Discovery - University of Dundee - Online Publications

Library & Learning Centre

Paraspeckles

Paraspeckles

Research output: Contribution to journalArticle

View graph of relations

Authors

  • Archa H. Fox
  • Angus I. Lamond

Research units

Info

Original languageEnglish
???articleNumber???a000687
Pages-
Number of pages14
JournalCold Spring Harbor Perspectives in Biology
Journal publication dateJul 2010
Journal number7
Volume2
DOIs
StatePublished

Abstract

Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.

Documents

Library & Learning Centre

Contact | Accessibility | Policy