TY  - JOUR
T1  - Phosphatases in SMAD regulation
A1  - Bruce,D.L.
A1  - Sapkota,G.P.
AU  - Bruce,D.L.
AU  - Sapkota,G.P.
PY  - 2012/7/4
Y1  - 2012/7/4
N2  - SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
AB  - SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
UR  - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84862759403&md5=18f0038f3673d32e7254c0e048b7e91e
U2  - 10.1016/j.febslet.2012.02.001
DO  - 10.1016/j.febslet.2012.02.001
M1  - Article
JO  - FEBS Letters
JF  - FEBS Letters
SN  - 0014-5793
IS  - 14
VL  - 586
SP  - 1897
EP  - 1905
ER  -