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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. / Dupuis, Josee; Langenberg, Claudia; Prokopenko, Inga; Saxena, Richa; Soranzo, Nicole; Jackson, Anne U.; Wheeler, Eleanor; Glazer, Nicole L.; Bouatia-Naji, Nabila; Gloyn, Anna L.; Lindgren, Cecilia M.; Magi, Reedik; Morris, Andrew P.; Randall, Joshua; Johnson, Toby; Elliott, Paul; Rybin, Denis; Thorleifsson, Gudmar; Steinthorsdottir, Valgerdur; Henneman, Peter; Grallert, Harald; Dehghan, Abbas; Hottenga, Jouke Jan; Franklin, Christopher S.; Navarro, Pau; Song, Kijoung; Goel, Anuj; Perry, John R. B.; Egan, Josephine M.; Lajunen, Taina; Grarup, Niels; Sparso, Thomas; Doney, Alex S. F.; Voight, Benjamin F.; Stringham, Heather M.; Li, Man; Kanoni, Stavroula; Shrader, Peter; Cavalcanti-Proenca, Christine; Kumari, Meena; Qi, Lu; Timpson, Nicholas J.; Gieger, Christian; Zabena, Carina; Rocheleau, Ghislain; Ingelsson, Erik; An, Ping; O'Connell, Jeffrey; Luan, Jian'an; Elliott, Amanda; McCarroll, Steven A.; Payne, Felicity; Roccasecca, Rosa Maria; Pattou, Francois; Sethupathy, Praveen; Ardlie, Kristin; Ariyurek, Yavuz; Balkau, Beverley; Barter, Philip; Beilby, John P.; Ben-Shlomo, Yoav; Benediktsson, Rafn; Bennett, Amanda J.; Bergmann, Sven; Bochud, Murielle; Boerwinkle, Eric; Bonnefond, Amelie; Bonnycastle, Lori L.; Borch-Johnsen, Knut; Boettcher, Yvonne; Brunner, Eric; Bumpstead, Suzannah J.; Charpentier, Guillaume; Chen, Yii-Der Ida; Chines, Peter; Clarke, Robert; Coin, Lachlan J. M.; Cooper, Matthew N.; Cornelis, Marilyn; Crawford, Gabe; Crisponi, Laura; Day, Ian N. M.; de Geus, Eco J. C.; Delplanque, Jerome; Dina, Christian; Erdos, Michael R.; Fedson, Annette C.; Fischer-Rosinsky, Antje; Forouhi, Nita G.; Fox, Caroline S.; Frants, Rune; Franzosi, Maria Grazia; Galan, Pilar; Goodarzi, Mark O.; Graessler, Juergen; Groves, Christopher J.; Grundy, Scott; Gwilliam, Rhian; Gyllensten, Ulf; Hadjadj, Samy; Hallmans, Goeran; Hammond, Naomi; Han, Xijing; Hartikainen, Anna-Liisa; Hassanali, Neelam; Hayward, Caroline; Heath, Simon C.; Hercberg, Serge; Herder, Christian; Hicks, Andrew A.; Hillman, David R.; Hingorani, Aroon D.; Hofman, Albert; Hui, Jennie; Hung, Joe; Isomaa, Bo; Johnson, Paul R. V.; Jorgensen, Torben; Jula, Antti; Kaakinen, Marika; Kaprio, Jaakko; Kesaniemi, Y. Antero; Kivimaki, Mika; Knight, Beatrice; Koskinen, Seppo; Kovacs, Peter; Kyvik, Kirsten Ohm; Lathrop, G. Mark; Lawlor, Debbie A.; Le Bacquer, Olivier; Lecoeur, Cecile; Li, Yun; Lyssenko, Valeriya; Mahley, Robert; Mangino, Massimo; Manning, Alisa K.; Teresa Martinez-Larrad, Maria; McAteer, Jarred B.; McCulloch, Laura J.; McPherson, Ruth; Meisinger, Christa; Melzer, David; Meyre, David; Mitchell, Braxton D.; Morken, Mario A.; Mukherjee, Sutapa; Naitza, Silvia; Narisu, Narisu; Neville, Matthew J.; Oostra, Ben A.; Orru, Marco; Pakyz, Ruth; Palmer, Colin N. A.; Paolisso, Giuseppe; Pattaro, Cristian; Pearson, Daniel; Peden, John F.; Pedersen, Nancy L.; Perola, Markus; Pfeiffer, Andreas F. H.; Pichler, Irene; Polasek, Ozren; Posthuma, Danielle; Potter, Simon C.; Pouta, Anneli; Province, Michael A.; Psaty, Bruce M.; Rathmann, Wolfgang; Rayner, Nigel W.; Rice, Kenneth; Ripatti, Samuli; Rivadeneira, Fernando; Roden, Michael; Rolandsson, Olov; Sandbaek, Annelli; Sandhu, Manjinder; Sanna, Serena; Sayer, Avan Aihie; Scheet, Paul; Scott, Laura J.; Seedorf, Udo; Sharp, Stephen J.; Shields, Beverley; Sigurosson, Gunnar; Sijbrands, Eric J. G.; Silveira, Angela; Simpson, Laila; Singleton, Andrew; Smith, Nicholas L.; Sovio, Ulla; Swift, Amy; Syddall, Holly; Syvanen, Ann-Christine; Tanaka, Toshiko; Thorand, Barbara; Tichet, Jean; Tonjes, Anke; Tuomi, Tiinamaija; Uitterlinden, Andre G.; van Dijk, Ko Willems; van Hoek, Mandy; Varma, Dhiraj; Visvikis-Siest, Sophie; Vitart, Veronique; Vogelzangs, Nicole; Waeber, Gerard; Wagner, Peter J.; Walley, Andrew; Walters, G. Bragi; Ward, Kim L.; Watkins, Hugh; Weedon, Michael N.; Wild, Sarah H.; Willemsen, Gonneke; Witteman, Jaqueline C. M.; Yarnell, John W. G.; Zeggini, Eleftheria; Zelenika, Diana; Zethelius, Bjorn; Zhai, Guangju; Zhao, Jing Hua; Zillikens, M. Carola; Borecki, Ingrid B.; Loos, Ruth J. F.; Meneton, Pierre; Magnusson, Patrik K. E.; Nathan, David M.; Williams, Gordon H.; Hattersley, Andrew T.; Silander, Kaisa; Salomaa, Veikko; Smith, George Davey; Bornstein, Stefan R.; Schwarz, Peter; Spranger, Joachim; Karpe, Fredrik; Shuldiner, Alan R.; Cooper, Cyrus; Dedoussis, George V.; Serrano-Rios, Manuel; Morris, Andrew D.; Lind, Lars; Palmer, Lyle J.; Hu, Frank B.; Franks, Paul W.; Ebrahim, Shah; Marmot, Michael; Kao, W. H. Linda; Pankow, James S.; Sampson, Michael J.; Kuusisto, Johanna; Laakso, Markku; Hansen, Torben; Pedersen, Oluf; Pramstaller, Peter Paul; Wichmann, H. Erich; Illig, Thomas; Rudan, Igor; Wright, Alan F.; Stumvoll, Michael; Campbell, Harry; Wilson, James F.; Bergman, Richard N.; Buchanan, Thomas A.; Collins, Francis S.; Mohlke, Karen L.; Tuomilehto, Jaakko; Valle, Timo T.; Altshuler, David; Rotter, Jerome I.; Siscovick, David S.; Penninx, Brenda W. J. H.; Boomsma, Dorret I.; Deloukas, Panos; Spector, Timothy D.; Frayling, Timothy M.; Ferrucci, Luigi; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari; van Duijn, Cornelia M.; Aulchenko, Yurii S.; Cao, Antonio; Scuteri, Angelo; Schlessinger, David; Uda, Manuela; Ruokonen, Aimo; Jarvelin, Marjo-Riitta; Waterworth, Dawn M.; Vollenweider, Peter; Peltonen, Leena; Mooser, Vincent; Abecasis, Goncalo R.; Wareham, Nicholas J.; Sladek, Robert; Froguel, Philippe; Watanabe, Richard M.; Meigs, James B.; Groop, Leif; Boehnke, Michael; McCarthy, Mark I.; Florez, Jose C.; Barroso, Ines; Anders Hamsten Procardis Consortiu, Global BPgen Consortium, GIANT Consortium, DIAGRAM Consortium, MAGIC Investigators.

