Optimal Placement of Origins for DNA Replication

TY - JOUR

T1 - Optimal Placement of Origins for DNA Replication

A1 - Karschau,Jens

A1 - Blow,J. Julian

A1 - de Moura,Alessandro P. S.

AU - Karschau,Jens

AU - Blow,J. Julian

AU - de Moura,Alessandro P. S.

PY - 2012/1/30

Y1 - 2012/1/30

N2 - <p>DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.</p>

AB - <p>DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.</p>

KW - SACCHAROMYCES-CEREVISIAE

KW - CHROMOSOME-REPLICATION

KW - RECOGNITION COMPLEX

KW - YEAST GENOME

KW - MODEL

KW - CHROMATIN

KW - KINETICS

KW - REVEALS

U2 - 10.1103/PhysRevLett.108.058101

DO - 10.1103/PhysRevLett.108.058101

M1 - Article

JO - Physical Review Letters

JF - Physical Review Letters

SN - 0031-9007

IS - 5

VL - 108

SP - -

ER -