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Phosphatases in SMAD regulation

Phosphatases in SMAD regulation

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Authors

  • D.L. Bruce
  • G.P. Sapkota

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Info

Original languageEnglish
Pages1897-1905
Number of pages9
JournalFEBS Letters
Journal publication date4 Jul 2012
Journal number14
Volume586
DOIs
StatePublished

Abstract

SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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