Discovery - University of Dundee - Online Publications

Library & Learning Centre

Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats

Standard

Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats. / Scerri, Charles; Stewart, Caroline A.; Balfour, David J. K.; Breen, Kieran C.

In: Neuroscience Letters, Vol. 514, No. 1, 11.04.2012, p. 22-26.

Research output: Contribution to journalArticle

Harvard

Scerri, C, Stewart, CA, Balfour, DJK & Breen, KC 2012, 'Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats' Neuroscience Letters, vol 514, no. 1, pp. 22-26.

APA

Scerri, C., Stewart, C. A., Balfour, D. J. K., & Breen, K. C. (2012). Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats. Neuroscience Letters, 514(1), 22-26doi: 10.1016/j.neulet.2012.02.042

Vancouver

Scerri C, Stewart CA, Balfour DJK, Breen KC. Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats. Neuroscience Letters. 2012 Apr 11;514(1):22-26.

Author

Scerri, Charles; Stewart, Caroline A.; Balfour, David J. K.; Breen, Kieran C. / Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats.

In: Neuroscience Letters, Vol. 514, No. 1, 11.04.2012, p. 22-26.

Research output: Contribution to journalArticle

Bibtex - Download

@article{43e3808653bf4962839616ba1c3200e2,
title = "Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats",
author = "Charles Scerri and Stewart, {Caroline A.} and Balfour, {David J. K.} and Breen, {Kieran C.}",
year = "2012",
volume = "514",
number = "1",
pages = "22--26",
journal = "Neuroscience Letters",
issn = "0304-3940",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats

A1 - Scerri,Charles

A1 - Stewart,Caroline A.

A1 - Balfour,David J. K.

A1 - Breen,Kieran C.

AU - Scerri,Charles

AU - Stewart,Caroline A.

AU - Balfour,David J. K.

AU - Breen,Kieran C.

PY - 2012/4/11

Y1 - 2012/4/11

N2 - Previous studies have shown that administration of nicotine modifies the expression and secretion of amyloid precursor protein (APP) in various cell lines. The present study investigated the extent to which chronic subcutaneous nicotine administration influences APP levels and processing in cerebral cortex, striatum and hippocampus of young and old rat brains. The results showed that constant nicotine infusion (0.25 or 4.00. mg/kg/day) increased the levels of particulate APP (APPp) but not secreted APP (APPs) in the hippocampus of young rats in vivo. This response to nicotine was not observed in the striatum or cerebral cortex of young rats or in any of the brain regions examined in old animals. Subsequent in vitro analysis demonstrated that nicotine enhanced the release of APPs from hippocampal slice preparations and that this increase was attenuated by mecamylamine, a non-selective nicotinic acetylcholine receptor (nAChR) antagonist. The in vitro effect of nicotine on APPs was age-related, being only detected from hippocampal slices derived from the young but not the older animals. These results suggest that nicotine modulates APP expression and secretion in the hippocampus and that the responses observed to the drug are age-dependent being only detected in younger rats. © 2012 Elsevier Ireland Ltd.

AB - Previous studies have shown that administration of nicotine modifies the expression and secretion of amyloid precursor protein (APP) in various cell lines. The present study investigated the extent to which chronic subcutaneous nicotine administration influences APP levels and processing in cerebral cortex, striatum and hippocampus of young and old rat brains. The results showed that constant nicotine infusion (0.25 or 4.00. mg/kg/day) increased the levels of particulate APP (APPp) but not secreted APP (APPs) in the hippocampus of young rats in vivo. This response to nicotine was not observed in the striatum or cerebral cortex of young rats or in any of the brain regions examined in old animals. Subsequent in vitro analysis demonstrated that nicotine enhanced the release of APPs from hippocampal slice preparations and that this increase was attenuated by mecamylamine, a non-selective nicotinic acetylcholine receptor (nAChR) antagonist. The in vitro effect of nicotine on APPs was age-related, being only detected from hippocampal slices derived from the young but not the older animals. These results suggest that nicotine modulates APP expression and secretion in the hippocampus and that the responses observed to the drug are age-dependent being only detected in younger rats. © 2012 Elsevier Ireland Ltd.

UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84859007700&md5=037245b4bf7665d4e74fa08633f00c4b

U2 - 10.1016/j.neulet.2012.02.042

DO - 10.1016/j.neulet.2012.02.042

M1 - Article

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

VL - 514

SP - 22

EP - 26

ER -

Documents

Library & Learning Centre

Contact | Accessibility | Policy