Phosphatases in SMAD regulation. / Bruce, D.L.; Sapkota, G.P.
In: FEBS Letters, Vol. 586, No. 14, 04.07.2012, p. 1897-1905.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phosphatases in SMAD regulation
A1 - Bruce,D.L.
A1 - Sapkota,G.P.
AU - Bruce,D.L.
AU - Sapkota,G.P.
PY - 2012/7/4
Y1 - 2012/7/4
N2 - SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
AB - SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84862759403&md5=18f0038f3673d32e7254c0e048b7e91e
U2 - 10.1016/j.febslet.2012.02.001
DO - 10.1016/j.febslet.2012.02.001
M1 - Article
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 14
VL - 586
SP - 1897
EP - 1905
ER -