Discovery - University of Dundee - Online Publications

Library & Learning Centre

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

Standard

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer. / Lightfoot, Tracy J.; Barrett, Jennifer H.; Bishop, Timothy; Northwood, Emma L.; Smith, Gillian; Wilkie, Murray J. V.; Steele, Robert J. C.; Carey, Francis A.; Key, Tim J.; Wolf, Roland; Forman, David.

In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 17, No. 9, 09.2008, p. 2421-2430.

Research output: Contribution to journalArticle

Harvard

Lightfoot, TJ, Barrett, JH, Bishop, T, Northwood, EL, Smith, G, Wilkie, MJV, Steele, RJC, Carey, FA, Key, TJ, Wolf, R & Forman, D 2008, 'Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer' Cancer Epidemiology, Biomarkers & Prevention, vol 17, no. 9, pp. 2421-2430., 10.1158/1055-9965.EPI-08-0058

APA

Lightfoot, T. J., Barrett, J. H., Bishop, T., Northwood, E. L., Smith, G., Wilkie, M. J. V., ... Forman, D. (2008). Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer. Cancer Epidemiology, Biomarkers & Prevention, 17(9), 2421-2430. 10.1158/1055-9965.EPI-08-0058

Vancouver

Lightfoot TJ, Barrett JH, Bishop T, Northwood EL, Smith G, Wilkie MJV et al. Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer. Cancer Epidemiology, Biomarkers & Prevention. 2008 Sep;17(9):2421-2430. Available from: 10.1158/1055-9965.EPI-08-0058

Author

Lightfoot, Tracy J.; Barrett, Jennifer H.; Bishop, Timothy; Northwood, Emma L.; Smith, Gillian; Wilkie, Murray J. V.; Steele, Robert J. C.; Carey, Francis A.; Key, Tim J.; Wolf, Roland; Forman, David / Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.

In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 17, No. 9, 09.2008, p. 2421-2430.

Research output: Contribution to journalArticle

Bibtex - Download

@article{bff0db51522c4cd4b9e2ecd467e4b580,
title = "Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer",
keywords = "C677T MTHFR polymorphism, Methylenetetrahydrofolate reductase, A1298C polymorphisms, Alcohol intake, Colon cancer, Hyperplastic polyps, Vascular disease, Common mutation, Plasma folate, United States",
author = "Lightfoot, {Tracy J.} and Barrett, {Jennifer H.} and Timothy Bishop and Northwood, {Emma L.} and Gillian Smith and Wilkie, {Murray J. V.} and Steele, {Robert J. C.} and Carey, {Francis A.} and Key, {Tim J.} and Roland Wolf and David Forman",
year = "2008",
doi = "10.1158/1055-9965.EPI-08-0058",
volume = "17",
number = "9",
pages = "2421--2430",
journal = "Cancer Epidemiology, Biomarkers & Prevention",
issn = "1055-9965",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

A1 - Lightfoot,Tracy J.

A1 - Barrett,Jennifer H.

A1 - Bishop,Timothy

A1 - Northwood,Emma L.

A1 - Smith,Gillian

A1 - Wilkie,Murray J. V.

A1 - Steele,Robert J. C.

A1 - Carey,Francis A.

A1 - Key,Tim J.

A1 - Wolf,Roland

A1 - Forman,David

AU - Lightfoot,Tracy J.

AU - Barrett,Jennifer H.

AU - Bishop,Timothy

AU - Northwood,Emma L.

AU - Smith,Gillian

AU - Wilkie,Murray J. V.

AU - Steele,Robert J. C.

AU - Carey,Francis A.

AU - Key,Tim J.

