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Neural differentiation of mouse embryonic stem cells

Neural differentiation of mouse embryonic stem cells

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Original languageEnglish
Pages45-49
Number of pages5
JournalBiochemical Society Transactions
Journal publication dateFeb 2003
Journal numberPt 1
Volume31
StatePublished

Abstract

Pluripotent embryonic stem cells can give rise to neuroectodermal derivatives in culture. This potential could be harnessed to generate neurons and glia for cell-replacement therapies in the central nervous system and for use in drug discovery. However, current methods of neural differentiation are empirical and relatively inefficient. Here, we review these methodologies and present new tools for quantification, analysis and manipulation of embryonic stem cell neural determination.

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