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Making trials matter

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Making trials matter : pragmatic and explanatory trials and the problem of applicability. / Treweek, Shaun; Zwarenstein, Merrick.

In: Trials, Vol. 10, 37, 03.06.2009, p. -.

Research output: Contribution to journalScientific review

Harvard

Treweek, S & Zwarenstein, M 2009, 'Making trials matter: pragmatic and explanatory trials and the problem of applicability' Trials, vol 10, 37, pp. -., 10.1186/1745-6215-10-37

APA

Treweek, S., & Zwarenstein, M. (2009). Making trials matter: pragmatic and explanatory trials and the problem of applicability. Trials, 10, -. [37]. 10.1186/1745-6215-10-37

Vancouver

Treweek S, Zwarenstein M. Making trials matter: pragmatic and explanatory trials and the problem of applicability. Trials. 2009 Jun 3;10:-. 37. Available from: 10.1186/1745-6215-10-37

Author

Treweek, Shaun; Zwarenstein, Merrick / Making trials matter : pragmatic and explanatory trials and the problem of applicability.

In: Trials, Vol. 10, 37, 03.06.2009, p. -.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{349a55950b3140e2aa74dcdfd5ade712,
title = "Making trials matter: pragmatic and explanatory trials and the problem of applicability",
keywords = "Randomised controlled trials",
author = "Shaun Treweek and Merrick Zwarenstein",
year = "2009",
doi = "10.1186/1745-6215-10-37",
volume = "10",
pages = "--",
journal = "Trials",
issn = "1745-6215",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Making trials matter

T2 - pragmatic and explanatory trials and the problem of applicability

A1 - Treweek,Shaun

A1 - Zwarenstein,Merrick

AU - Treweek,Shaun

AU - Zwarenstein,Merrick

PY - 2009/6/3

Y1 - 2009/6/3

N2 - <p>Randomised controlled trials are the best research design for decisions about the effect of different interventions but randomisation does not, of itself, promote the applicability of a trial's results to situations other than the precise one in which the trial was done. While methodologists and trialists have rightly paid great attention to internal validity, much less has been given to applicability.</p><p>This narrative review is aimed at those planning to conduct trials, and those aiming to use the information in them. It is intended to help the former group make their trials more widely useful and to help the latter group make more informed decisions about the wider use of existing trials. We review the differences between the design of most randomised trials (which have an explanatory attitude) and the design of trials more able to inform decision making (which have a pragmatic attitude) and discuss approaches used to assert applicability of trial results.</p><p>If we want evidence from trials to be used in clinical practice and policy, trialists should make every effort to make their trial widely applicable, which means that more trials should be pragmatic in attitude.</p>

AB - <p>Randomised controlled trials are the best research design for decisions about the effect of different interventions but randomisation does not, of itself, promote the applicability of a trial's results to situations other than the precise one in which the trial was done. While methodologists and trialists have rightly paid great attention to internal validity, much less has been given to applicability.</p><p>This narrative review is aimed at those planning to conduct trials, and those aiming to use the information in them. It is intended to help the former group make their trials more widely useful and to help the latter group make more informed decisions about the wider use of existing trials. We review the differences between the design of most randomised trials (which have an explanatory attitude) and the design of trials more able to inform decision making (which have a pragmatic attitude) and discuss approaches used to assert applicability of trial results.</p><p>If we want evidence from trials to be used in clinical practice and policy, trialists should make every effort to make their trial widely applicable, which means that more trials should be pragmatic in attitude.</p>

KW - Randomised controlled trials

U2 - 10.1186/1745-6215-10-37

DO - 10.1186/1745-6215-10-37

M1 - Scientific review

JO - Trials

JF - Trials

SN - 1745-6215

VL - 10

SP - -

ER -

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