In: Nature Genetics, Vol. 42, No. 2, 02.2010, p. 105-116.

Research output: Contribution to journalArticle

Harvard

Dupuis, J, Langenberg, C, Prokopenko, I, Saxena, R, Soranzo, N, Jackson, AU, Wheeler, E, Glazer, NL, Bouatia-Naji, N, Gloyn, AL, Lindgren, CM, Magi, R, Morris, AP, Randall, J, Johnson, T, Elliott, P, Rybin, D, Thorleifsson, G, Steinthorsdottir, V, Henneman, P, Grallert, H, Dehghan, A, Hottenga, JJ, Franklin, CS, Navarro, P, Song, K, Goel, A, Perry, JRB, Egan, JM, Lajunen, T, Grarup, N, Sparso, T, Doney, ASF, Voight, BF, Stringham, HM, Li, M, Kanoni, S, Shrader, P, Cavalcanti-Proenca, C, Kumari, M, Qi, L, Timpson, NJ, Gieger, C, Zabena, C, Rocheleau, G, Ingelsson, E, An, P, O'Connell, J, Luan, J, Elliott, A, McCarroll, SA, Payne, F, Roccasecca, RM, Pattou, F, Sethupathy, P, Ardlie, K, Ariyurek, Y, Balkau, B, Barter, P, Beilby, JP, Ben-Shlomo, Y, Benediktsson, R, Bennett, AJ, Bergmann, S, Bochud, M, Boerwinkle, E, Bonnefond, A, Bonnycastle, LL, Borch-Johnsen, K, Boettcher, Y, Brunner, E, Bumpstead, SJ, Charpentier, G, Chen, Y-DI, Chines, P, Clarke, R, Coin, LJM, Cooper, MN, Cornelis, M, Crawford, G, Crisponi, L, Day, INM, de Geus, EJC, Delplanque, J, Dina, C, Erdos, MR, Fedson, AC, Fischer-Rosinsky, A, Forouhi, NG, Fox, CS, Frants, R, Franzosi, MG, Galan, P, Goodarzi, MO, Graessler, J, Groves, CJ, Grundy, S, Gwilliam, R, Gyllensten, U, Hadjadj, S, Hallmans, G, Hammond, N, Han, X, Hartikainen, A-L, Hassanali, N, Hayward, C, Heath, SC, Hercberg, S, Herder, C, Hicks, AA, Hillman, DR, Hingorani, AD, Hofman, A, Hui, J, Hung, J, Isomaa, B, Johnson, PRV, Jorgensen, T, Jula, A, Kaakinen, M, Kaprio, J, Kesaniemi, YA, Kivimaki, M, Knight, B, Koskinen, S, Kovacs, P, Kyvik, KO, Lathrop, GM, Lawlor, DA, Le Bacquer, O, Lecoeur, C, Li, Y, Lyssenko, V, Mahley, R, Mangino, M, Manning, AK, Teresa Martinez-Larrad, M, McAteer, JB, McCulloch, LJ, McPherson, R, Meisinger, C, Melzer, D, Meyre, D, Mitchell, BD, Morken, MA, Mukherjee, S, Naitza, S, Narisu, N, Neville, MJ, Oostra, BA, Orru, M, Pakyz, R, Palmer, CNA, Paolisso, G, Pattaro, C, Pearson, D, Peden, JF, Pedersen, NL, Perola, M, Pfeiffer, AFH, Pichler, I, Polasek, O, Posthuma, D, Potter, SC, Pouta, A, Province, MA, Psaty, BM, Rathmann, W, Rayner, NW, Rice, K, Ripatti, S, Rivadeneira, F, Roden, M, Rolandsson, O, Sandbaek, A, Sandhu, M, Sanna, S, Sayer, AA, Scheet, P, Scott, LJ, Seedorf, U, Sharp, SJ, Shields, B, Sigurosson, G, Sijbrands, EJG, Silveira, A, Simpson, L, Singleton, A, Smith, NL, Sovio, U, Swift, A, Syddall, H, Syvanen, A-C, Tanaka, T, Thorand, B, Tichet, J, Tonjes, A, Tuomi, T, Uitterlinden, AG, van Dijk, KW, van Hoek, M, Varma, D, Visvikis-Siest, S, Vitart, V, Vogelzangs, N, Waeber, G, Wagner, PJ, Walley, A, Walters, GB, Ward, KL, Watkins, H, Weedon, MN, Wild, SH, Willemsen, G, Witteman, JCM, Yarnell, JWG, Zeggini, E, Zelenika, D, Zethelius, B, Zhai, G, Zhao, JH, Zillikens, MC, Borecki, IB, Loos, RJF, Meneton, P, Magnusson, PKE, Nathan, DM, Williams, GH, Hattersley, AT, Silander, K, Salomaa, V, Smith, GD, Bornstein, SR, Schwarz, P, Spranger, J, Karpe, F, Shuldiner, AR, Cooper, C, Dedoussis, GV, Serrano-Rios, M, Morris, AD, Lind, L, Palmer, LJ, Hu, FB, Franks, PW, Ebrahim, S, Marmot, M, Kao, WHL, Pankow, JS, Sampson, MJ, Kuusisto, J, Laakso, M, Hansen, T, Pedersen, O, Pramstaller, PP, Wichmann, HE, Illig, T, Rudan, I, Wright, AF, Stumvoll, M, Campbell, H, Wilson, JF, Bergman, RN, Buchanan, TA, Collins, FS, Mohlke, KL, Tuomilehto, J, Valle, TT, Altshuler, D, Rotter, JI, Siscovick, DS, Penninx, BWJH, Boomsma, DI, Deloukas, P, Spector, TD, Frayling, TM, Ferrucci, L, Kong, A, Thorsteinsdottir, U, Stefansson, K, van Duijn, CM, Aulchenko, YS, Cao, A, Scuteri, A, Schlessinger, D, Uda, M, Ruokonen, A, Jarvelin, M-R, Waterworth, DM, Vollenweider, P, Peltonen, L, Mooser, V, Abecasis, GR, Wareham, NJ, Sladek, R, Froguel, P, Watanabe, RM, Meigs, JB, Groop, L, Boehnke, M, McCarthy, MI, Florez, JC, Barroso, I & Anders Hamsten Procardis Consortiu, Global BPgen Consortium, GIANT Consortium, DIAGRAM Consortium, MAGIC Investigators 2010, 'New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk' Nature Genetics, vol 42, no. 2, pp. 105-116.

