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Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot

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Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot. / Duce, Suzanne; Madrigal, Londale; Schmidt, Katy; Cunningham, Craig; Liu, Guoqing; Barker, Simon; Tennant, Gordon; Tickle, Cheryll; Chudek, Sandy; Miedzybrodzka, Zosia.

In: Journal of Anatomy, Vol. 216, No. 1, 01.2010, p. 108-120.

Research output: Contribution to journalArticle

Harvard

Duce, S, Madrigal, L, Schmidt, K, Cunningham, C, Liu, G, Barker, S, Tennant, G, Tickle, C, Chudek, S & Miedzybrodzka, Z 2010, 'Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot' Journal of Anatomy, vol 216, no. 1, pp. 108-120., 10.1111/j.1469-7580.2009.01163.x

APA

Duce, S., Madrigal, L., Schmidt, K., Cunningham, C., Liu, G., Barker, S., ... Miedzybrodzka, Z. (2010). Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot. Journal of Anatomy, 216(1), 108-120. 10.1111/j.1469-7580.2009.01163.x

Vancouver

Duce S, Madrigal L, Schmidt K, Cunningham C, Liu G, Barker S et al. Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot. Journal of Anatomy. 2010 Jan;216(1):108-120. Available from: 10.1111/j.1469-7580.2009.01163.x

Author

Duce, Suzanne; Madrigal, Londale; Schmidt, Katy; Cunningham, Craig; Liu, Guoqing; Barker, Simon; Tennant, Gordon; Tickle, Cheryll; Chudek, Sandy; Miedzybrodzka, Zosia / Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot.

In: Journal of Anatomy, Vol. 216, No. 1, 01.2010, p. 108-120.

Research output: Contribution to journalArticle

Bibtex - Download

@article{f228006b9f32444f884a8bda119ea4c8,
title = "Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot",
author = "Suzanne Duce and Londale Madrigal and Katy Schmidt and Craig Cunningham and Guoqing Liu and Simon Barker and Gordon Tennant and Cheryll Tickle and Sandy Chudek and Zosia Miedzybrodzka",
year = "2010",
doi = "10.1111/j.1469-7580.2009.01163.x",
volume = "216",
number = "1",
pages = "108--120",
journal = "Journal of Anatomy",
issn = "0021-8782",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot

A1 - Duce,Suzanne

A1 - Madrigal,Londale

A1 - Schmidt,Katy

A1 - Cunningham,Craig

A1 - Liu,Guoqing

A1 - Barker,Simon

A1 - Tennant,Gordon

A1 - Tickle,Cheryll

A1 - Chudek,Sandy

A1 - Miedzybrodzka,Zosia

AU - Duce,Suzanne

AU - Madrigal,Londale

AU - Schmidt,Katy

AU - Cunningham,Craig

AU - Liu,Guoqing

AU - Barker,Simon

AU - Tennant,Gordon

AU - Tickle,Cheryll

AU - Chudek,Sandy

AU - Miedzybrodzka,Zosia

PY - 2010/1

Y1 - 2010/1

N2 - Gross similarities between the external appearance of the hind limbs of the peroneal muscle atrophy (pma) mouse mutant and congenital talipes equinovarus (CTEV), a human disorder historically referred to as 'clubfoot', suggested that this mutant could be a useful model. We used micro-magnetic resonance imaging to visualize the detailed anatomy of the hind limb defect in mutant pma mice and performed 3D comparisons between mutant and wild-type hind limbs. We found that the pma foot demonstrates supination (i.e. adduction and inversion of the mid foot and fore foot together with plantar flexion of the ankle and toes) and that the tibiale and distal tarsals display 3D abnormalities in positioning. The size and shape of the tibia, fibula, tarsal and metatarsal bones are similar to the wild-type. Hypoplasia of the muscles in the antero-lateral (peroneal) compartment was also demonstrated. The resemblance of these features to those seen in CTEV suggests that the pma mouse is a possibly useful model for the human condition. To understand how the observed deformities in the pma mouse hind foot arise during embryonic development, we followed the process of foot rotation in both wild-type and pma mutant mice. Rotation of the hind foot in mouse embryos of wild-type strains (CD-1 and C57/Black) occurs from embryonic day 14.5 onwards with rotation in C57/Black taking longer. In embryos from both strains, rotation of the right hind foot more commonly precedes rotation of the left. In pma mutants, the initiation of rotation is often delayed and rotation is slower and does not reach completion. If the usefulness of the pma mutant as a model is confirmed, then these findings on pma mouse embryos, when extrapolated to humans, would support a long-standing hypothesis that CTEV is due to the failure of completion of the normal process of rotation and angulation, historically known as the 'arrested development hypothesis'. © 2009 The Authors. Journal compilation © 2009 Anatomical Society of Great Britain and Ireland.

AB - Gross similarities between the external appearance of the hind limbs of the peroneal muscle atrophy (pma) mouse mutant and congenital talipes equinovarus (CTEV), a human disorder historically referred to as 'clubfoot', suggested that this mutant could be a useful model. We used micro-magnetic resonance imaging to visualize the detailed anatomy of the hind limb defect in mutant pma mice and performed 3D comparisons between mutant and wild-type hind limbs. We found that the pma foot demonstrates supination (i.e. adduction and inversion of the mid foot and fore foot together with plantar flexion of the ankle and toes) and that the tibiale and distal tarsals display 3D abnormalities in positioning. The size and shape of the tibia, fibula, tarsal and metatarsal bones are similar to the wild-type. Hypoplasia of the muscles in the antero-lateral (peroneal) compartment was also demonstrated. The resemblance of these features to those seen in CTEV suggests that the pma mouse is a possibly useful model for the human condition. To understand how the observed deformities in the pma mouse hind foot arise during embryonic development, we followed the process of foot rotation in both wild-type and pma mutant mice. Rotation of the hind foot in mouse embryos of wild-type strains (CD-1 and C57/Black) occurs from embryonic day 14.5 onwards with rotation in C57/Black taking longer. In embryos from both strains, rotation of the right hind foot more commonly precedes rotation of the left. In pma mutants, the initiation of rotation is often delayed and rotation is slower and does not reach completion. If the usefulness of the pma mutant as a model is confirmed, then these findings on pma mouse embryos, when extrapolated to humans, would support a long-standing hypothesis that CTEV is due to the failure of completion of the normal process of rotation and angulation, historically known as the 'arrested development hypothesis'. © 2009 The Authors. Journal compilation © 2009 Anatomical Society of Great Britain and Ireland.

UR - http://www.scopus.com/inward/record.url?scp=73149115716&partnerID=8YFLogxK

U2 - 10.1111/j.1469-7580.2009.01163.x

DO - 10.1111/j.1469-7580.2009.01163.x

M1 - Article

JO - Journal of Anatomy

JF - Journal of Anatomy

SN - 0021-8782

IS - 1

VL - 216

SP - 108

EP - 120

ER -

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