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Mucosal biofilm communities in the human intestinal tract

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Mucosal biofilm communities in the human intestinal tract. / Macfarlane, Sandra; Bahrami, Bahram; Macfarlane, George T.

Advances in applied microbiology. ed. / Allen I. Laskin; Sima Sariaslani; Geoffrey M. Gadd. Vol. 75 San Diego : Academic Press, 2011. p. 111-143.

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Harvard

Macfarlane, S, Bahrami, B & Macfarlane, GT 2011, 'Mucosal biofilm communities in the human intestinal tract'. in AI Laskin, S Sariaslani & GM Gadd (eds), Advances in applied microbiology. vol. 75, Academic Press, San Diego, pp. 111-143.

APA

Macfarlane, S., Bahrami, B., & Macfarlane, G. T. (2011). Mucosal biofilm communities in the human intestinal tract. In Laskin, A. I., Sariaslani, S., & Gadd, G. M. (Eds.), Advances in applied microbiology. (pp. 111-143). San Diego: Academic Press. doi: 10.1016/B978-0-12-387046-9.00005-0

Vancouver

Macfarlane S, Bahrami B, Macfarlane GT. Mucosal biofilm communities in the human intestinal tract. In Laskin AI, Sariaslani S, Gadd GM, editors, Advances in applied microbiology. San Diego: Academic Press. 2011. p. 111-143.

Author

Macfarlane, Sandra; Bahrami, Bahram; Macfarlane, George T. / Mucosal biofilm communities in the human intestinal tract.

Advances in applied microbiology. ed. / Allen I. Laskin; Sima Sariaslani; Geoffrey M. Gadd. Vol. 75 San Diego : Academic Press, 2011. p. 111-143.

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Bibtex - Download

@inbook{36504453b49d4e76ac69e8b26dcb9c12,
title = "Mucosal biofilm communities in the human intestinal tract",
publisher = "Academic Press",
author = "Sandra Macfarlane and Bahram Bahrami and Macfarlane, {George T.}",
year = "2011",
editor = "Laskin, {Allen I.} and Sima Sariaslani and Gadd, {Geoffrey M.}",
volume = "75",
isbn = "9780123870469",
pages = "111-143",
booktitle = "Advances in applied microbiology",

}

RIS (suitable for import to EndNote) - Download

TY - CHAP

T1 - Mucosal biofilm communities in the human intestinal tract

A1 - Macfarlane,Sandra

A1 - Bahrami,Bahram

A1 - Macfarlane,George T.

AU - Macfarlane,Sandra

AU - Bahrami,Bahram

AU - Macfarlane,George T.

PB - Academic Press

CY - San Diego

PY - 2011

Y1 - 2011

N2 - <p>Complex and highly variable site-dependent bacterial ecosystems exist throughout the length of the human gastrointestinal tract. Until relatively recently, the majority of our information on intestinal microbiotas has come from studies on feces, or from aspirates taken from the upper gut. However, there is evidence showing that mucosal bacteria growing in biofilms on surfaces lining the gut differ from luminal populations, and that due to their proximity to the epithelial surface, these organisms may be important in modulating the host's immune system and contributing to some chronic inflammatory diseases. Over the past decade, increasing interest in mucosal bacteria, coupled with advances in molecular approaches for assessing microbial diversity, has begun to provide some insight into the complexity of these mucosa-associated communities. In gastrointestinal conditions such as inflammatory bowel diseases (ulcerative colitis, Crohn's disease), it has been shown that a dysbiosis exists in microbial community structure, and that there is a reduction in putatively protective mucosal organisms such as bifidobacteria. Therefore, manipulation of mucosal communities may be beneficial in restoring normal functionality in the gut, thereby improving the immune status and general health of the host. Biofilm structure and function has been studied intensively in the oral cavity, and as a consequence, mucosal communities in the mouth will not be covered in this chapter. This review addresses our current knowledge of mucosal populations in the gastrointestinal tract, changes that can occur in community structure in disease, and therapeutic modulation of biofilm composition by antibiotics, prebiotics, and probiotics.</p>

AB - <p>Complex and highly variable site-dependent bacterial ecosystems exist throughout the length of the human gastrointestinal tract. Until relatively recently, the majority of our information on intestinal microbiotas has come from studies on feces, or from aspirates taken from the upper gut. However, there is evidence showing that mucosal bacteria growing in biofilms on surfaces lining the gut differ from luminal populations, and that due to their proximity to the epithelial surface, these organisms may be important in modulating the host's immune system and contributing to some chronic inflammatory diseases. Over the past decade, increasing interest in mucosal bacteria, coupled with advances in molecular approaches for assessing microbial diversity, has begun to provide some insight into the complexity of these mucosa-associated communities. In gastrointestinal conditions such as inflammatory bowel diseases (ulcerative colitis, Crohn's disease), it has been shown that a dysbiosis exists in microbial community structure, and that there is a reduction in putatively protective mucosal organisms such as bifidobacteria. Therefore, manipulation of mucosal communities may be beneficial in restoring normal functionality in the gut, thereby improving the immune status and general health of the host. Biofilm structure and function has been studied intensively in the oral cavity, and as a consequence, mucosal communities in the mouth will not be covered in this chapter. This review addresses our current knowledge of mucosal populations in the gastrointestinal tract, changes that can occur in community structure in disease, and therapeutic modulation of biofilm composition by antibiotics, prebiotics, and probiotics.</p>

KW - Inflammatory bowel disease

KW - Invasive escherichia coli

KW - Sulfate reducing bacteria

KW - Gradient gel electrophoresis

KW - RDNA sequence analysis

KW - Human gastrointestinal tract

KW - Polymerase chain reaction

KW - Ileal Chron's disease

KW - 16S ribosomal RNA

KW - Human fecal flora

U2 - 10.1016/B978-0-12-387046-9.00005-0

DO - 10.1016/B978-0-12-387046-9.00005-0

M1 - Other chapter contribution

SN - 9780123870469

VL - 75

BT - Advances in applied microbiology

T2 - Advances in applied microbiology

A2 - Gadd,Geoffrey M.

ED - Gadd,Geoffrey M.

SP - 111

EP - 143

ER -

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