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Not hysteria

Not hysteria: Ovarian teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis

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  • R. Roberts
  • N.J.J. MacDougall
  • P. O'Brien
  • K. Abdelaziz
  • J. Christie
  • R. Swingler

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Original languageEnglish
JournalScottish Medical Journal
Issue number3
StatePublished - 2012


We report a case of a 33-year-old nulliparous woman who, following a short prodromal illness, experienced a series of psychiatric and behavioural symptoms. These included states of terror, insomnia, delirium, self-harm and suicidal ideation, facial dyskinesias, verbigeration, cognitive impairment, reduced responsiveness, violence and paranoia. A diagnosis of anti-N-methyl-D-aspartate (NMDAR) encephalitis was made 50 days after symptom onset. Early tumour removal is associated with an improved prognosis and a laparoscopic oophorectomy was performed following detection of a dermoid cyst. Within 24 hours of the operation there was marked improvement in cognitive function and appetite.



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