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Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

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Original languageEnglish
Pages7-9
Number of pages3
JournalJournal of Cell Biology
Journal publication date6 Oct 2008
Volume183
Issue1
DOIs
StatePublished

Abstract

A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. ( Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183: 11 - 17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities.

© 2008 Filippi and Alessi. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the fi rst six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/)

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    © 2008 Filippi and Alessi. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the fi rst six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/)

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