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p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock

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p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. / Sabio, Guadalupe; Cerezo-Guisado, Maria I.; del Reino, Paloma; Inesta-Vaquera, Francisco A.; Rousseau, Simon; Arthur, J. Simon C.; Campbell, David G.; Centeno, Francisco; Cuenda, Ana.

In: Journal of Cell Science, Vol. 123, No. 15, 01.08.2010, p. 2596-2604.

Research output: Contribution to journalArticle

Harvard

Sabio, G, Cerezo-Guisado, MI, del Reino, P, Inesta-Vaquera, FA, Rousseau, S, Arthur, JSC, Campbell, DG, Centeno, F & Cuenda, A 2010, 'p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock' Journal of Cell Science, vol 123, no. 15, pp. 2596-2604., 10.1242/jcs.066514

APA

Sabio, G., Cerezo-Guisado, M. I., del Reino, P., Inesta-Vaquera, F. A., Rousseau, S., Arthur, J. S. C., ... Cuenda, A. (2010). p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. Journal of Cell Science, 123(15), 2596-2604. 10.1242/jcs.066514

Vancouver

Sabio G, Cerezo-Guisado MI, del Reino P, Inesta-Vaquera FA, Rousseau S, Arthur JSC et al. p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. Journal of Cell Science. 2010 Aug 1;123(15):2596-2604. Available from: 10.1242/jcs.066514

Author

Sabio, Guadalupe; Cerezo-Guisado, Maria I.; del Reino, Paloma; Inesta-Vaquera, Francisco A.; Rousseau, Simon; Arthur, J. Simon C.; Campbell, David G.; Centeno, Francisco; Cuenda, Ana / p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock.

In: Journal of Cell Science, Vol. 123, No. 15, 01.08.2010, p. 2596-2604.

Research output: Contribution to journalArticle

Bibtex - Download

@article{c3eb70f8901a461c83cb86f15df48884,
title = "p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock",
author = "Guadalupe Sabio and Cerezo-Guisado, {Maria I.} and {del Reino}, Paloma and Inesta-Vaquera, {Francisco A.} and Simon Rousseau and Arthur, {J. Simon C.} and Campbell, {David G.} and Francisco Centeno and Ana Cuenda",
year = "2010",
doi = "10.1242/jcs.066514",
volume = "123",
number = "15",
pages = "2596--2604",
journal = "Journal of Cell Science",
issn = "0021-9533",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - p38 gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock

A1 - Sabio,Guadalupe

A1 - Cerezo-Guisado,Maria I.

A1 - del Reino,Paloma

A1 - Inesta-Vaquera,Francisco A.

A1 - Rousseau,Simon

A1 - Arthur,J. Simon C.

A1 - Campbell,David G.

A1 - Centeno,Francisco

A1 - Cuenda,Ana

AU - Sabio,Guadalupe

AU - Cerezo-Guisado,Maria I.

AU - del Reino,Paloma

AU - Inesta-Vaquera,Francisco A.

AU - Rousseau,Simon

AU - Arthur,J. Simon C.

AU - Campbell,David G.

AU - Centeno,Francisco

AU - Cuenda,Ana

PY - 2010/8/1

Y1 - 2010/8/1

N2 - <p>Activation of p38 gamma modulates the integrity of the complex formed by the human discs large protein (hDlg) with cytoskeletal proteins, which is important for cell adaptation to changes in environmental osmolarity. Here we report that, in response to hyperosmotic stress, p38 gamma also regulates formation of complexes between hDlg and the nuclear protein polypyrimidine tract-binding protein-associated-splicing factor (PSF). Following osmotic shock, p38 gamma in the cell nucleus increases its association with nuclear hDlg, thereby causing dissociation of hDlg-PSF complexes. Moreover, hDlg and PSF bind different RNAs; in response to osmotic shock, p38 gamma causes hDlg-PSF and hDlg-RNA dissociation independently of its kinase activity. These findings identify a novel nuclear complex and suggest a previously unreported function of p38 gamma, which is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment.</p>

AB - <p>Activation of p38 gamma modulates the integrity of the complex formed by the human discs large protein (hDlg) with cytoskeletal proteins, which is important for cell adaptation to changes in environmental osmolarity. Here we report that, in response to hyperosmotic stress, p38 gamma also regulates formation of complexes between hDlg and the nuclear protein polypyrimidine tract-binding protein-associated-splicing factor (PSF). Following osmotic shock, p38 gamma in the cell nucleus increases its association with nuclear hDlg, thereby causing dissociation of hDlg-PSF complexes. Moreover, hDlg and PSF bind different RNAs; in response to osmotic shock, p38 gamma causes hDlg-PSF and hDlg-RNA dissociation independently of its kinase activity. These findings identify a novel nuclear complex and suggest a previously unreported function of p38 gamma, which is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment.</p>

U2 - 10.1242/jcs.066514

DO - 10.1242/jcs.066514

M1 - Article

JO - Journal of Cell Science

JF - Journal of Cell Science

SN - 0021-9533

IS - 15

VL - 123

SP - 2596

EP - 2604

ER -

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