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Mechanisms for ATP-dependent chromatin remodelling

Mechanisms for ATP-dependent chromatin remodelling: the means to the end

Research output: Contribution to journalScientific review

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Authors

  • Andrew Flaus
  • Tom Owen-Hughes

Research units

Info

Original languageEnglish
Pages3579-3595
Number of pages17
JournalFEBS Journal
Journal publication dateOct 2011
Volume278
Issue19
DOIs
StatePublished

Abstract

Chromatin remodelling is the ATP-dependent change in nucleosome organisation driven by Snf2 family ATPases. The biochemistry of this process depends on the behaviours of ATP-dependent motor proteins and their dynamic nucleosome substrates, which brings significant technical and conceptual challenges. Steady progress has been made in characterising the polypeptides of which these enzymes are comprised. Divergence in the sequences of different subfamilies of Snf2-related proteins suggests that the motors are adapted for different functions. Recently, structural insights have suggested that the Snf2 ATPase acts as a context-sensitive DNA translocase. This may have arisen as a means to enable efficient access to DNA in the high density of the eukaryotic nucleus. How the enzymes engage nucleosomes and how the network of noncovalent interactions within the nucleosome respond to the force applied remains unclear, and it remains prudent to recognise the potential for both DNA distortions and dynamics within the underlying histone octamer structure.

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