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Low Dose Responses of Bone Marrow to X-Rays In Vivo

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Low Dose Responses of Bone Marrow to X-Rays In Vivo. / Zyuzikov, Nikolay A.; Coates, Philip J.; Lorimore, Sally A.; Wright, Eric G.

Radiobiology and environmental security. ed. / CE Mothersill; V Korogodina; CB Seymour. Dordrecht : Springer, 2012. p. 141-151.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Harvard

Zyuzikov, NA, Coates, PJ, Lorimore, SA & Wright, EG 2012, 'Low Dose Responses of Bone Marrow to X-Rays In Vivo'. in CE Mothersill, V Korogodina & CB Seymour (eds), Radiobiology and environmental security. Springer, Dordrecht, pp. 141-151, NATO Advanced Research Workshop on Radiological Issues Pertaining to Environmental Security and Ecoterrorism, Alushta, Ukraine, 9-14 October., 10.1007/978-94-007-1939-2_13

APA

Zyuzikov, N. A., Coates, P. J., Lorimore, S. A., & Wright, E. G. (2012). Low Dose Responses of Bone Marrow to X-Rays In Vivo. In C. E. Mothersill, V. Korogodina, & C. B. Seymour (Eds.), Radiobiology and environmental security. (pp. 141-151). Dordrecht: Springer. 10.1007/978-94-007-1939-2_13

Vancouver

Zyuzikov NA, Coates PJ, Lorimore SA, Wright EG. Low Dose Responses of Bone Marrow to X-Rays In Vivo. In Mothersill CE, Korogodina V, Seymour CB, editors, Radiobiology and environmental security. Dordrecht: Springer. 2012. p. 141-151. Available from: 10.1007/978-94-007-1939-2_13

Author

Zyuzikov, Nikolay A.; Coates, Philip J.; Lorimore, Sally A.; Wright, Eric G. / Low Dose Responses of Bone Marrow to X-Rays In Vivo.

Radiobiology and environmental security. ed. / CE Mothersill; V Korogodina; CB Seymour. Dordrecht : Springer, 2012. p. 141-151.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bibtex - Download

@inbook{e0ca7c5192bf4bfdb797ec89918863b2,
title = "Low Dose Responses of Bone Marrow to X-Rays In Vivo",
publisher = "Springer",
author = "Zyuzikov, {Nikolay A.} and Coates, {Philip J.} and Lorimore, {Sally A.} and Wright, {Eric G.}",
year = "2012",
doi = "10.1007/978-94-007-1939-2_13",
editor = "CE Mothersill and V Korogodina and CB Seymour",
isbn = "978-94-007-1938-5",
pages = "141-151",
booktitle = "Radiobiology and environmental security",

}

RIS (suitable for import to EndNote) - Download

TY - CHAP

T1 - Low Dose Responses of Bone Marrow to X-Rays In Vivo

A1 - Zyuzikov,Nikolay A.

A1 - Coates,Philip J.

A1 - Lorimore,Sally A.

A1 - Wright,Eric G.

AU - Zyuzikov,Nikolay A.

AU - Coates,Philip J.

AU - Lorimore,Sally A.

AU - Wright,Eric G.

PB - Springer

CY - Dordrecht

PY - 2012

Y1 - 2012

N2 - <p>Radiation risk at low doses is determined by linear extrapolation from high dose epidemiological data. In the last decade many non-targeted effects have been reported which may be relevant to low dose risk determination. To investigate cell responses at such low doses we used bone marrow cells of mice. We have not observed non-targeted effects long- or short-term post irradiation. Exposure below 50-100 mGy provides no evidence of a dose response for apoptotic signaling, bystander effects and low responses for p53 and p21 induction with significant individual variability. There is also no evidence for long-term chromosomal instability in the bone marrow at doses below 1 Gy. The data also demonstrate unexpected thresholds above which dose-dependent damage signaling is observed and the chromosomal instability phenotype is induced. The data are consistent with low dose X-irradiation being less damaging than would be expected from the LNT paradigm.</p>

AB - <p>Radiation risk at low doses is determined by linear extrapolation from high dose epidemiological data. In the last decade many non-targeted effects have been reported which may be relevant to low dose risk determination. To investigate cell responses at such low doses we used bone marrow cells of mice. We have not observed non-targeted effects long- or short-term post irradiation. Exposure below 50-100 mGy provides no evidence of a dose response for apoptotic signaling, bystander effects and low responses for p53 and p21 induction with significant individual variability. There is also no evidence for long-term chromosomal instability in the bone marrow at doses below 1 Gy. The data also demonstrate unexpected thresholds above which dose-dependent damage signaling is observed and the chromosomal instability phenotype is induced. The data are consistent with low dose X-irradiation being less damaging than would be expected from the LNT paradigm.</p>

U2 - 10.1007/978-94-007-1939-2_13

DO - 10.1007/978-94-007-1939-2_13

M1 - Conference contribution

SN - 978-94-007-1938-5

BT - Radiobiology and environmental security

T2 - Radiobiology and environmental security

A2 - Seymour,CB

ED - Seymour,CB

SP - 141

EP - 151

ER -

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