen, Michael J.; Collier, David A.; Elkin, Amanda; Matthews, Keith; Young, Allan H.; Ferrier, I. Nicol; Williamson, Richard; Stefansson, Kari; Stefansson, Hreinn; Porgeirsson, Porgeir; Steinberg, Stacy; Gustafsson, Omar; Bergen, Sarah E.; Nimgaonkar, Vishwajit; Hultman, Christina; Landen, Mikael; Lichtenstein, Paul; Sullivan, Patrick; Schalling, Martin; Osby, Urban; Backlund, Lena; Frisen, Louise; Langstrom, Niklas; Jamain, Stephane; Leboyer, Marion; Etain, Bruno; Bellivier, Frank; Petursson, Hannes; Sigurosson, Engilbert; Mueller-Mysok, Bertram; Lucae, Susanne; Schwarz, Markus; Schofield, Peter R.; Martin, Nick; Montgomery, Grant W.; Lathrop, Mark; Oskarsson, Hogni; Bauer, Michael; Wright, Adam; Mitchell, Philip B.; Hautzinger, Martin; Reif, Andreas; Kelsoe, John R.; Purcell, Shaun M.; Psychiat GWAS Consortium Bipolar D / Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

In: Nature Genetics, Vol. 43, No. 10, 10.2011, p. 977-983.

Research output: Contribution to journalArticle

Bibtex - Download

@article{9e956169850d4ad787817cad0250b1cc,
title = "Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4",
keywords = "PSYCHIATRIC-DISORDERS, SCHIZOPHRENIA, INDIVIDUALS, CACNA1C, RISK, PSYCHOSIS, GENETICS, ANK3",
author = "Pamela Sklar and Stephan Ripke and Scott, {Laura J.} and Andreassen, {Ole A.} and Sven Cichon and Nick Craddock and Edenberg, {Howard J.} and Nurnberger, {John I.} and Marcella Rietschel and Douglas Blackwood and Aiden Corvin and Matthew Flickinger and Weihua Guan and Morten Mattingsdal and Andrew McQuillin and Phoenix Kwan and Wienker, {Thomas F.} and Mark Daly and Frank Dudbridge and Holmans, {Peter A.} and Danyu Lin and Margit Burmeister and Greenwood, {Tiffany A.} and Hamshere, {Marian L.} and Pierandrea Muglia and Smith, {Erin N.} and Zandi, {Peter P.} and Nievergelt, {Caroline M.} and Rebecca McKinney and Shilling, {Paul D.} and Schork, {Nicholas J.} and Bloss, {Cinnamon S.} and Tatiana Foroud and Koller, {Daniel L.} and Gershon, {Elliot S.} and Chunyu Liu and Badner, {Judith A.} and Scheftner, {William A.} and Lawson, {William B.} and Nwulia, {Evaristus A.} and Maria Hipolito and William Coryell and John Rice and William Byerley and McMahon, {Francis J.} and Schulze, {Thomas G.} and Wade Berrettini and Lohoff, {Falk W.} and Potash, {James B.} and Mahon, {Pamela B.} and McInnis, {Melvin G.} and Sebastian Zoellner and Peng Zhang and Craig, {David W.} and Szabocls Szelinger and Barrett, {Thomas B.} and Rene Breuer and Sandra Meier and Jana Strohmaier and Witt, {Stephanie H.} and Federica Tozzi and Anne Farmer and Peter McGuffin and John Strauss and Wei Xu and Kennedy, {James L.} and Vincent, {John B.} and Keith Matthews and Richard Day and Ferreira, {Manuel A.} and Colm O'Dushlaine and Roy Perlis and Soumya Raychaudhuri and Douglas Ruderfer and Lee, {Phil H.} and Smoller, {Jordan W.} and Jun Li and Devin Absher and Bunney, {William E.} and Barchas, {Jack D.} and Schatzberg, {Alan F.} and Jones, {Edward G.} and Meng, {Fan Guo} and Thompson, {Robert C.} and Watson, {Stanley J.} and Myers, {Richard M.} and Huda Akil and Michael Boehnke and Kim Chambert and Jennifer Moran and Ed Scolnick and Srdjan Djurovic and Ingrid Melle and Gunnar Morken and Michael Gill and Derek Morris and Emma Quinn and Mühleisen, {Thomas W.} and Degenhardt, {Franziska A.} and Manuel Mattheisen and Johannes Schumacher and Wolfgang Maier and Michael Steffens and Peter Propping and Noethen, {Markus M.} and Adebayo Anjorin and Nick Bass and Hugh Gurling and Radhika Kandaswamy and Jacob Lawrence and Kevin McGhee and Andrew McIntosh and McLean, {Alan W.} and Muir, {Walter J.} and Pickard, {Benjamin S.} and Gerome Breen and {St Clair}, David and Sian Caesar and Katherine Gordon-Smith and Lisa Jones and Christine Fraser and Green, {Elaine K.} and Detelina Grozeva and Jones, {Ian R.} and George Kirov and Valentina Moskvina and Ivan Nikolov and O'Donovan, {Michael C.} and Owen, {Michael J.} and Collier, {David A.} and Amanda Elkin and Keith Matthews and Young, {Allan H.} and Ferrier, {I. Nicol} and Richard Williamson and Kari Stefansson and Hreinn Stefansson and Porgeir Porgeirsson and Stacy Steinberg and Omar Gustafsson and Bergen, {Sarah E.} and Vishwajit Nimgaonkar and Christina Hultman and Mikael Landen and Paul Lichtenstein and Patrick Sullivan and Martin Schalling and Urban Osby and Lena Backlund and Louise Frisen and Niklas Langstrom and Stephane Jamain and Marion Leboyer and Bruno Etain and Frank Bellivier and Hannes Petursson and Engilbert Sigurosson and Bertram Mueller-Mysok and Susanne Lucae and Markus Schwarz and Schofield, {Peter R.} and Nick Martin and Montgomery, {Grant W.} and Mark Lathrop and Hogni Oskarsson and Michael Bauer and Adam Wright and Mitchell, {Philip B.} and Martin Hautzinger and Andreas Reif and Kelsoe, {John R.} and Purcell, {Shaun M.} and {Psychiat GWAS Consortium Bipolar D}",
year = "2011",
month = "10",
doi = "10.1038/ng.943",
volume = "43",
pages = "977--983",
journal = "Nature Genetics",
issn = "1061-4036",
number = "10",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