AU - Wolf,Roland

AU - Forman,David

PY - 2008/9

Y1 - 2008/9

N2 - <p>Epidemiologic evidence suggests a role for folate, a critical component of the 1-carbon cycle, in colorectal adenoma and cancer pathogenesis. Low folate levels, along with genetic polymorphisms in key enzymes such as methylene tetrahydrofolate reductase (MTHFR), can cause DNA hypomethylation and aberrant CpG methylation, which have been associated with colorectal tumor development. We investigated self-reported folate and alcohol intake alongside possible modifying effects of MTHFR 677 C &gt; T and 1298 A &gt; C polymorphisms in UK case-control studies of colorectal adenoma (317 cases, 296 controls) and cancer (500 cases, 742 controls). A significant association between MTHFR 1298 and colorectal cancer risk was observed [odds ratio, 1.57; 95% confidence interval (95% CI), 1.05-2.37], which was more pronounced in males (odds ratio, 3.02; 95% CI, 1.63-5.62). Although we found no association between MTHFR 677 and colorectal cancer, when data were stratified by sex, an increased risk was seen in females (odds ratio, 1.96; 95% CI, 1.11-3.46) but not in males. High folate intake was associated with a decreased risk for colorectal adenoma (odds ratio, 0.47; 95% CI, 0.30-0.73; P-trend, &lt; 0.001), which was modified by MTHFR 1298 genotype (P-interaction 0.006). However, we found no evidence to support the hypothesis that a high-folate diet protects against colorectal cancer development. Consistent with previous studies, high alcohol intake (&gt;= 14 U/wk) was associated with a significantly increased cancer risk (odds ratio, 2.57; 95% CI, 1.81-3.64). Our data suggest that dietary folate intake may be an important determinant for premalignant colorectal disease development but not colorectal cancer, an association that is modified by MTHFR genotype.</p>

AB - <p>Epidemiologic evidence suggests a role for folate, a critical component of the 1-carbon cycle, in colorectal adenoma and cancer pathogenesis. Low folate levels, along with genetic polymorphisms in key enzymes such as methylene tetrahydrofolate reductase (MTHFR), can cause DNA hypomethylation and aberrant CpG methylation, which have been associated with colorectal tumor development. We investigated self-reported folate and alcohol intake alongside possible modifying effects of MTHFR 677 C &gt; T and 1298 A &gt; C polymorphisms in UK case-control studies of colorectal adenoma (317 cases, 296 controls) and cancer (500 cases, 742 controls). A significant association between MTHFR 1298 and colorectal cancer risk was observed [odds ratio, 1.57; 95% confidence interval (95% CI), 1.05-2.37], which was more pronounced in males (odds ratio, 3.02; 95% CI, 1.63-5.62). Although we found no association between MTHFR 677 and colorectal cancer, when data were stratified by sex, an increased risk was seen in females (odds ratio, 1.96; 95% CI, 1.11-3.46) but not in males. High folate intake was associated with a decreased risk for colorectal adenoma (odds ratio, 0.47; 95% CI, 0.30-0.73; P-trend, &lt; 0.001), which was modified by MTHFR 1298 genotype (P-interaction 0.006). However, we found no evidence to support the hypothesis that a high-folate diet protects against colorectal cancer development. Consistent with previous studies, high alcohol intake (&gt;= 14 U/wk) was associated with a significantly increased cancer risk (odds ratio, 2.57; 95% CI, 1.81-3.64). Our data suggest that dietary folate intake may be an important determinant for premalignant colorectal disease development but not colorectal cancer, an association that is modified by MTHFR genotype.</p>

KW - C677T MTHFR polymorphism

KW - Methylenetetrahydrofolate reductase

KW - A1298C polymorphisms

KW - Alcohol intake

KW - Colon cancer

KW - Hyperplastic polyps

KW - Vascular disease

KW - Common mutation

KW - Plasma folate

KW - United States

U2 - 10.1158/1055-9965.EPI-08-0058

DO - 10.1158/1055-9965.EPI-08-0058

M1 - Article

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 9

VL - 17

SP - 2421

EP - 2430

ER -

Documents

Library & Learning Centre

Contact | Accessibility | Policy