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Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

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Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant. / Palmer, Colin N.A.; Maglio, Cristina; Pirazzi, Carlo; Burza, Maria Antonella; Adiels, Martin; Burch, Lindsay; Donnelly, Louise A.; Colhoun, Helen; Doney, Alexander S.; Dillon, John F.; Pearson, Ewan R.; McCarthy, Mark ; Hattersley, Andrew T.; Frayling, Tim; Morris, Andrew D.; Peltonen, Markku; Svensson, Per-Arne; Jacobson, Peter; Borén, Jan; Sjöström, Lars; Carlsson, Lena M. S.; Romeo, Stefano.

In: PLoS ONE, Vol. 7, No. 6, e39362, 2012.

Research output: Contribution to journalArticle

Harvard

Palmer, CNA, Maglio, C, Pirazzi, C, Burza, MA, Adiels, M, Burch, L, Donnelly, LA, Colhoun, H, Doney, AS, Dillon, JF, Pearson, ER, McCarthy, M, Hattersley, AT, Frayling, T, Morris, AD, Peltonen, M, Svensson, P-A, Jacobson, P, Borén, J, Sjöström, L, Carlsson, LMS & Romeo, S 2012, 'Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant' PLoS ONE, vol 7, no. 6, e39362., 10.1371/journal.pone.0039362

APA

Palmer, C. N. A., Maglio, C., Pirazzi, C., Burza, M. A., Adiels, M., Burch, L., ... Romeo, S. (2012). Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant. PLoS ONE, 7(6), [e39362]. 10.1371/journal.pone.0039362

Vancouver

Palmer CNA, Maglio C, Pirazzi C, Burza MA, Adiels M, Burch L et al. Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant. PLoS ONE. 2012;7(6). e39362. Available from: 10.1371/journal.pone.0039362

Author

Palmer, Colin N.A.; Maglio, Cristina; Pirazzi, Carlo; Burza, Maria Antonella; Adiels, Martin; Burch, Lindsay; Donnelly, Louise A.; Colhoun, Helen; Doney, Alexander S.; Dillon, John F.; Pearson, Ewan R.; McCarthy, Mark ; Hattersley, Andrew T.; Frayling, Tim; Morris, Andrew D.; Peltonen, Markku; Svensson, Per-Arne; Jacobson, Peter; Borén, Jan; Sjöström, Lars; Carlsson, Lena M. S.; Romeo, Stefano / Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.

In: PLoS ONE, Vol. 7, No. 6, e39362, 2012.

Research output: Contribution to journalArticle

Bibtex - Download

@article{7150eab2c1c5498bb35b1e5d9df62274,
title = "Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant",
author = "Palmer, {Colin N.A.} and Cristina Maglio and Carlo Pirazzi and Burza, {Maria Antonella} and Martin Adiels and Lindsay Burch and Donnelly, {Louise A.} and Helen Colhoun and Doney, {Alexander S.} and Dillon, {John F.} and Pearson, {Ewan R.} and Mark McCarthy and Hattersley, {Andrew T.} and Tim Frayling and Morris, {Andrew D.} and Markku Peltonen and Per-Arne Svensson and Peter Jacobson and Jan Borén and Lars Sjöström and Carlsson, {Lena M. S.} and Stefano Romeo",
year = "2012",
doi = "10.1371/journal.pone.0039362",
volume = "7",
number = "6",
journal = "PLoS ONE",
issn = "1932-6203",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

A1 - Palmer,Colin N.A.

A1 - Maglio,Cristina

A1 - Pirazzi,Carlo

A1 - Burza,Maria Antonella

A1 - Adiels,Martin

A1 - Burch,Lindsay

A1 - Donnelly,Louise A.

A1 - Colhoun,Helen

A1 - Doney,Alexander S.

A1 - Dillon,John F.

A1 - Pearson,Ewan R.

A1 - McCarthy,Mark

A1 - Hattersley,Andrew T.

A1 - Frayling,Tim

A1 - Morris,Andrew D.

