Discovery - University of Dundee - Online Publications

Library & Learning Centre

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

Standard

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma. / Bavinck, Jan Nico Bouwes; Neale, Rachel E.; Abeni, Damiano; Euvrard, Sylvie; Green, Adele C.; Harwood, Catherine A.; de Koning, Maurits N. C.; Naldi, Luigi; Nindl, Ingo; Pawlita, Michael; Pfister, Herbert; Proby, Charlotte M.; Quint, Wim G. V.; ter Schegget, Jan; Waterboer, Tim; Weissenborn, Soenke; Feltkamp, Mariet C. W.; EPI-HPV-UV-CA Grp.

In: Cancer Research, Vol. 70, No. 23, 01.12.2010, p. 9777-9786.

Research output: Contribution to journalArticle

Harvard

Bavinck, JNB, Neale, RE, Abeni, D, Euvrard, S, Green, AC, Harwood, CA, de Koning, MNC, Naldi, L, Nindl, I, Pawlita, M, Pfister, H, Proby, CM, Quint, WGV, ter Schegget, J, Waterboer, T, Weissenborn, S, Feltkamp, MCW & EPI-HPV-UV-CA Grp 2010, 'Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma' Cancer Research, vol 70, no. 23, pp. 9777-9786.

APA

Bavinck, J. N. B., Neale, R. E., Abeni, D., Euvrard, S., Green, A. C., Harwood, C. A., de Koning, M. N. C., Naldi, L., Nindl, I., Pawlita, M., Pfister, H., Proby, C. M., Quint, W. G. V., ter Schegget, J., Waterboer, T., Weissenborn, S., Feltkamp, M. C. W., & EPI-HPV-UV-CA Grp (2010). Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma. Cancer Research, 70(23), 9777-9786doi: 10.1158/0008-5472.CAN-10-0352

Vancouver

Bavinck JNB, Neale RE, Abeni D, Euvrard S, Green AC, Harwood CA et al. Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma. Cancer Research. 2010 Dec 1;70(23):9777-9786.

Author

Bavinck, Jan Nico Bouwes; Neale, Rachel E.; Abeni, Damiano; Euvrard, Sylvie; Green, Adele C.; Harwood, Catherine A.; de Koning, Maurits N. C.; Naldi, Luigi; Nindl, Ingo; Pawlita, Michael; Pfister, Herbert; Proby, Charlotte M.; Quint, Wim G. V.; ter Schegget, Jan; Waterboer, Tim; Weissenborn, Soenke; Feltkamp, Mariet C. W.; EPI-HPV-UV-CA Grp / Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma.

In: Cancer Research, Vol. 70, No. 23, 01.12.2010, p. 9777-9786.

Research output: Contribution to journalArticle

Bibtex - Download

@article{52cf8a63153c440c810343001aba927c,
title = "Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma",
author = "Bavinck, {Jan Nico Bouwes} and Neale, {Rachel E.} and Damiano Abeni and Sylvie Euvrard and Green, {Adele C.} and Harwood, {Catherine A.} and {de Koning}, {Maurits N. C.} and Luigi Naldi and Ingo Nindl and Michael Pawlita and Herbert Pfister and Proby, {Charlotte M.} and Quint, {Wim G. V.} and {ter Schegget}, Jan and Tim Waterboer and Soenke Weissenborn and Feltkamp, {Mariet C. W.} and {EPI-HPV-UV-CA Grp}",
year = "2010",
volume = "70",
number = "23",
pages = "9777--9786",
journal = "Cancer Research",
issn = "0008-5472",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

A1 - Bavinck,Jan Nico Bouwes

A1 - Neale,Rachel E.

A1 - Abeni,Damiano

A1 - Euvrard,Sylvie

A1 - Green,Adele C.

A1 - Harwood,Catherine A.

A1 - de Koning,Maurits N. C.

A1 - Naldi,Luigi

A1 - Nindl,Ingo

A1 - Pawlita,Michael

A1 - Pfister,Herbert

A1 - Proby,Charlotte M.

A1 - Quint,Wim G. V.

A1 - ter Schegget,Jan

A1 - Waterboer,Tim

A1 - Weissenborn,Soenke

A1 - Feltkamp,Mariet C. W.

A1 - EPI-HPV-UV-CA Grp

AU - Bavinck,Jan Nico Bouwes

AU - Neale,Rachel E.

AU - Abeni,Damiano

AU - Euvrard,Sylvie

AU - Green,Adele C.

AU - Harwood,Catherine A.

AU - de Koning,Maurits N. C.

AU - Naldi,Luigi

AU - Nindl,Ingo

AU - Pawlita,Michael

AU - Pfister,Herbert

AU - Proby,Charlotte M.

AU - Quint,Wim G. V.

AU - ter Schegget,Jan

AU - Waterboer,Tim

AU - Weissenborn,Soenke

AU - Feltkamp,Mariet C. W.

AU - EPI-HPV-UV-CA Grp

PY - 2010/12/1

Y1 - 2010/12/1

N2 - <p>Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95% CI 1.3-5.8) and Italy (OR 1.7; 95% CI 0.79-3.6), but not in Australia (OR 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95% CI 1.4-3.3), the Netherlands (OR 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.</p>

AB - <p>Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95% CI 1.3-5.8) and Italy (OR 1.7; 95% CI 0.79-3.6), but not in Australia (OR 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95% CI 1.4-3.3), the Netherlands (OR 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.</p>

KW - HUMAN-PAPILLOMAVIRUS-DNA

KW - RENAL-TRANSPLANT RECIPIENTS

KW - KERATOTIC SKIN-LESIONS

KW - EPIDERMODYSPLASIA-VERRUCIFORMIS

KW - ACTINIC KERATOSES

KW - E6 PROTEINS

KW - INDUCED APOPTOSIS

KW - RISK-FACTORS

KW - CANCER

KW - BETA

U2 - 10.1158/0008-5472.CAN-10-0352

DO - 10.1158/0008-5472.CAN-10-0352

M1 - Article

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 23

VL - 70

SP - 9777

EP - 9786

ER -

Documents

Library & Learning Centre

Contact | Accessibility | Policy