Malignant transformation From benign papillomatosis of the external auditory canal

TY - JOUR

T1 - Malignant transformation From benign papillomatosis of the external auditory canal

A1 - Miah,Mohammed S.

A1 - Crawford,Mairi

A1 - White,Sharon J.

A1 - Hussain,Syed Shah Musheer

AU - Miah,Mohammed S.

AU - Crawford,Mairi

AU - White,Sharon J.

AU - Hussain,Syed Shah Musheer

PY - 2012/6

Y1 - 2012/6

N2 - Objective: Report a case of malignant transformation of benign ear canal papillomatosis to malignant squamous cell carcinoma (SCC) of the temporal bone.</p><p>Patients: A 73-year-old with papillomata involving the posterior and inferior walls of the right external auditory canal (EAC), which subsequently transformed into SCC.</p><p>Interventions: Radical mastoidectomy and excision of the tumor and then radical radiotherapy.</p><p>Main Outcome Measures: Loco-regional disease control. Recovery of facial nerve function.</p><p>Results: Approximately 20 months post-treatment, the patient remains disease free. No recovery of facial nerve function.</p><p>Conclusion: Malignant transformation of a benign EAC papilloma to SCC of the temporal bone has not been reported previously. The association of human papillomavirus with temporal bone SCC has been reported in small number of studies with human papillomavirus subtypes 16 and 18 isolated in a high proportion of cases. With the increased availability in genotyping, the question over whether there should be further genetic analysis of benign lesions to assess their susceptibility to malignant transformation has merit.</p>

AB - Objective: Report a case of malignant transformation of benign ear canal papillomatosis to malignant squamous cell carcinoma (SCC) of the temporal bone.</p><p>Patients: A 73-year-old with papillomata involving the posterior and inferior walls of the right external auditory canal (EAC), which subsequently transformed into SCC.</p><p>Interventions: Radical mastoidectomy and excision of the tumor and then radical radiotherapy.</p><p>Main Outcome Measures: Loco-regional disease control. Recovery of facial nerve function.</p><p>Results: Approximately 20 months post-treatment, the patient remains disease free. No recovery of facial nerve function.</p><p>Conclusion: Malignant transformation of a benign EAC papilloma to SCC of the temporal bone has not been reported previously. The association of human papillomavirus with temporal bone SCC has been reported in small number of studies with human papillomavirus subtypes 16 and 18 isolated in a high proportion of cases. With the increased availability in genotyping, the question over whether there should be further genetic analysis of benign lesions to assess their susceptibility to malignant transformation has merit.</p>

U2 - 10.1097/MAO.0b013e31824b76d3

DO - 10.1097/MAO.0b013e31824b76d3

M1 - Article

JO - Otology & Neurotology

JF - Otology & Neurotology

SN - 1531-7129

IS - 4

VL - 33

SP - 643

EP - 647

ER -