Nrf2 orchestrates fuel partitioning for cell proliferation. / Hayes, John D.; Ashford, Michael L. J.
In: Cell Metabolism, Vol. 16, No. 2, 2012, p. 139-141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nrf2 orchestrates fuel partitioning for cell proliferation
A1 - Hayes,John D.
A1 - Ashford,Michael L. J.
AU - Hayes,John D.
AU - Ashford,Michael L. J.
PY - 2012
Y1 - 2012
N2 - Why upregulation of the transcription factor Nrf2 increases tumor cell proliferation is unclear. Mitsuishi et al. (2012) now provide evidence that Nrf2 augments purine nucleotide synthesis, thus supporting tissue hypertrophy. This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway. © 2012 Elsevier Inc.
AB - Why upregulation of the transcription factor Nrf2 increases tumor cell proliferation is unclear. Mitsuishi et al. (2012) now provide evidence that Nrf2 augments purine nucleotide synthesis, thus supporting tissue hypertrophy. This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway. © 2012 Elsevier Inc.
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84864674743&md5=268a224433c15d519aae9c7d666d85d9
U2 - 10.1016/j.cmet.2012.07.009
DO - 10.1016/j.cmet.2012.07.009
M1 - Article
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 2
VL - 16
SP - 139
EP - 141
ER -