A1 - Peltonen,Markku

A1 - Svensson,Per-Arne

A1 - Jacobson,Peter

A1 - Borén,Jan

A1 - Sjöström,Lars

A1 - Carlsson,Lena M. S.

A1 - Romeo,Stefano

AU - Palmer,Colin N.A.

AU - Maglio,Cristina

AU - Pirazzi,Carlo

AU - Burza,Maria Antonella

AU - Adiels,Martin

AU - Burch,Lindsay

AU - Donnelly,Louise A.

AU - Colhoun,Helen

AU - Doney,Alexander S.

AU - Dillon,John F.

AU - Pearson,Ewan R.

AU - McCarthy,Mark

AU - Hattersley,Andrew T.

AU - Frayling,Tim

AU - Morris,Andrew D.

AU - Peltonen,Markku

AU - Svensson,Per-Arne

AU - Jacobson,Peter

AU - Borén,Jan

AU - Sjöström,Lars

AU - Carlsson,Lena M. S.

AU - Romeo,Stefano

PY - 2012

Y1 - 2012

N2 - Background: Obesity is highly associated with elevated serum triglycerides, hepatic steatosis and type 2 diabetes (T2D). The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis. No association between PNPLA3 I148M genotype and T2D in Europeans has been reported. Aim of this study is to examine the relationship between PNPLA3 I148M genotypes and serum triglycerides, insulin resistance and T2D susceptibility by testing a gene-environment interaction model with severe obesity. Methods and Findings: PNPLA3 I148M was genotyped in a large obese cohort, the SOS study (n = 3,473) and in the Go-DARTS (n = 15,448), a T2D case-control study. Metabolic parameters were examined across the PNPLA3 I148M genotypes in participants of the SOS study at baseline and at 2- and 10-year follow up after bariatric surgery or conventional therapy. The associations with metabolic parameters were validated in the Go-DARTS study. Serum triglycerides were found to be lower in the PNPLA3 148M carriers from the SOS study at baseline and from the Go-DARTS T2D cohort. An increased risk for T2D conferred by the 148M allele was found in the SOS study (O.R. 1.09, 95% C.I. 1.01-1.39, P = 0.040) and in severely obese individuals in the Go-DARTS study (O.R. 1.37, 95% C.I. 1.13-1.66, P = 0.001). The 148M allele was no longer associated with insulin resistance or T2D after bariatric surgery in the SOS study and no association with the 148M allele was observed in the less obese (BMI

AB - Background: Obesity is highly associated with elevated serum triglycerides, hepatic steatosis and type 2 diabetes (T2D). The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis. No association between PNPLA3 I148M genotype and T2D in Europeans has been reported. Aim of this study is to examine the relationship between PNPLA3 I148M genotypes and serum triglycerides, insulin resistance and T2D susceptibility by testing a gene-environment interaction model with severe obesity. Methods and Findings: PNPLA3 I148M was genotyped in a large obese cohort, the SOS study (n = 3,473) and in the Go-DARTS (n = 15,448), a T2D case-control study. Metabolic parameters were examined across the PNPLA3 I148M genotypes in participants of the SOS study at baseline and at 2- and 10-year follow up after bariatric surgery or conventional therapy. The associations with metabolic parameters were validated in the Go-DARTS study. Serum triglycerides were found to be lower in the PNPLA3 148M carriers from the SOS study at baseline and from the Go-DARTS T2D cohort. An increased risk for T2D conferred by the 148M allele was found in the SOS study (O.R. 1.09, 95% C.I. 1.01-1.39, P = 0.040) and in severely obese individuals in the Go-DARTS study (O.R. 1.37, 95% C.I. 1.13-1.66, P = 0.001). The 148M allele was no longer associated with insulin resistance or T2D after bariatric surgery in the SOS study and no association with the 148M allele was observed in the less obese (BMI

UR - http://www.scopus.com/inward/record.url?scp=84862491622&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0039362

DO - 10.1371/journal.pone.0039362

M1 - Article

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 6

VL - 7

ER -

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