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Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration

Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration

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Authors

  • Alejandra Catenaccio
  • Maica Llavero Hurtado
  • Paula Diaz
  • Douglas J. Lamont
  • Thomas M. Wishart
  • Felipe A. Court (Lead / Corresponding author)

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Original languageEnglish
Article numbere3166
Number of pages14
JournalCell Death and Disease
Volume8
Issue number11
DOIs
StatePublished - 9 Nov 2017

Abstract

Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction.

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    Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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