APA

Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Magi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P., Grallert, H., Dehghan, A., Hottenga, J. J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparso, T., Doney, A. S. F., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proenca, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Boettcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Chen, Y-D. I., Chines, P., Clarke, R., Coin, L. J. M., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., de Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., Franzosi, M. G., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., Hartikainen, A-L., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jorgensen, T., Jula, A., Kaakinen, M., Kaprio, J., Kesaniemi, Y. A., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Le Bacquer, O., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., Teresa Martinez-Larrad, M., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orru, M., Pakyz, R., Palmer, C. N. A., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigurosson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., Syvanen, A-C., Tanaka, T., Thorand, B., Tichet, J., Tonjes, A., Tuomi, T., Uitterlinden, A. G., van Dijk, K. W., van Hoek, M., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., Walters, G. B., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., Witteman, J. C. M., Yarnell, J. W. G., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Rios, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Kao, W. H. L., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., Jarvelin, M-R., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C., Barroso, I., & Anders Hamsten Procardis Consortiu, Global BPgen Consortium, GIANT Consortium, DIAGRAM Consortium, MAGIC Investigators (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42(2), 105-116doi: 10.1038/ng.520

Vancouver

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics. 2010 Feb;42(2):105-116.

Author

Dupuis, Josee; Langenberg, Claudia; Prokopenko, Inga; Saxena, Richa; Soranzo, Nicole; Jackson, Anne U.; Wheeler, Eleanor; Glazer, Nicole L.; Bouatia-Naji, Nabila; Gloyn, Anna L.; Lindgren, Cecilia M.; Magi, Reedik; Morris, Andrew P.; Randall, Joshua; Johnson, Toby; Elliott, Paul; Rybin, Denis; Thorleifsson, Gudmar; Steinthorsdottir, Valgerdur; Henneman, Peter; Grallert, Harald; Dehghan, Abbas; Hottenga, Jouke Jan; Franklin, Christopher S.; Navarro, Pau; Song, Kijoung; Goel, Anuj; Perry, John R. B.; Egan, Josephine M.; Lajunen, Taina; Grarup, Niels; Sparso, Thomas; Doney, Alex S. F.; Voight, Benjamin F.; Stringham, Heather M.; Li, Man; Kanoni, Stavroula; Shrader, Peter; Cavalcanti-Proenca, Christine; Kumari, Meena; Qi, Lu; Timpson, Nicholas J.; Gieger, Christian; Zabena, Carina; Rocheleau, Ghislain; Ingelsson, Erik; An, Ping; O'Connell, Jeffrey; Luan, Jian'an; Elliott, Amanda; McCarroll, Steven A.; Payne, Felicity; Roccasecca, Rosa Maria; Pattou, Francois; Sethupathy, Praveen; Ardlie, Kristin; Ariyurek, Yavuz; Balkau, Beverley; Barter, Philip; Beilby, John P.; Ben-Shlomo, Yoav; Benediktsson, Rafn; Bennett, Amanda J.; Bergmann, Sven; Bochud, Murielle; Boerwinkle, Eric; Bonnefond, Amelie; Bonnycastle, Lori L.; Borch-Johnsen, Knut; Boettcher, Yvonne; Brunner, Eric; Bumpstead, Suzannah J.; Charpentier, Guillaume; Chen, Yii-Der Ida; Chines, Peter; Clarke, Robert; Coin, Lachlan J. M.; Cooper, Matthew N.; Cornelis, Marilyn; Crawford, Gabe; Crisponi, Laura; Day, Ian N. M.; de Geus, Eco J. C.; Delplanque, Jerome; Dina, Christian; Erdos, Michael R.; Fedson, Annette C.; Fischer-Rosinsky, Antje; Forouhi, Nita G.; Fox, Caroline S.; Frants, Rune; Franzosi, Maria Grazia; Galan, Pilar; Goodarzi, Mark O.; Graessler, Juergen; Groves, Christopher J.; Grundy, Scott; Gwilliam, Rhian; Gyllensten, Ulf; Hadjadj, Samy; Hallmans, Goeran; Hammond, Naomi; Han, Xijing; Hartikainen, Anna-Liisa; Hassanali, Neelam; Hayward, Caroline; Heath, Simon C.; Hercberg, Serge; Herder, Christian; Hicks, Andrew A.; Hillman, David R.; Hingorani, Aroon D.; Hofman, Albert; Hui, Jennie; Hung, Joe; Isomaa, Bo; Johnson, Paul R. V.; Jorgensen, Torben; Jula, Antti; Kaakinen, Marika; Kaprio, Jaakko; Kesaniemi, Y. Antero; Kivimaki, Mika; Knight, Beatrice; Koskinen, Seppo; Kovacs, Peter; Kyvik, Kirsten Ohm; Lathrop, G. Mark; Lawlor, Debbie A.; Le Bacquer, Olivier; Lecoeur, Cecile; Li, Yun; Lyssenko, Valeriya; Mahley, Robert; Mangino, Massimo; Manning, Alisa K.; Teresa Martinez-Larrad, Maria; McAteer, Jarred B.; McCulloch, Laura J.; McPherson, Ruth; Meisinger, Christa; Melzer, David; Meyre, David; Mitchell, Braxton D.; Morken, Mario A.; Mukherjee, Sutapa; Naitza, Silvia; Narisu, Narisu; Neville, Matthew J.; Oostra, Ben A.; Orru, Marco; Pakyz, Ruth; Palmer, Colin N. A.; Paolisso, Giuseppe; Pattaro, Cristian; Pearson, Daniel; Peden, John F.; Pedersen, Nancy L.; Perola, Markus; Pfeiffer, Andreas F. H.; Pichler, Irene; Polasek, Ozren; Posthuma, Danielle; Potter, Simon C.; Pouta, Anneli; Province, Michael A.; Psaty, Bruce M.; Rathmann, Wolfgang; Rayner, Nigel W.; Rice, Kenneth; Ripatti, Samuli; Rivadeneira, Fernando; Roden, Michael; Rolandsson, Olov; Sandbaek, Annelli; Sandhu, Manjinder; Sanna, Serena; Sayer, Avan Aihie; Scheet, Paul; Scott, Laura J.; Seedorf, Udo; Sharp, Stephen J.; Shields, Beverley; Sigurosson, Gunnar; Sijbrands, Eric J. G.; Silveira, Angela; Simpson, Laila; Singleton, Andrew; Smith, Nicholas L.; Sovio, Ulla; Swift, Amy; Syddall, Holly; Syvanen, Ann-Christine; Tanaka, Toshiko; Thorand, Barbara; Tichet, Jean; Tonjes, Anke; Tuomi, Tiinamaija; Uitterlinden, Andre G.; van Dijk, Ko Willems; van Hoek, Mandy; Varma, Dhiraj; Visvikis-Siest, Sophie; Vitart, Veronique; Vogelzangs, Nicole; Waeber, Gerard; Wagner, Peter J.; Walley, Andrew; Walters, G. Bragi; Ward, Kim L.; Watkins, Hugh; Weedon, Michael N.; Wild, Sarah H.; Willemsen, Gonneke; Witteman, Jaqueline C. M.; Yarnell, John W. G.; Zeggini, Eleftheria; Zelenika, Diana; Zethelius, Bjorn; Zhai, Guangju; Zhao, Jing Hua; Zillikens, M. Carola; Borecki, Ingrid B.; Loos, Ruth J. F.; Meneton, Pierre; Magnusson, Patrik K. E.; Nathan, David M.; Williams, Gordon H.; Hattersley, Andrew T.; Silander, Kaisa; Salomaa, Veikko; Smith, George Davey; Bornstein, Stefan R.; Schwarz, Peter; Spranger, Joachim; Karpe, Fredrik; Shuldiner, Alan R.; Cooper, Cyrus; Dedoussis, George V.; Serrano-Rios, Manuel; Morris, Andrew D.; Lind, Lars; Palmer, Lyle J.; Hu, Frank B.; Franks, Paul W.; Ebrahim, Shah; Marmot, Michael; Kao, W. H. Linda; Pankow, James S.; Sampson, Michael J.; Kuusisto, Johanna; Laakso, Markku; Hansen, Torben; Pedersen, Oluf; Pramstaller, Peter Paul; Wichmann, H. Erich; Illig, Thomas; Rudan, Igor; Wright, Alan F.; Stumvoll, Michael; Campbell, Harry; Wilson, James F.; Bergman, Richard N.; Buchanan, Thomas A.; Collins, Francis S.; Mohlke, Karen L.; Tuomilehto, Jaakko; Valle, Timo T.; Altshuler, David; Rotter, Jerome I.; Siscovick, David S.; Penninx, Brenda W. J. H.; Boomsma, Dorret I.; Deloukas, Panos; Spector, Timothy D.; Frayling, Timothy M.; Ferrucci, Luigi; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari; van Duijn, Cornelia M.; Aulchenko, Yurii S.; Cao, Antonio; Scuteri, Angelo; Schlessinger, David; Uda, Manuela; Ruokonen, Aimo; Jarvelin, Marjo-Riitta; Waterworth, Dawn M.; Vollenweider, Peter; Peltonen, Leena; Mooser, Vincent; Abecasis, Goncalo R.; Wareham, Nicholas J.; Sladek, Robert; Froguel, Philippe; Watanabe, Richard M.; Meigs, James B.; Groop, Leif; Boehnke, Michael; McCarthy, Mark I.; Florez, Jose C.; Barroso, Ines; Anders Hamsten Procardis Consortiu, Global BPgen Consortium, GIANT Consortium, DIAGRAM Consortium, MAGIC Investigators / New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

