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Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus

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Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. / Azzam, Ramzi; Chen, Susan L.; Shou, Wenying; Mah, Angie S.; Alexandru, Gabriela; Nasmyth, Kim; Annan, Roland S.; Carr, Steven A.; Deshaies, Raymond J.

In: Science, Vol. 305, No. 5683, 2004, p. 516-519.

Research output: Contribution to journalArticle

Harvard

Azzam, R, Chen, SL, Shou, W, Mah, AS, Alexandru, G, Nasmyth, K, Annan, RS, Carr, SA & Deshaies, RJ 2004, 'Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus' Science, vol 305, no. 5683, pp. 516-519., 10.1126/science.1099402

APA

Azzam, R., Chen, S. L., Shou, W., Mah, A. S., Alexandru, G., Nasmyth, K., ... Deshaies, R. J. (2004). Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science, 305(5683), 516-519. 10.1126/science.1099402

Vancouver

Azzam R, Chen SL, Shou W, Mah AS, Alexandru G, Nasmyth K et al. Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science. 2004;305(5683):516-519. Available from: 10.1126/science.1099402

Author

Azzam, Ramzi; Chen, Susan L.; Shou, Wenying; Mah, Angie S.; Alexandru, Gabriela; Nasmyth, Kim; Annan, Roland S.; Carr, Steven A.; Deshaies, Raymond J. / Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.

In: Science, Vol. 305, No. 5683, 2004, p. 516-519.

Research output: Contribution to journalArticle

Bibtex - Download

@article{a2f8817069fb434095be019efc401d8a,
title = "Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus",
author = "Ramzi Azzam and Chen, {Susan L.} and Wenying Shou and Mah, {Angie S.} and Gabriela Alexandru and Kim Nasmyth and Annan, {Roland S.} and Carr, {Steven A.} and Deshaies, {Raymond J.}",
year = "2004",
doi = "10.1126/science.1099402",
volume = "305",
number = "5683",
pages = "516--519",
journal = "Science",
issn = "0036-8075",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus

A1 - Azzam,Ramzi

A1 - Chen,Susan L.

A1 - Shou,Wenying

A1 - Mah,Angie S.

A1 - Alexandru,Gabriela

A1 - Nasmyth,Kim

A1 - Annan,Roland S.

A1 - Carr,Steven A.

A1 - Deshaies,Raymond J.

AU - Azzam,Ramzi

AU - Chen,Susan L.

AU - Shou,Wenying

AU - Mah,Angie S.

AU - Alexandru,Gabriela

AU - Nasmyth,Kim

AU - Annan,Roland S.

AU - Carr,Steven A.

AU - Deshaies,Raymond J.

PY - 2004

Y1 - 2004

N2 - <p>Budding yeast protein phosphatase Cdc14 is sequestered in the nucleolus in an inactive state during interphase by the anchor protein Net1. Upon entry into anaphase, the Cdc14 early anaphase release ( FEAR) network initiates dispersal of active Cdc14 throughout the cell. We report that the FEAR network promotes phosphorylation of Net1 by cyclin-dependent kinase (Cdk) complexed with cyclin B1 or cyclin B2. These phosphorylations appear to be required for FEAR and sustain the proper timing of late mitotic events. Thus, a regulatory circuit exists to ensure that the arbiter of the mitotic state, Cdk, sets in motion events that culminate in exit from mitosis.</p>

AB - <p>Budding yeast protein phosphatase Cdc14 is sequestered in the nucleolus in an inactive state during interphase by the anchor protein Net1. Upon entry into anaphase, the Cdc14 early anaphase release ( FEAR) network initiates dispersal of active Cdc14 throughout the cell. We report that the FEAR network promotes phosphorylation of Net1 by cyclin-dependent kinase (Cdk) complexed with cyclin B1 or cyclin B2. These phosphorylations appear to be required for FEAR and sustain the proper timing of late mitotic events. Thus, a regulatory circuit exists to ensure that the arbiter of the mitotic state, Cdk, sets in motion events that culminate in exit from mitosis.</p>

U2 - 10.1126/science.1099402

DO - 10.1126/science.1099402

M1 - Article

JO - Science

JF - Science

SN - 0036-8075

IS - 5683

VL - 305

SP - 516

EP - 519

ER -

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