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MSK1 regulates homeostatic and experience-dependent synaptic plasticity

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MSK1 regulates homeostatic and experience-dependent synaptic plasticity. / Corrêa, Sonia A. L. ; Hunter, Christopher J.; Palygin, Oleg; Wauters, S.C.; Martin, Kirsty J.; McKenzie, Colin; McKelvey, Kim; Morris, Richard G. M. ; Pankratov, Yuriy; Arthur, J.Simon C.; Frenguelli, BrunoG.

In: Journal of Neuroscience, Vol. 32, No. 38, 2012, p. 13039-13051.

Research output: Contribution to journalArticle

Harvard

Corrêa, SAL, Hunter, CJ, Palygin, O, Wauters, SC, Martin, KJ, McKenzie, C, McKelvey, K, Morris, RGM, Pankratov, Y, Arthur, JSC & Frenguelli, B 2012, 'MSK1 regulates homeostatic and experience-dependent synaptic plasticity' Journal of Neuroscience, vol 32, no. 38, pp. 13039-13051., 10.1523/JNEUROSCI.0930-12.2012

APA

Corrêa, S. A. L., Hunter, C. J., Palygin, O., Wauters, S. C., Martin, K. J., McKenzie, C., ... Frenguelli, B. (2012). MSK1 regulates homeostatic and experience-dependent synaptic plasticity. Journal of Neuroscience, 32(38), 13039-13051. 10.1523/JNEUROSCI.0930-12.2012

Vancouver

Corrêa SAL, Hunter CJ, Palygin O, Wauters SC, Martin KJ, McKenzie C et al. MSK1 regulates homeostatic and experience-dependent synaptic plasticity. Journal of Neuroscience. 2012;32(38):13039-13051. Available from: 10.1523/JNEUROSCI.0930-12.2012

Author

Corrêa, Sonia A. L. ; Hunter, Christopher J.; Palygin, Oleg; Wauters, S.C.; Martin, Kirsty J.; McKenzie, Colin; McKelvey, Kim; Morris, Richard G. M. ; Pankratov, Yuriy; Arthur, J.Simon C.; Frenguelli, BrunoG. / MSK1 regulates homeostatic and experience-dependent synaptic plasticity.

In: Journal of Neuroscience, Vol. 32, No. 38, 2012, p. 13039-13051.

Research output: Contribution to journalArticle

Bibtex - Download

@article{1ebd7a961c6e4d06b011bfa419e274a1,
title = "MSK1 regulates homeostatic and experience-dependent synaptic plasticity",
author = "Corrêa, {Sonia A. L.} and Hunter, {Christopher J.} and Oleg Palygin and S.C. Wauters and Martin, {Kirsty J.} and Colin McKenzie and Kim McKelvey and Morris, {Richard G. M.} and Yuriy Pankratov and Arthur, {J.Simon C.} and BrunoG. Frenguelli",
year = "2012",
doi = "10.1523/JNEUROSCI.0930-12.2012",
volume = "32",
number = "38",
pages = "13039--13051",
journal = "Journal of Neuroscience",
issn = "0270-6474",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - MSK1 regulates homeostatic and experience-dependent synaptic plasticity

A1 - Corrêa,Sonia A. L.

A1 - Hunter,Christopher J.

A1 - Palygin,Oleg

A1 - Wauters,S.C.

A1 - Martin,Kirsty J.

A1 - McKenzie,Colin

A1 - McKelvey,Kim

A1 - Morris,Richard G. M.

A1 - Pankratov,Yuriy

A1 - Arthur,J.Simon C.

A1 - Frenguelli,BrunoG.

AU - Corrêa,Sonia A. L.

AU - Hunter,Christopher J.

AU - Palygin,Oleg

AU - Wauters,S.C.

AU - Martin,Kirsty J.

AU - McKenzie,Colin

AU - McKelvey,Kim

AU - Morris,Richard G. M.

AU - Pankratov,Yuriy

AU - Arthur,J.Simon C.

AU - Frenguelli,BrunoG.

PY - 2012

Y1 - 2012

N2 - The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response to environmental influences, the cellular and molecular mechanisms underlying synaptic adaptation are far from clear. Brain-derived neurotrophic factor (BDNF) is a prime initiator of structural and functional synaptic adaptation. However, the signaling cascade activated by BDNF to initiate these adaptive changes has not been elucidated. We have previously shown that BDNF activates mitogen- and stress-activated kinase 1 (MSK1), which regulates gene transcription via the phosphorylation of both CREB and histone H3. Using mice with a kinase-dead knock-in mutation of MSK1, we now show that MSK1 is necessary for the upregulation of synaptic strength in response to environmental enrichment in vivo. Furthermore, neurons from MSK1 kinase-dead mice failed to show scaling of synaptic transmission in response to activity deprivation in vitro, a deficit that could be rescued by reintroduction of wild-type MSK1. We also show that MSK1 forms part of a BDNF-and MAPK-dependent signaling cascade required for homeostatic synaptic scaling, which likely resides in the ability of MSK1 to regulate cell surface GluA1 expression via the induction of Arc/Arg3.1. These results demonstrate that MSK1 is an integral part of a signaling pathway that underlies the adaptive response to synaptic and environmental experience. MSK1 may thus act as a key homeostat in the activity- and experience-dependent regulation of synaptic strength. © 2012 the authors.

AB - The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response to environmental influences, the cellular and molecular mechanisms underlying synaptic adaptation are far from clear. Brain-derived neurotrophic factor (BDNF) is a prime initiator of structural and functional synaptic adaptation. However, the signaling cascade activated by BDNF to initiate these adaptive changes has not been elucidated. We have previously shown that BDNF activates mitogen- and stress-activated kinase 1 (MSK1), which regulates gene transcription via the phosphorylation of both CREB and histone H3. Using mice with a kinase-dead knock-in mutation of MSK1, we now show that MSK1 is necessary for the upregulation of synaptic strength in response to environmental enrichment in vivo. Furthermore, neurons from MSK1 kinase-dead mice failed to show scaling of synaptic transmission in response to activity deprivation in vitro, a deficit that could be rescued by reintroduction of wild-type MSK1. We also show that MSK1 forms part of a BDNF-and MAPK-dependent signaling cascade required for homeostatic synaptic scaling, which likely resides in the ability of MSK1 to regulate cell surface GluA1 expression via the induction of Arc/Arg3.1. These results demonstrate that MSK1 is an integral part of a signaling pathway that underlies the adaptive response to synaptic and environmental experience. MSK1 may thus act as a key homeostat in the activity- and experience-dependent regulation of synaptic strength. © 2012 the authors.

UR - http://www.scopus.com/inward/record.url?scp=84866432385&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.0930-12.2012

DO - 10.1523/JNEUROSCI.0930-12.2012

M1 - Article

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 38

VL - 32

SP - 13039

EP - 13051

ER -

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