In: Nature Genetics, Vol. 42, No. 2, 02.2010, p. 105-116.

Research output: Contribution to journalArticle

Bibtex - Download

@article{3014b8c73b234fd590a4742c8479aea0,
title = "New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk",
author = "Josee Dupuis and Claudia Langenberg and Inga Prokopenko and Richa Saxena and Nicole Soranzo and Jackson, {Anne U.} and Eleanor Wheeler and Glazer, {Nicole L.} and Nabila Bouatia-Naji and Gloyn, {Anna L.} and Lindgren, {Cecilia M.} and Reedik Magi and Morris, {Andrew P.} and Joshua Randall and Toby Johnson and Paul Elliott and Denis Rybin and Gudmar Thorleifsson and Valgerdur Steinthorsdottir and Peter Henneman and Harald Grallert and Abbas Dehghan and Hottenga, {Jouke Jan} and Franklin, {Christopher S.} and Pau Navarro and Kijoung Song and Anuj Goel and Perry, {John R. B.} and Egan, {Josephine M.} and Taina Lajunen and Niels Grarup and Thomas Sparso and Doney, {Alex S. F.} and Voight, {Benjamin F.} and Stringham, {Heather M.} and Man Li and Stavroula Kanoni and Peter Shrader and Christine Cavalcanti-Proenca and Meena Kumari and Lu Qi and Timpson, {Nicholas J.} and Christian Gieger and Carina Zabena and Ghislain Rocheleau and Erik Ingelsson and Ping An and Jeffrey O'Connell and Jian'an Luan and Amanda Elliott and McCarroll, {Steven A.} and Felicity Payne and Roccasecca, {Rosa Maria} and Francois Pattou and Praveen Sethupathy and Kristin Ardlie and Yavuz Ariyurek and Beverley Balkau and Philip Barter and Beilby, {John P.} and Yoav Ben-Shlomo and Rafn Benediktsson and Bennett, {Amanda J.} and Sven Bergmann and Murielle Bochud and Eric Boerwinkle and Amelie Bonnefond and Bonnycastle, {Lori L.} and Knut Borch-Johnsen and Yvonne Boettcher and Eric Brunner and Bumpstead, {Suzannah J.} and Guillaume Charpentier and Chen, {Yii-Der Ida} and Peter Chines and Robert Clarke and Coin, {Lachlan J. M.} and Cooper, {Matthew N.} and Marilyn Cornelis and Gabe Crawford and Laura Crisponi and Day, {Ian N. M.} and {de Geus}, {Eco J. C.} and Jerome Delplanque and Christian Dina and Erdos, {Michael R.} and Fedson, {Annette C.} and Antje Fischer-Rosinsky and Forouhi, {Nita G.} and Fox, {Caroline S.} and Rune Frants and Franzosi, {Maria Grazia} and Pilar Galan and Goodarzi, {Mark O.} and Juergen Graessler and Groves, {Christopher J.} and Scott Grundy and Rhian Gwilliam and Ulf Gyllensten and Samy Hadjadj and Goeran Hallmans and Naomi Hammond and Xijing Han and Anna-Liisa Hartikainen and Neelam Hassanali and Caroline Hayward and Heath, {Simon C.} and Serge Hercberg and Christian Herder and Hicks, {Andrew A.} and Hillman, {David R.} and Hingorani, {Aroon D.} and Albert Hofman and Jennie Hui and Joe Hung and Bo Isomaa and Johnson, {Paul R. V.} and Torben Jorgensen and Antti Jula and Marika Kaakinen and Jaakko Kaprio and Kesaniemi, {Y. Antero} and Mika Kivimaki and Beatrice Knight and Seppo Koskinen and Peter Kovacs and Kyvik, {Kirsten Ohm} and Lathrop, {G. Mark} and Lawlor, {Debbie A.} and {Le Bacquer}, Olivier and Cecile Lecoeur and Yun Li and Valeriya Lyssenko and Robert Mahley and Massimo Mangino and Manning, {Alisa K.} and {Teresa Martinez-Larrad}, Maria and McAteer, {Jarred B.} and McCulloch, {Laura J.} and Ruth McPherson and Christa Meisinger and David Melzer and David Meyre and Mitchell, {Braxton D.} and Morken, {Mario A.} and Sutapa Mukherjee and Silvia Naitza and Narisu Narisu and Neville, {Matthew J.} and Oostra, {Ben A.} and Marco Orru and Ruth Pakyz and Palmer, {Colin N. A.} and Giuseppe Paolisso and Cristian Pattaro and Daniel Pearson and Peden, {John F.} and Pedersen, {Nancy L.} and Markus Perola and Pfeiffer, {Andreas F. H.} and Irene Pichler and Ozren Polasek and Danielle Posthuma and Potter, {Simon C.} and Anneli Pouta and Province, {Michael A.} and Psaty, {Bruce M.} and Wolfgang Rathmann and Rayner, {Nigel W.} and Kenneth Rice and Samuli Ripatti and Fernando Rivadeneira and Michael Roden and Olov Rolandsson and Annelli Sandbaek and Manjinder Sandhu and Serena Sanna and Sayer, {Avan Aihie} and Paul Scheet and Scott, {Laura J.} and Udo Seedorf and Sharp, {Stephen J.