Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma. / Bavinck, Jan Nico Bouwes; Neale, Rachel E.; Abeni, Damiano; Euvrard, Sylvie; Green, Adele C.; Harwood, Catherine A.; de Koning, Maurits N. C.; Naldi, Luigi; Nindl, Ingo; Pawlita, Michael; Pfister, Herbert; Proby, Charlotte M.; Quint, Wim G. V.; ter Schegget, Jan; Waterboer, Tim; Weissenborn, Soenke; Feltkamp, Mariet C. W.; EPI-HPV-UV-CA Grp.
In: Cancer Research, Vol. 70, No. 23, 01.12.2010, p. 9777-9786.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma
A1 - Bavinck,Jan Nico Bouwes
A1 - Neale,Rachel E.
A1 - Abeni,Damiano
A1 - Euvrard,Sylvie
A1 - Green,Adele C.
A1 - Harwood,Catherine A.
A1 - de Koning,Maurits N. C.
A1 - Naldi,Luigi
A1 - Nindl,Ingo
A1 - Pawlita,Michael
A1 - Pfister,Herbert
A1 - Proby,Charlotte M.
A1 - Quint,Wim G. V.
A1 - ter Schegget,Jan
A1 - Waterboer,Tim
A1 - Weissenborn,Soenke
A1 - Feltkamp,Mariet C. W.
A1 - EPI-HPV-UV-CA Grp
AU - Bavinck,Jan Nico Bouwes
AU - Neale,Rachel E.
AU - Abeni,Damiano
AU - Euvrard,Sylvie
AU - Green,Adele C.
AU - Harwood,Catherine A.
AU - de Koning,Maurits N. C.
AU - Naldi,Luigi
AU - Nindl,Ingo
AU - Pawlita,Michael
AU - Pfister,Herbert
AU - Proby,Charlotte M.
AU - Quint,Wim G. V.
AU - ter Schegget,Jan
AU - Waterboer,Tim
AU - Weissenborn,Soenke
AU - Feltkamp,Mariet C. W.
AU - EPI-HPV-UV-CA Grp
PY - 2010/12/1
Y1 - 2010/12/1
N2 - <p>Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95% CI 1.3-5.8) and Italy (OR 1.7; 95% CI 0.79-3.6), but not in Australia (OR 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95% CI 1.4-3.3), the Netherlands (OR 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.</p>
AB - <p>Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95% CI 1.3-5.8) and Italy (OR 1.7; 95% CI 0.79-3.6), but not in Australia (OR 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95% CI 1.4-3.3), the Netherlands (OR 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.</p>
KW - HUMAN-PAPILLOMAVIRUS-DNA
KW - RENAL-TRANSPLANT RECIPIENTS
KW - KERATOTIC SKIN-LESIONS
KW - EPIDERMODYSPLASIA-VERRUCIFORMIS
KW - ACTINIC KERATOSES
KW - E6 PROTEINS
KW - INDUCED APOPTOSIS
KW - RISK-FACTORS
KW - CANCER
KW - BETA
U2 - 10.1158/0008-5472.CAN-10-0352
DO - 10.1158/0008-5472.CAN-10-0352
M1 - Article
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 23
VL - 70
SP - 9777
EP - 9786
ER -