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Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas

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Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas. / Valentine, Ronan M.; Brown, C. Tom A.; Moseley, Harry; Ibbotson, Sally; Wood, Kenny.

In: Journal of Biomedical Optics, Vol. 16, No. 4, 048002, 04.2011, p. -.

Research output: Contribution to journalArticle

Harvard

Valentine, RM, Brown, CTA, Moseley, H, Ibbotson, S & Wood, K 2011, 'Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas' Journal of Biomedical Optics, vol 16, no. 4, 048002, pp. -., 10.1117/1.3562540

APA

Valentine, R. M., Brown, C. T. A., Moseley, H., Ibbotson, S., & Wood, K. (2011). Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas. Journal of Biomedical Optics, 16(4), -. [048002]. 10.1117/1.3562540

Vancouver

Valentine RM, Brown CTA, Moseley H, Ibbotson S, Wood K. Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas. Journal of Biomedical Optics. 2011 Apr;16(4):-. 048002. Available from: 10.1117/1.3562540

Author

Valentine, Ronan M.; Brown, C. Tom A.; Moseley, Harry; Ibbotson, Sally; Wood, Kenny / Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas.

In: Journal of Biomedical Optics, Vol. 16, No. 4, 048002, 04.2011, p. -.

Research output: Contribution to journalArticle

Bibtex - Download

@article{27885f09d4f44b398d00497a8bdc2781,
title = "Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas",
keywords = "protoporphyrin IX fluorescence, photodynamic therapy, photobleaching, singlet oxygen, photodynamic doses, superficial basal cell carcinoma, Monte Carlo simulations, AXISYMMETRICAL CIRCUMSTELLAR ENVELOPES, MULTIPLE-SCATTERING, LIGHT DISTRIBUTIONS, THOMSON SCATTERING, OPTICAL-PROPERTIES, SKIN-CANCER, DOSIMETRY, TISSUE, POLARIZATION, PORPHYRINS",
author = "Valentine, {Ronan M.} and Brown, {C. Tom A.} and Harry Moseley and Sally Ibbotson and Kenny Wood",
year = "2011",
doi = "10.1117/1.3562540",
volume = "16",
number = "4",
pages = "--",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas

A1 - Valentine,Ronan M.

A1 - Brown,C. Tom A.

A1 - Moseley,Harry

A1 - Ibbotson,Sally

A1 - Wood,Kenny

AU - Valentine,Ronan M.

AU - Brown,C. Tom A.

AU - Moseley,Harry

AU - Ibbotson,Sally

AU - Wood,Kenny

PY - 2011/4

Y1 - 2011/4

N2 - <p>We present protoporphyrin IX (PpIX) fluorescence measurements acquired from patients presenting with superficial basal cell carcinoma during photodynamic therapy (PDT) treatment, facilitating in vivo photobleaching to be monitored. Monte Carlo (MC) simulations, taking into account photobleaching, are performed on a three-dimensional cube grid, which represents the treatment geometry. Consequently, it is possible to determine the spatial and temporal changes to the origin of collected fluorescence and generated singlet oxygen. From our clinical results, an in vivo photobleaching dose constant, beta of 5-aminolaevulinic acid-induced PpIX fluorescence is found to be 14 +/- 1 J/cm(2). Results from our MC simulations suggest that an increase from our typical administered treatment light dose of 75-150 J/cm(2) could increase the effective PDT treatment initially achieved at a depth of 2.7-3.3 mm in the tumor, respectively. Moreover, this increase reduces the surface PpIX fluorescence from 0.00012 to 0.000003 of the maximum value recorded before treatment. The recommendation of administrating a larger light dose, which advocates an increase in the treatment time after surface PpIX fluorescence has diminished, remains valid for different sets of optical properties and therefore should have a beneficial outcome on the total treatment effect. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3562540]</p>

AB - <p>We present protoporphyrin IX (PpIX) fluorescence measurements acquired from patients presenting with superficial basal cell carcinoma during photodynamic therapy (PDT) treatment, facilitating in vivo photobleaching to be monitored. Monte Carlo (MC) simulations, taking into account photobleaching, are performed on a three-dimensional cube grid, which represents the treatment geometry. Consequently, it is possible to determine the spatial and temporal changes to the origin of collected fluorescence and generated singlet oxygen. From our clinical results, an in vivo photobleaching dose constant, beta of 5-aminolaevulinic acid-induced PpIX fluorescence is found to be 14 +/- 1 J/cm(2). Results from our MC simulations suggest that an increase from our typical administered treatment light dose of 75-150 J/cm(2) could increase the effective PDT treatment initially achieved at a depth of 2.7-3.3 mm in the tumor, respectively. Moreover, this increase reduces the surface PpIX fluorescence from 0.00012 to 0.000003 of the maximum value recorded before treatment. The recommendation of administrating a larger light dose, which advocates an increase in the treatment time after surface PpIX fluorescence has diminished, remains valid for different sets of optical properties and therefore should have a beneficial outcome on the total treatment effect. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3562540]</p>

KW - protoporphyrin IX fluorescence

KW - photodynamic therapy

KW - photobleaching

KW - singlet oxygen

KW - photodynamic doses

KW - superficial basal cell carcinoma

KW - Monte Carlo simulations

KW - AXISYMMETRICAL CIRCUMSTELLAR ENVELOPES

KW - MULTIPLE-SCATTERING

KW - LIGHT DISTRIBUTIONS

KW - THOMSON SCATTERING

KW - OPTICAL-PROPERTIES

KW - SKIN-CANCER

KW - DOSIMETRY

KW - TISSUE

KW - POLARIZATION

KW - PORPHYRINS

U2 - 10.1117/1.3562540

DO - 10.1117/1.3562540

M1 - Article

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 4

VL - 16

SP - -

ER -

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