} and Beverley Shields and Gunnar Sigurosson and Sijbrands, {Eric J. G.} and Angela Silveira and Laila Simpson and Andrew Singleton and Smith, {Nicholas L.} and Ulla Sovio and Amy Swift and Holly Syddall and Ann-Christine Syvanen and Toshiko Tanaka and Barbara Thorand and Jean Tichet and Anke Tonjes and Tiinamaija Tuomi and Uitterlinden, {Andre G.} and {van Dijk}, {Ko Willems} and {van Hoek}, Mandy and Dhiraj Varma and Sophie Visvikis-Siest and Veronique Vitart and Nicole Vogelzangs and Gerard Waeber and Wagner, {Peter J.} and Andrew Walley and Walters, {G. Bragi} and Ward, {Kim L.} and Hugh Watkins and Weedon, {Michael N.} and Wild, {Sarah H.} and Gonneke Willemsen and Witteman, {Jaqueline C. M.} and Yarnell, {John W. G.} and Eleftheria Zeggini and Diana Zelenika and Bjorn Zethelius and Guangju Zhai and Zhao, {Jing Hua} and Zillikens, {M. Carola} and Borecki, {Ingrid B.} and Loos, {Ruth J. F.} and Pierre Meneton and Magnusson, {Patrik K. E.} and Nathan, {David M.} and Williams, {Gordon H.} and Hattersley, {Andrew T.} and Kaisa Silander and Veikko Salomaa and Smith, {George Davey} and Bornstein, {Stefan R.} and Peter Schwarz and Joachim Spranger and Fredrik Karpe and Shuldiner, {Alan R.} and Cyrus Cooper and Dedoussis, {George V.} and Manuel Serrano-Rios and Morris, {Andrew D.} and Lars Lind and Palmer, {Lyle J.} and Hu, {Frank B.} and Franks, {Paul W.} and Shah Ebrahim and Michael Marmot and Kao, {W. H. Linda} and Pankow, {James S.} and Sampson, {Michael J.} and Johanna Kuusisto and Markku Laakso and Torben Hansen and Oluf Pedersen and Pramstaller, {Peter Paul} and Wichmann, {H. Erich} and Thomas Illig and Igor Rudan and Wright, {Alan F.} and Michael Stumvoll and Harry Campbell and Wilson, {James F.} and Bergman, {Richard N.} and Buchanan, {Thomas A.} and Collins, {Francis S.} and Mohlke, {Karen L.} and Jaakko Tuomilehto and Valle, {Timo T.} and David Altshuler and Rotter, {Jerome I.} and Siscovick, {David S.} and Penninx, {Brenda W. J. H.} and Boomsma, {Dorret I.} and Panos Deloukas and Spector, {Timothy D.} and Frayling, {Timothy M.} and Luigi Ferrucci and Augustine Kong and Unnur Thorsteinsdottir and Kari Stefansson and {van Duijn}, {Cornelia M.} and Aulchenko, {Yurii S.} and Antonio Cao and Angelo Scuteri and David Schlessinger and Manuela Uda and Aimo Ruokonen and Marjo-Riitta Jarvelin and Waterworth, {Dawn M.} and Peter Vollenweider and Leena Peltonen and Vincent Mooser and Abecasis, {Goncalo R.} and Wareham, {Nicholas J.} and Robert Sladek and Philippe Froguel and Watanabe, {Richard M.} and Meigs, {James B.} and Leif Groop and Michael Boehnke and McCarthy, {Mark I.} and Florez, {Jose C.} and Ines Barroso and {Anders Hamsten Procardis Consortiu, Global BPgen Consortium, GIANT Consortium, DIAGRAM Consortium, MAGIC Investigators}",
year = "2010",
volume = "42",
number = "2",
pages = "105--116",
journal = "Nature Genetics",
issn = "1061-4036",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

A1 - Dupuis,Josee

A1 - Langenberg,Claudia

A1 - Prokopenko,Inga

A1 - Saxena,Richa

A1 - Soranzo,Nicole

A1 - Jackson,Anne U.

A1 - Wheeler,Eleanor

A1 - Glazer,Nicole L.

A1 - Bouatia-Naji,Nabila

A1 - Gloyn,Anna L.

A1 - Lindgren,Cecilia M.

A1 - Magi,Reedik

A1 - Morris,Andrew P.

A1 - Randall,Joshua

A1 - Johnson,Toby

A1 - Elliott,Paul

A1 - Rybin,Denis

A1 - Thorleifsson,Gudmar

A1 - Steinthorsdottir,Valgerdur

A1 - Henneman,Peter

A1 - Grallert,Harald

A1 - Dehghan,Abbas

A1 - Hottenga,Jouke Jan

A1 - Franklin,Christopher S.

A1 - Navarro,Pau

A1 - Song,Kijoung

A1 - Goel,Anuj

A1 - Perry,John R. B.

A1 - Egan,Josephine M.

A1 - Lajunen,Taina

A1 - Grarup,Niels

A1 - Sparso,Thomas

A1 - Doney,Alex S. F.

A1 - Voight,Benjamin F.

A1 - Stringham,Heather M.

A1 - Li,Man

A1 - Kanoni,Stavroula

A1 - Shrader,Peter

A1 - Cavalcanti-Proenca,Christine

A1 - Kumari,Meena

A1 - Qi,Lu

A1 - Timpson,Nicholas J.

A1 - Gieger,Christian

A1 - Zabena,Carina

A1 - Rocheleau,Ghislain

A1 - Ingelsson,Erik

A1 - An,Ping

A1 - O'Connell,Jeffrey

A1 - Luan,Jian'an

A1 - Elliott,Amanda

A1 - McCarroll,Steven A.

