Phosphatases in SMAD regulation
Research output: Contribution to journal › Article
| Original language | English |
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| Number of pages | 9 |
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| Pages | 1897-1905 |
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| Journal | FEBS Letters |
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| Journal publication date | 4-Jul-2012 |
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| Journal number | 14 |
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| Volume | 586 |
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| DOIs | |
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| State | Published |
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SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.