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Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro

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Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro. / Oldreive, Ceri E.; Harvey, Jenni; Doherty, Gayle H.

In: Neuroscience Letters, Vol. 438, No. 1, 2008, p. 17-21.

Research output: Contribution to journalArticle

Harvard

Oldreive, CE, Harvey, J & Doherty, GH 2008, 'Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro' Neuroscience Letters, vol 438, no. 1, pp. 17-21., 10.1016/j.neulet.2008.04.045

APA

Oldreive, C. E., Harvey, J., & Doherty, G. H. (2008). Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro. Neuroscience Letters, 438(1), 17-21. 10.1016/j.neulet.2008.04.045

Vancouver

Oldreive CE, Harvey J, Doherty GH. Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro. Neuroscience Letters. 2008;438(1):17-21. Available from: 10.1016/j.neulet.2008.04.045

Author

Oldreive, Ceri E.; Harvey, Jenni; Doherty, Gayle H. / Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro.

In: Neuroscience Letters, Vol. 438, No. 1, 2008, p. 17-21.

Research output: Contribution to journalArticle

Bibtex - Download

@article{659c65417c504153a62a692c078dd99d,
title = "Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro",
keywords = "cell death, cerebellum, leptin, granule, neurite, Purkinje, CELL-DEATH, HIPPOCAMPAL-NEURONS, EXPRESSION, BRAIN, HOMOCYSTEINE, APOPTOSIS, PROTECTS, RECEPTOR, MICE",
author = "Oldreive, {Ceri E.} and Jenni Harvey and Doherty, {Gayle H.}",
year = "2008",
doi = "10.1016/j.neulet.2008.04.045",
volume = "438",
number = "1",
pages = "17--21",
journal = "Neuroscience Letters",
issn = "0304-3940",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro

A1 - Oldreive,Ceri E.

A1 - Harvey,Jenni

A1 - Doherty,Gayle H.

AU - Oldreive,Ceri E.

AU - Harvey,Jenni

AU - Doherty,Gayle H.

PY - 2008

Y1 - 2008

N2 - <p>As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.</p>

AB - <p>As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.</p>

KW - cell death

KW - cerebellum

KW - leptin

KW - granule

KW - neurite

KW - Purkinje

KW - CELL-DEATH

KW - HIPPOCAMPAL-NEURONS

KW - EXPRESSION

KW - BRAIN

KW - HOMOCYSTEINE

KW - APOPTOSIS

KW - PROTECTS

KW - RECEPTOR

KW - MICE

U2 - 10.1016/j.neulet.2008.04.045

DO - 10.1016/j.neulet.2008.04.045

M1 - Article

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

VL - 438

SP - 17

EP - 21

ER -

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