A1 - Payne,Felicity

A1 - Roccasecca,Rosa Maria

A1 - Pattou,Francois

A1 - Sethupathy,Praveen

A1 - Ardlie,Kristin

A1 - Ariyurek,Yavuz

A1 - Balkau,Beverley

A1 - Barter,Philip

A1 - Beilby,John P.

A1 - Ben-Shlomo,Yoav

A1 - Benediktsson,Rafn

A1 - Bennett,Amanda J.

A1 - Bergmann,Sven

A1 - Bochud,Murielle

A1 - Boerwinkle,Eric

A1 - Bonnefond,Amelie

A1 - Bonnycastle,Lori L.

A1 - Borch-Johnsen,Knut

A1 - Boettcher,Yvonne

A1 - Brunner,Eric

A1 - Bumpstead,Suzannah J.

A1 - Charpentier,Guillaume

A1 - Chen,Yii-Der Ida

A1 - Chines,Peter

A1 - Clarke,Robert

A1 - Coin,Lachlan J. M.

A1 - Cooper,Matthew N.

A1 - Cornelis,Marilyn

A1 - Crawford,Gabe

A1 - Crisponi,Laura

A1 - Day,Ian N. M.

A1 - de Geus,Eco J. C.

A1 - Delplanque,Jerome

A1 - Dina,Christian

A1 - Erdos,Michael R.

A1 - Fedson,Annette C.

A1 - Fischer-Rosinsky,Antje

A1 - Forouhi,Nita G.

A1 - Fox,Caroline S.

A1 - Frants,Rune

A1 - Franzosi,Maria Grazia

A1 - Galan,Pilar

A1 - Goodarzi,Mark O.

A1 - Graessler,Juergen

A1 - Groves,Christopher J.

A1 - Grundy,Scott

A1 - Gwilliam,Rhian

A1 - Gyllensten,Ulf

A1 - Hadjadj,Samy

A1 - Hallmans,Goeran

A1 - Hammond,Naomi

A1 - Han,Xijing

A1 - Hartikainen,Anna-Liisa

A1 - Hassanali,Neelam

A1 - Hayward,Caroline

A1 - Heath,Simon C.

A1 - Hercberg,Serge

A1 - Herder,Christian

A1 - Hicks,Andrew A.

A1 - Hillman,David R.

A1 - Hingorani,Aroon D.

A1 - Hofman,Albert

A1 - Hui,Jennie

A1 - Hung,Joe

A1 - Isomaa,Bo

A1 - Johnson,Paul R. V.

A1 - Jorgensen,Torben

A1 - Jula,Antti

A1 - Kaakinen,Marika

A1 - Kaprio,Jaakko

A1 - Kesaniemi,Y. Antero

A1 - Kivimaki,Mika

A1 - Knight,Beatrice

A1 - Koskinen,Seppo

A1 - Kovacs,Peter

A1 - Kyvik,Kirsten Ohm

A1 - Lathrop,G. Mark

A1 - Lawlor,Debbie A.

A1 - Le Bacquer,Olivier

A1 - Lecoeur,Cecile

A1 - Li,Yun

A1 - Lyssenko,Valeriya

A1 - Mahley,Robert

A1 - Mangino,Massimo

A1 - Manning,Alisa K.

A1 - Teresa Martinez-Larrad,Maria

A1 - McAteer,Jarred B.

A1 - McCulloch,Laura J.

A1 - McPherson,Ruth

A1 - Meisinger,Christa

A1 - Melzer,David

A1 - Meyre,David

A1 - Mitchell,Braxton D.

A1 - Morken,Mario A.

A1 - Mukherjee,Sutapa

A1 - Naitza,Silvia

A1 - Narisu,Narisu

A1 - Neville,Matthew J.

A1 - Oostra,Ben A.

A1 - Orru,Marco

A1 - Pakyz,Ruth

A1 - Palmer,Colin N. A.

A1 - Paolisso,Giuseppe

A1 - Pattaro,Cristian

A1 - Pearson,Daniel

A1 - Peden,John F.

A1 - Pedersen,Nancy L.

A1 - Perola,Markus

A1 - Pfeiffer,Andreas F. H.

A1 - Pichler,Irene

A1 - Polasek,Ozren

A1 - Posthuma,Danielle

A1 - Potter,Simon C.

A1 - Pouta,Anneli

A1 - Province,Michael A.

A1 - Psaty,Bruce M.

A1 - Rathmann,Wolfgang

A1 - Rayner,Nigel W.

A1 - Rice,Kenneth

A1 - Ripatti,Samuli

A1 - Rivadeneira,Fernando

A1 - Roden,Michael

A1 - Rolandsson,Olov

A1 - Sandbaek,Annelli

A1 - Sandhu,Manjinder

A1 - Sanna,Serena

A1 - Sayer,Avan Aihie

A1 - Scheet,Paul

A1 - Scott,Laura J.

A1 - Seedorf,Udo

A1 - Sharp,Stephen J.

A1 - Shields,Beverley

A1 - Sigurosson,Gunnar

A1 - Sijbrands,Eric J. G.

A1 - Silveira,Angela

A1 - Simpson,Laila

A1 - Singleton,Andrew

A1 - Smith,Nicholas L.

A1 - Sovio,Ulla

A1 - Swift,Amy

A1 - Syddall,Holly

A1 - Syvanen,Ann-Christine

A1 - Tanaka,Toshiko

A1 - Thorand,Barbara

A1 - Tichet,Jean

A1 - Tonjes,Anke

A1 - Tuomi,Tiinamaija

A1 - Uitterlinden,Andre G.

A1 - van Dijk,Ko Willems

A1 - van Hoek,Mandy

A1 - Varma,Dhiraj

A1 - Visvikis-Siest,Sophie

A1 - Vitart,Veronique

A1 - Vogelzangs,Nicole

A1 - Waeber,Gerard

A1 - Wagner,Peter J.

A1 - Walley,Andrew

A1 - Walters,G. Bragi

A1 - Ward,Kim L.

A1 - Watkins,Hugh

A1 - Weedon,Michael N.

A1 - Wild,Sarah H.

A1 - Willemsen,Gonneke

A1 - Witteman,Jaqueline C. M.

A1 - Yarnell,John W. G.

A1 - Zeggini,Eleftheria

A1 - Zelenika,Diana

A1 - Zethelius,Bjorn

A1 - Zhai,Guangju

A1 - Zhao,Jing Hua

A1 - Zillikens,M. Carola

A1 - Borecki,Ingrid B.

A1 - Loos,Ruth J. F.

A1 - Meneton,Pierre

A1 - Magnusson,Patrik K. E.

A1 - Nathan,David M.

A1 - Williams,Gordon H.

A1 - Hattersley,Andrew T.

A1 - Silander,Kaisa

A1 - Salomaa,Veikko

A1 - Smith,George Davey

A1 - Bornstein,Stefan R.

A1 - Schwarz,Peter

A1 - Spranger,Joachim

A1 - Karpe,Fredrik

A1 - Shuldiner,Alan R.

