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Models of Dementia: an introductory overview

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Models of Dementia: an introductory overview. / Graham, Lindsay; Sutherland, Calum.

In: Biochemical Society Transactions, Vol. 39, 08.2011, p. 851-856.

Research output: Contribution to journalArticle

Harvard

Graham, L & Sutherland, C 2011, 'Models of Dementia: an introductory overview' Biochemical Society Transactions, vol 39, pp. 851-856.

APA

Graham, L., & Sutherland, C. (2011). Models of Dementia: an introductory overview. Biochemical Society Transactions, 39, 851-856doi: 10.1042/BST0390851

Vancouver

Graham L, Sutherland C. Models of Dementia: an introductory overview. Biochemical Society Transactions. 2011 Aug;39:851-856.

Author

Graham, Lindsay; Sutherland, Calum / Models of Dementia: an introductory overview.

In: Biochemical Society Transactions, Vol. 39, 08.2011, p. 851-856.

Research output: Contribution to journalArticle

Bibtex - Download

@article{a0636bee89de480481812e5f8db1a3da,
title = "Models of Dementia: an introductory overview",
author = "Lindsay Graham and Calum Sutherland",
year = "2011",
volume = "39",
pages = "851--856",
journal = "Biochemical Society Transactions",
issn = "0300-5127",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Models of Dementia: an introductory overview

A1 - Graham,Lindsay

A1 - Sutherland,Calum

AU - Graham,Lindsay

AU - Sutherland,Calum

PY - 2011/8

Y1 - 2011/8

N2 - <p>The analysis of the molecular development of AD (Alzheimer's disease) is technically challenging, due to the chronic nature of the disease, the lack of early and definitive clinical diagnosis, and the fact that the abnormal molecular pathology occurs in the brain. Therefore appropriate animal models of AD are essential if we are to dissect the processes leading to molecular pathology, and ultimately to test the efficacy of potential therapies before clinical studies. Unfortunately, there is controversy over the benefits of the available models, the only consensus of opinion being that no perfect model currently exists. The investigation of animal models is extremely costly and time-consuming, therefore researchers tend to focus on one or two models. For scientists entering the AD research field, it can be difficult to identify the most appropriate model for their needs. Therefore the Models of Dementia: the Good, the Bad and the Future Biochemical Society Focused Meeting provided a platform for discussion and debate on the use and limitations of current models, the most appropriate methods for their characterization and identification of the most pressing needs of the field in general.</p>

AB - <p>The analysis of the molecular development of AD (Alzheimer's disease) is technically challenging, due to the chronic nature of the disease, the lack of early and definitive clinical diagnosis, and the fact that the abnormal molecular pathology occurs in the brain. Therefore appropriate animal models of AD are essential if we are to dissect the processes leading to molecular pathology, and ultimately to test the efficacy of potential therapies before clinical studies. Unfortunately, there is controversy over the benefits of the available models, the only consensus of opinion being that no perfect model currently exists. The investigation of animal models is extremely costly and time-consuming, therefore researchers tend to focus on one or two models. For scientists entering the AD research field, it can be difficult to identify the most appropriate model for their needs. Therefore the Models of Dementia: the Good, the Bad and the Future Biochemical Society Focused Meeting provided a platform for discussion and debate on the use and limitations of current models, the most appropriate methods for their characterization and identification of the most pressing needs of the field in general.</p>

KW - Alzheimer's disease

KW - amyloid beta-peptide (A beta)

KW - dementia

KW - disease model

KW - molecular pathology

KW - AMYLOID PRECURSOR PROTEIN

KW - TRANSGENIC MOUSE MODEL

KW - LONG-TERM POTENTIATION

KW - AGE-RELATED IMPAIRMENT

KW - A-BETA-DEPOSITION

KW - ALZHEIMERS-DISEASE

KW - SYNAPTIC-TRANSMISSION

KW - IN-VIVO

KW - MICE

KW - PATHOLOGY

U2 - 10.1042/BST0390851

DO - 10.1042/BST0390851

M1 - Article

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

VL - 39

SP - 851

EP - 856

ER -

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