AU - Sklar,Pamela

AU - Ripke,Stephan

AU - Scott,Laura J.

AU - Andreassen,Ole A.

AU - Cichon,Sven

AU - Craddock,Nick

AU - Edenberg,Howard J.

AU - Nurnberger,John I.

AU - Rietschel,Marcella

AU - Blackwood,Douglas

AU - Corvin,Aiden

AU - Flickinger,Matthew

AU - Guan,Weihua

AU - Mattingsdal,Morten

AU - McQuillin,Andrew

AU - Kwan,Phoenix

AU - Wienker,Thomas F.

AU - Daly,Mark

AU - Dudbridge,Frank

AU - Holmans,Peter A.

AU - Lin,Danyu

AU - Burmeister,Margit

AU - Greenwood,Tiffany A.

AU - Hamshere,Marian L.

AU - Muglia,Pierandrea

AU - Smith,Erin N.

AU - Zandi,Peter P.

AU - Nievergelt,Caroline M.

AU - McKinney,Rebecca

AU - Shilling,Paul D.

AU - Schork,Nicholas J.

AU - Bloss,Cinnamon S.

AU - Foroud,Tatiana

AU - Koller,Daniel L.

AU - Gershon,Elliot S.

AU - Liu,Chunyu

AU - Badner,Judith A.

AU - Scheftner,William A.

AU - Lawson,William B.

AU - Nwulia,Evaristus A.

AU - Hipolito,Maria

AU - Coryell,William

AU - Rice,John

AU - Byerley,William

AU - McMahon,Francis J.

AU - Schulze,Thomas G.

AU - Berrettini,Wade

AU - Lohoff,Falk W.

AU - Potash,James B.

AU - Mahon,Pamela B.

AU - McInnis,Melvin G.

AU - Zoellner,Sebastian

AU - Zhang,Peng

AU - Craig,David W.

AU - Szelinger,Szabocls

AU - Barrett,Thomas B.

AU - Breuer,Rene

AU - Meier,Sandra

AU - Strohmaier,Jana

AU - Witt,Stephanie H.

AU - Tozzi,Federica

AU - Farmer,Anne

AU - McGuffin,Peter

AU - Strauss,John

AU - Xu,Wei

AU - Kennedy,James L.

AU - Vincent,John B.

AU - Matthews,Keith

AU - Day,Richard

AU - Ferreira,Manuel A.