A1 - Cooper,Cyrus

A1 - Dedoussis,George V.

A1 - Serrano-Rios,Manuel

A1 - Morris,Andrew D.

A1 - Lind,Lars

A1 - Palmer,Lyle J.

A1 - Hu,Frank B.

A1 - Franks,Paul W.

A1 - Ebrahim,Shah

A1 - Marmot,Michael

A1 - Kao,W. H. Linda

A1 - Pankow,James S.

A1 - Sampson,Michael J.

A1 - Kuusisto,Johanna

A1 - Laakso,Markku

A1 - Hansen,Torben

A1 - Pedersen,Oluf

A1 - Pramstaller,Peter Paul

A1 - Wichmann,H. Erich

A1 - Illig,Thomas

A1 - Rudan,Igor

A1 - Wright,Alan F.

A1 - Stumvoll,Michael

A1 - Campbell,Harry

A1 - Wilson,James F.

A1 - Bergman,Richard N.

A1 - Buchanan,Thomas A.

A1 - Collins,Francis S.

A1 - Mohlke,Karen L.

A1 - Tuomilehto,Jaakko

A1 - Valle,Timo T.

A1 - Altshuler,David

A1 - Rotter,Jerome I.

A1 - Siscovick,David S.

A1 - Penninx,Brenda W. J. H.

A1 - Boomsma,Dorret I.

A1 - Deloukas,Panos

A1 - Spector,Timothy D.

A1 - Frayling,Timothy M.

A1 - Ferrucci,Luigi

A1 - Kong,Augustine

A1 - Thorsteinsdottir,Unnur

A1 - Stefansson,Kari

A1 - van Duijn,Cornelia M.

A1 - Aulchenko,Yurii S.

A1 - Cao,Antonio

A1 - Scuteri,Angelo

A1 - Schlessinger,David

A1 - Uda,Manuela

A1 - Ruokonen,Aimo

A1 - Jarvelin,Marjo-Riitta

A1 - Waterworth,Dawn M.

A1 - Vollenweider,Peter

A1 - Peltonen,Leena

A1 - Mooser,Vincent

A1 - Abecasis,Goncalo R.

A1 - Wareham,Nicholas J.

A1 - Sladek,Robert

A1 - Froguel,Philippe

A1 - Watanabe,Richard M.

A1 - Meigs,James B.

A1 - Groop,Leif

A1 - Boehnke,Michael

A1 - McCarthy,Mark I.

A1 - Florez,Jose C.

A1 - Barroso,Ines

A1 - Anders Hamsten Procardis Consortiu, Global BPgen Consortium, GIANT Consortium, DIAGRAM Consortium, MAGIC Investigators

AU - Dupuis,Josee

AU - Langenberg,Claudia

AU - Prokopenko,Inga

AU - Saxena,Richa

AU - Soranzo,Nicole

AU - Jackson,Anne U.

AU - Wheeler,Eleanor

AU - Glazer,Nicole L.

AU - Bouatia-Naji,Nabila

AU - Gloyn,Anna L.

AU - Lindgren,Cecilia M.

AU - Magi,Reedik

AU - Morris,Andrew P.

AU - Randall,Joshua

AU - Johnson,Toby

AU - Elliott,Paul

AU - Rybin,Denis

AU - Thorleifsson,Gudmar

AU - Steinthorsdottir,Valgerdur

AU - Henneman,Peter

AU - Grallert,Harald

AU - Dehghan,Abbas

AU - Hottenga,Jouke Jan

AU - Franklin,Christopher S.

AU - Navarro,Pau

AU - Song,Kijoung

AU - Goel,Anuj

AU - Perry,John R. B.

AU - Egan,Josephine M.

AU - Lajunen,Taina

AU - Grarup,Niels

AU - Sparso,Thomas

AU - Doney,Alex S. F.

AU - Voight,Benjamin F.

AU - Stringham,Heather M.

AU - Li,Man

AU - Kanoni,Stavroula

AU - Shrader,Peter

AU - Cavalcanti-Proenca,Christine

AU - Kumari,Meena

AU - Qi,Lu

AU - Timpson,Nicholas J.

AU - Gieger,Christian

AU - Zabena,Carina

AU - Rocheleau,Ghislain

AU - Ingelsson,Erik

AU - An,Ping

AU - O'Connell,Jeffrey

AU - Luan,Jian'an

AU - Elliott,Amanda

AU - McCarroll,Steven A.

AU - Payne,Felicity

AU - Roccasecca,Rosa Maria

AU - Pattou,Francois

AU - Sethupathy,Praveen

AU - Ardlie,Kristin

AU - Ariyurek,Yavuz

AU - Balkau,Beverley

AU - Barter,Philip

AU - Beilby,John P.

AU - Ben-Shlomo,Yoav

AU - Benediktsson,Rafn

AU - Bennett,Amanda J.

AU - Bergmann,Sven

AU - Bochud,Murielle

AU - Boerwinkle,Eric

AU - Bonnefond,Amelie

AU - Bonnycastle,Lori L.

AU - Borch-Johnsen,Knut

AU - Boettcher,Yvonne

AU - Brunner,Eric

AU - Bumpstead,Suzannah J.

AU - Charpentier,Guillaume

AU - Chen,Yii-Der Ida

AU - Chines,Peter

AU - Clarke,Robert

AU - Coin,Lachlan J. M.

AU - Cooper,Matthew N.

AU - Cornelis,Marilyn

AU - Crawford,Gabe

AU - Crisponi,Laura

AU - Day,Ian N. M.

AU - de Geus,Eco J. C.

AU - Delplanque,Jerome

AU - Dina,Christian

AU - Erdos,Michael R.

AU - Fedson,Annette C.

AU - Fischer-Rosinsky,Antje

AU - Forouhi,Nita G.

AU - Fox,Caroline S.

AU - Frants,Rune

AU - Franzosi,Maria Grazia

AU - Galan,Pilar

AU - Goodarzi,Mark O.

AU - Graessler,Juergen

AU - Groves,Christopher J.

AU - Grundy,Scott

AU - Gwilliam,Rhian

AU - Gyllensten,Ulf

AU - Hadjadj,Samy

AU - Hallmans,Goeran

AU - Hammond,Naomi

AU - Han,Xijing

AU - Hartikainen,Anna-Liisa

AU - Hassanali,Neelam

AU - Hayward,Caroline

AU - Heath,Simon C.

AU - Hercberg,Serge

AU - Herder,Christian

AU - Hicks,Andrew A.

AU - Hillman,David R.

AU - Hingorani,Aroon D.

AU - Hofman,Albert

AU - Hui,Jennie

AU - Hung,Joe

AU - Isomaa,Bo

AU - Johnson,Paul R. V.

AU - Jorgensen,Torben

AU - Jula,Antti

AU - Kaakinen,Marika

AU - Kaprio,Jaakko

AU - Kesaniemi,Y. Antero

AU - Kivimaki,Mika

AU - Knight,Beatrice

AU - Koskinen,Seppo

AU - Kovacs,Peter

AU - Kyvik,Kirsten Ohm

AU - Lathrop,G. Mark

AU - Lawlor,Debbie A.

