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P53 response to ultrasound

P53 response to ultrasound: preliminary observations in MCF7 human breast cancer cells

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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  • Janis M. Burns
  • Paul A. Campbell

Research units


Original languageEnglish
Title of host publication10th International Symposium on Therapeutic Ultrasound (ISTU 2010)
EditorsYoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar
Place of PublicationMelville
PublisherAmerican Institute of Physics
Number of pages6
ISBN (Print)9780735409170
StatePublished - 2011
Event10th International Symposium on Therapeutic Ultrasound - Tokyo, Japan

Publication series

NameAIP conference proceedings
PublisherAmerican Institute of Physics


Conference10th International Symposium on Therapeutic Ultrasound
Abbreviated titleISTU 2010
Internet address


Mutated p53 can be found in approximately half of all human cancers. Strategies which seek to restore, or at least exercise a level of external control over, p53 functionality are thus potentially useful as adjuncts to therapy. Here, we report our preliminary measurements in this area, and demonstrate that short-burst pulsed ultrasound can indeed affect p53 activity. Specifically, we have observed that expression of the p53 protein can be regulated in the period immediately following low intensity short pulse (millisecond) ultrasound exposure, and that altered activity levels return to basal levels over a 24 hour period post-insonation.

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