AU - O'Dushlaine,Colm

AU - Perlis,Roy

AU - Raychaudhuri,Soumya

AU - Ruderfer,Douglas

AU - Lee,Phil H.

AU - Smoller,Jordan W.

AU - Li,Jun

AU - Absher,Devin

AU - Bunney,William E.

AU - Barchas,Jack D.

AU - Schatzberg,Alan F.

AU - Jones,Edward G.

AU - Meng,Fan Guo

AU - Thompson,Robert C.

AU - Watson,Stanley J.

AU - Myers,Richard M.

AU - Akil,Huda

AU - Boehnke,Michael

AU - Chambert,Kim

AU - Moran,Jennifer

AU - Scolnick,Ed

AU - Djurovic,Srdjan

AU - Melle,Ingrid

AU - Morken,Gunnar

AU - Gill,Michael

AU - Morris,Derek

AU - Quinn,Emma

AU - Mühleisen,Thomas W.

AU - Degenhardt,Franziska A.

AU - Mattheisen,Manuel

AU - Schumacher,Johannes

AU - Maier,Wolfgang

AU - Steffens,Michael

AU - Propping,Peter

AU - Noethen,Markus M.

AU - Anjorin,Adebayo

AU - Bass,Nick

AU - Gurling,Hugh

AU - Kandaswamy,Radhika

AU - Lawrence,Jacob

AU - McGhee,Kevin

AU - McIntosh,Andrew

AU - McLean,Alan W.

AU - Muir,Walter J.

AU - Pickard,Benjamin S.

AU - Breen,Gerome

AU - St Clair,David

AU - Caesar,Sian

AU - Gordon-Smith,Katherine

AU - Jones,Lisa

AU - Fraser,Christine

AU - Green,Elaine K.

AU - Grozeva,Detelina

AU - Jones,Ian R.

AU - Kirov,George

AU - Moskvina,Valentina

AU - Nikolov,Ivan

AU - O'Donovan,Michael C.

AU - Owen,Michael J.

AU - Collier,David A.

AU - Elkin,Amanda

AU - Matthews,Keith

AU - Young,Allan H.

AU - Ferrier,I. Nicol

AU - Williamson,Richard

AU - Stefansson,Kari

AU - Stefansson,Hreinn

AU - Porgeirsson,Porgeir

AU - Steinberg,Stacy

AU - Gustafsson,Omar

AU - Bergen,Sarah E.

AU - Nimgaonkar,Vishwajit

AU - Hultman,Christina

AU - Landen,Mikael

AU - Lichtenstein,Paul

AU - Sullivan,Patrick

AU - Schalling,Martin

AU - Osby,Urban

AU - Backlund,Lena

AU - Frisen,Louise

AU - Langstrom,Niklas

AU - Jamain,Stephane

AU - Leboyer,Marion

AU - Etain,Bruno

AU - Bellivier,Frank

AU - Petursson,Hannes

AU - Sigurosson,Engilbert

AU - Mueller-Mysok,Bertram

AU - Lucae,Susanne

AU - Schwarz,Markus

AU - Schofield,Peter R.

AU - Martin,Nick

AU - Montgomery,Grant W.

AU - Lathrop,Mark

AU - Oskarsson,Hogni

AU - Bauer,Michael

AU - Wright,Adam

AU - Mitchell,Philip B.

AU - Hautzinger,Martin

AU - Reif,Andreas

AU - Kelsoe,John R.

AU - Purcell,Shaun M.

AU - Psychiat GWAS Consortium Bipolar D

PY - 2011/10

Y1 - 2011/10

N2 - <p>We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P &lt; 0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 x 10(-7)). An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. We identified a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals. Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. Our replication results imply that increasing sample sizes in bipolar disorder will confirm many additional loci.</p>

AB - <p>We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P &lt; 0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 x 10(-7)). An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. We identified a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals. Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. Our replication results imply that increasing sample sizes in bipolar disorder will confirm many additional loci.</p>

KW - PSYCHIATRIC-DISORDERS

KW - SCHIZOPHRENIA

KW - INDIVIDUALS

KW - CACNA1C

KW - RISK

KW - PSYCHOSIS

KW - GENETICS

KW - ANK3

U2 - 10.1038/ng.943

DO - 10.1038/ng.943

M3 - Article

VL - 43

SP - 977

EP - 983

JO - Nature Genetics

T2 - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -

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