AU - Le Bacquer,Olivier

AU - Lecoeur,Cecile

AU - Li,Yun

AU - Lyssenko,Valeriya

AU - Mahley,Robert

AU - Mangino,Massimo

AU - Manning,Alisa K.

AU - Teresa Martinez-Larrad,Maria

AU - McAteer,Jarred B.

AU - McCulloch,Laura J.

AU - McPherson,Ruth

AU - Meisinger,Christa

AU - Melzer,David

AU - Meyre,David

AU - Mitchell,Braxton D.

AU - Morken,Mario A.

AU - Mukherjee,Sutapa

AU - Naitza,Silvia

AU - Narisu,Narisu

AU - Neville,Matthew J.

AU - Oostra,Ben A.

AU - Orru,Marco

AU - Pakyz,Ruth

AU - Palmer,Colin N. A.

AU - Paolisso,Giuseppe

AU - Pattaro,Cristian

AU - Pearson,Daniel

AU - Peden,John F.

AU - Pedersen,Nancy L.

AU - Perola,Markus

AU - Pfeiffer,Andreas F. H.

AU - Pichler,Irene

AU - Polasek,Ozren

AU - Posthuma,Danielle

AU - Potter,Simon C.

AU - Pouta,Anneli

AU - Province,Michael A.

AU - Psaty,Bruce M.

AU - Rathmann,Wolfgang

AU - Rayner,Nigel W.

AU - Rice,Kenneth

AU - Ripatti,Samuli

AU - Rivadeneira,Fernando

AU - Roden,Michael

AU - Rolandsson,Olov

AU - Sandbaek,Annelli

AU - Sandhu,Manjinder

AU - Sanna,Serena

AU - Sayer,Avan Aihie

AU - Scheet,Paul

AU - Scott,Laura J.

AU - Seedorf,Udo

AU - Sharp,Stephen J.

AU - Shields,Beverley

AU - Sigurosson,Gunnar

AU - Sijbrands,Eric J. G.

AU - Silveira,Angela

AU - Simpson,Laila

AU - Singleton,Andrew

AU - Smith,Nicholas L.

AU - Sovio,Ulla

AU - Swift,Amy

AU - Syddall,Holly

AU - Syvanen,Ann-Christine

AU - Tanaka,Toshiko

AU - Thorand,Barbara

AU - Tichet,Jean

AU - Tonjes,Anke

AU - Tuomi,Tiinamaija

AU - Uitterlinden,Andre G.

AU - van Dijk,Ko Willems

AU - van Hoek,Mandy

AU - Varma,Dhiraj

AU - Visvikis-Siest,Sophie

AU - Vitart,Veronique

AU - Vogelzangs,Nicole

AU - Waeber,Gerard

AU - Wagner,Peter J.

AU - Walley,Andrew

AU - Walters,G. Bragi

AU - Ward,Kim L.

AU - Watkins,Hugh

AU - Weedon,Michael N.

AU - Wild,Sarah H.

AU - Willemsen,Gonneke

AU - Witteman,Jaqueline C. M.

AU - Yarnell,John W. G.

AU - Zeggini,Eleftheria

AU - Zelenika,Diana

AU - Zethelius,Bjorn

AU - Zhai,Guangju

AU - Zhao,Jing Hua

AU - Zillikens,M. Carola

AU - Borecki,Ingrid B.

AU - Loos,Ruth J. F.

AU - Meneton,Pierre

AU - Magnusson,Patrik K. E.

AU - Nathan,David M.

AU - Williams,Gordon H.

AU - Hattersley,Andrew T.

AU - Silander,Kaisa

AU - Salomaa,Veikko

AU - Smith,George Davey

AU - Bornstein,Stefan R.

AU - Schwarz,Peter

AU - Spranger,Joachim

AU - Karpe,Fredrik

AU - Shuldiner,Alan R.

AU - Cooper,Cyrus

AU - Dedoussis,George V.

AU - Serrano-Rios,Manuel

AU - Morris,Andrew D.

AU - Lind,Lars

AU - Palmer,Lyle J.

AU - Hu,Frank B.

AU - Franks,Paul W.

AU - Ebrahim,Shah

AU - Marmot,Michael

AU - Kao,W. H. Linda

AU - Pankow,James S.

AU - Sampson,Michael J.

AU - Kuusisto,Johanna

AU - Laakso,Markku

AU - Hansen,Torben

AU - Pedersen,Oluf

AU - Pramstaller,Peter Paul

AU - Wichmann,H. Erich

AU - Illig,Thomas

AU - Rudan,Igor

AU - Wright,Alan F.

AU - Stumvoll,Michael

AU - Campbell,Harry

AU - Wilson,James F.

AU - Bergman,Richard N.

AU - Buchanan,Thomas A.

AU - Collins,Francis S.

AU - Mohlke,Karen L.

AU - Tuomilehto,Jaakko

AU - Valle,Timo T.

AU - Altshuler,David

AU - Rotter,Jerome I.

AU - Siscovick,David S.

AU - Penninx,Brenda W. J. H.

AU - Boomsma,Dorret I.

AU - Deloukas,Panos

AU - Spector,Timothy D.

AU - Frayling,Timothy M.

AU - Ferrucci,Luigi

AU - Kong,Augustine

AU - Thorsteinsdottir,Unnur

AU - Stefansson,Kari

AU - van Duijn,Cornelia M.

AU - Aulchenko,Yurii S.

AU - Cao,Antonio

AU - Scuteri,Angelo

AU - Schlessinger,David

AU - Uda,Manuela

AU - Ruokonen,Aimo

AU - Jarvelin,Marjo-Riitta

AU - Waterworth,Dawn M.

AU - Vollenweider,Peter

AU - Peltonen,Leena

AU - Mooser,Vincent

AU - Abecasis,Goncalo R.

AU - Wareham,Nicholas J.

AU - Sladek,Robert

AU - Froguel,Philippe

AU - Watanabe,Richard M.

AU - Meigs,James B.

AU - Groop,Leif

AU - Boehnke,Michael

AU - McCarthy,Mark I.

AU - Florez,Jose C.

AU - Barroso,Ines

AU - Anders Hamsten Procardis Consortiu, Global BPgen Consortium, GIANT Consortium, DIAGRAM Consortium, MAGIC Investigators

PY - 2010/2

Y1 - 2010/2

N2 - <p>Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.</p>

AB - <p>Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.</p>

KW - GENOME-WIDE ASSOCIATION

KW - BETA-CELL DYSFUNCTION

KW - PLASMA-GLUCOSE

KW - INSULIN-SECRETION

KW - TRIGLYCERIDE LEVELS

KW - ESSENTIAL COMPONENTS

KW - MODEL ASSESSMENT

KW - COMMON VARIANTS

KW - CIRCADIAN CLOCK

KW - DISEASE RISK

U2 - 10.1038/ng.520

DO - 10.1038/ng.520

M1 - Article

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 2

VL - 42

SP - 105

EP - 116

ER -

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