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Peak cardiac power output, measured noninvasively, is a powerful predictor of outcome in chronic heart failure

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Peak cardiac power output, measured noninvasively, is a powerful predictor of outcome in chronic heart failure. / Lang, Chim C.; Karlin, Paula; Haythe, Jennifer; Lim, Tiong K.; Mancini, Donna M. (Lead / Corresponding author).

In: Circulation: Heart Failure, Vol. 2, No. 1, 01.2009, p. 33-38.

Research output: Contribution to journalArticle

Harvard

Lang, CC, Karlin, P, Haythe, J, Lim, TK & Mancini, DM 2009, 'Peak cardiac power output, measured noninvasively, is a powerful predictor of outcome in chronic heart failure' Circulation: Heart Failure, vol 2, no. 1, pp. 33-38.

APA

Lang, C. C., Karlin, P., Haythe, J., Lim, T. K., & Mancini, D. M. (2009). Peak cardiac power output, measured noninvasively, is a powerful predictor of outcome in chronic heart failure. Circulation: Heart Failure, 2(1), 33-38doi: 10.1161/CIRCHEARTFAILURE.108.798611

Vancouver

Lang CC, Karlin P, Haythe J, Lim TK, Mancini DM. Peak cardiac power output, measured noninvasively, is a powerful predictor of outcome in chronic heart failure. Circulation: Heart Failure. 2009 Jan;2(1):33-38.

Author

Lang, Chim C.; Karlin, Paula; Haythe, Jennifer; Lim, Tiong K.; Mancini, Donna M. (Lead / Corresponding author) / Peak cardiac power output, measured noninvasively, is a powerful predictor of outcome in chronic heart failure.

In: Circulation: Heart Failure, Vol. 2, No. 1, 01.2009, p. 33-38.

Research output: Contribution to journalArticle

Bibtex - Download

@article{1136ebf47095445088693eeba601b6ff,
title = "Peak cardiac power output, measured noninvasively, is a powerful predictor of outcome in chronic heart failure",
author = "Lang, {Chim C.} and Paula Karlin and Jennifer Haythe and Lim, {Tiong K.} and Mancini, {Donna M.}",
year = "2009",
volume = "2",
number = "1",
pages = "33--38",
journal = "Circulation: Heart Failure",
issn = "1941-3289",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Peak cardiac power output, measured noninvasively, is a powerful predictor of outcome in chronic heart failure

A1 - Lang,Chim C.

A1 - Karlin,Paula

A1 - Haythe,Jennifer

A1 - Lim,Tiong K.

A1 - Mancini,Donna M.

AU - Lang,Chim C.

AU - Karlin,Paula

AU - Haythe,Jennifer

AU - Lim,Tiong K.

AU - Mancini,Donna M.

PY - 2009/1

Y1 - 2009/1

N2 - <p>Background-The cardiac output (CO) response to exercise and other invasively derived hemodynamic variables has beeh variably described to provide better prognostication than peak Vo(2) in patients with chronic heart failure. Using noninvasive measurements of CO during exercise, we compared the prognostic value of peak CO and cardiac power to peak Vo(2) in chronic heart failure patients.</p><p>Method and Results-One hundred seventy-one consecutive patients with chronic heart failure underwent symptom limited bicycle exercise with noninvasive estimation Of CO using an inert gas rebreathing method. An accurate measure of peak CO was obtained in 148 patients (85% of patients; mean age, 53 +/- 14 years; 80% male; left ventricular ejection fraction, 24 +/- 12%; ischemic etiology, 34%). Peak cardiac power was derived from the product of the peak mean arterial blood pressure and CO divided by 451. End points consisted of death, urgent heart transplant, or left ventricular assist device implantation. Duration of follow-up averaged 337 +/- 252 days (median, 295 days). Univariate and multivariate analysis were performed. The variables analyzed included peak Vo(2) peak CO, peak cardiac power, VE/VCO2 slope, and Vo(2) at anaerobic threshold. Event-free survival for the entire cohort was 83% with 5 deaths, 4 left ventricular assist device implants, and 16 urgent transplants. Peak Vo(2) was 12.9 +/- 4.5 mL/kg per min, and peak cardiac power was 1.7 +/- 0.9 W. Peak Vo(2), peak CO, peak cardiac power, VE/VCO2 slope, and Vo(2) at anaerobic threshold were predictive of outcome on univariate analysis. On multivariate analysis, peak cardiac power and peak CO were predictive of outcome with peak cardiac power being the most powerful independent predictor of outcome (P=0.01).</p><p>Conclusions-Peak cardiac power, measured noninvasively, is an independent predictor Of Outcome that can enhance the prognostic power of peak Vo(2) in the evaluation of patients with heart failure. (Circ Heart Fail. 2009;2:33-38.)</p>

AB - <p>Background-The cardiac output (CO) response to exercise and other invasively derived hemodynamic variables has beeh variably described to provide better prognostication than peak Vo(2) in patients with chronic heart failure. Using noninvasive measurements of CO during exercise, we compared the prognostic value of peak CO and cardiac power to peak Vo(2) in chronic heart failure patients.</p><p>Method and Results-One hundred seventy-one consecutive patients with chronic heart failure underwent symptom limited bicycle exercise with noninvasive estimation Of CO using an inert gas rebreathing method. An accurate measure of peak CO was obtained in 148 patients (85% of patients; mean age, 53 +/- 14 years; 80% male; left ventricular ejection fraction, 24 +/- 12%; ischemic etiology, 34%). Peak cardiac power was derived from the product of the peak mean arterial blood pressure and CO divided by 451. End points consisted of death, urgent heart transplant, or left ventricular assist device implantation. Duration of follow-up averaged 337 +/- 252 days (median, 295 days). Univariate and multivariate analysis were performed. The variables analyzed included peak Vo(2) peak CO, peak cardiac power, VE/VCO2 slope, and Vo(2) at anaerobic threshold. Event-free survival for the entire cohort was 83% with 5 deaths, 4 left ventricular assist device implants, and 16 urgent transplants. Peak Vo(2) was 12.9 +/- 4.5 mL/kg per min, and peak cardiac power was 1.7 +/- 0.9 W. Peak Vo(2), peak CO, peak cardiac power, VE/VCO2 slope, and Vo(2) at anaerobic threshold were predictive of outcome on univariate analysis. On multivariate analysis, peak cardiac power and peak CO were predictive of outcome with peak cardiac power being the most powerful independent predictor of outcome (P=0.01).</p><p>Conclusions-Peak cardiac power, measured noninvasively, is an independent predictor Of Outcome that can enhance the prognostic power of peak Vo(2) in the evaluation of patients with heart failure. (Circ Heart Fail. 2009;2:33-38.)</p>

KW - Chronic heart failure

KW - Cardiac transplantation

KW - Peak Vo(2)

KW - Cardiac output

KW - Exercise

KW - Exercise oxygen consumption

KW - Ambulatory patients

KW - Hemodynamic variables

KW - Risk stratification

KW - Transplantation

KW - Candidates

KW - Tool

KW - Selection

KW - Capacity

KW - Survival

U2 - 10.1161/CIRCHEARTFAILURE.108.798611

DO - 10.1161/CIRCHEARTFAILURE.108.798611

M1 - Article

JO - Circulation: Heart Failure

JF - Circulation: Heart Failure

SN - 1941-3289

IS - 1

VL - 2

SP - 33

EP - 38

ER -

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