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New vistas for treatment of obesity and diabetes?

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New vistas for treatment of obesity and diabetes? : Endocannabinoid signalling and metabolism in the modulation of energy balance. / Lipina, C.; Rastedt, W.; Irving, A.J.; Hundal, H.S.

In: BioEssays, Vol. 34, No. 8, 01.08.2012, p. 681-691.

Research output: Contribution to journalArticle

Harvard

Lipina, C, Rastedt, W, Irving, AJ & Hundal, HS 2012, 'New vistas for treatment of obesity and diabetes?: Endocannabinoid signalling and metabolism in the modulation of energy balance' BioEssays, vol 34, no. 8, pp. 681-691., 10.1002/bies.201200031

APA

Lipina, C., Rastedt, W., Irving, A. J., & Hundal, H. S. (2012). New vistas for treatment of obesity and diabetes?: Endocannabinoid signalling and metabolism in the modulation of energy balance. BioEssays, 34(8), 681-691. 10.1002/bies.201200031

Vancouver

Lipina C, Rastedt W, Irving AJ, Hundal HS. New vistas for treatment of obesity and diabetes?: Endocannabinoid signalling and metabolism in the modulation of energy balance. BioEssays. 2012 Aug 1;34(8):681-691. Available from: 10.1002/bies.201200031

Author

Lipina, C.; Rastedt, W.; Irving, A.J.; Hundal, H.S. / New vistas for treatment of obesity and diabetes? : Endocannabinoid signalling and metabolism in the modulation of energy balance.

In: BioEssays, Vol. 34, No. 8, 01.08.2012, p. 681-691.

Research output: Contribution to journalArticle

Bibtex - Download

@article{5ead5b21817e47fc8321183d97038775,
title = "New vistas for treatment of obesity and diabetes?: Endocannabinoid signalling and metabolism in the modulation of energy balance",
author = "C. Lipina and W. Rastedt and A.J. Irving and H.S. Hundal",
year = "2012",
doi = "10.1002/bies.201200031",
volume = "34",
number = "8",
pages = "681--691",
journal = "BioEssays",
issn = "0265-9247",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - New vistas for treatment of obesity and diabetes?

T2 - Endocannabinoid signalling and metabolism in the modulation of energy balance

A1 - Lipina,C.

A1 - Rastedt,W.

A1 - Irving,A.J.

A1 - Hundal,H.S.

AU - Lipina,C.

AU - Rastedt,W.

AU - Irving,A.J.

AU - Hundal,H.S.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is associated with dyslipidemia, obesity and diabetes. Indeed, this signalling system acting through cannabinoid receptors has been shown to function both centrally and peripherally to regulate feeding behaviour as well as energy expenditure and metabolism. Consequently, modulation of these receptors can promote significant alterations in body weight and associated metabolic profile. Importantly, blocking cannabinoid receptor type 1 function has been found to prevent obesity and metabolic dysfunction in various murine models and in humans. Here we provide a detailed account of the known physiological role of the ECS in energy balance, and explore how recent studies have delivered novel insights into the potential targeting of this system as a therapeutic means for treating obesity and related metabolic disorders. The endocannabinoid system (ECS) plays an important role in the regulation of energy metabolism. Its pathological overactivation seems to be associated with dyslipidemia, obesity and diabetes. Targeting the ECS may therefore provide a therapeutic means for treating obesity and related metabolic disorders. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is associated with dyslipidemia, obesity and diabetes. Indeed, this signalling system acting through cannabinoid receptors has been shown to function both centrally and peripherally to regulate feeding behaviour as well as energy expenditure and metabolism. Consequently, modulation of these receptors can promote significant alterations in body weight and associated metabolic profile. Importantly, blocking cannabinoid receptor type 1 function has been found to prevent obesity and metabolic dysfunction in various murine models and in humans. Here we provide a detailed account of the known physiological role of the ECS in energy balance, and explore how recent studies have delivered novel insights into the potential targeting of this system as a therapeutic means for treating obesity and related metabolic disorders. The endocannabinoid system (ECS) plays an important role in the regulation of energy metabolism. Its pathological overactivation seems to be associated with dyslipidemia, obesity and diabetes. Targeting the ECS may therefore provide a therapeutic means for treating obesity and related metabolic disorders. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

UR - http://www.scopus.com/inward/record.url?scp=84863880828&partnerID=8YFLogxK

U2 - 10.1002/bies.201200031

DO - 10.1002/bies.201200031

M1 - Article

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 8

VL - 34

SP - 681

EP - 691

ER -

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