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Preparation and characterisation of novel polycaprolactone-chitosan blends

Preparation and characterisation of novel polycaprolactone-chitosan blends

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Authors

  • Richard A. Rothwell
  • Mark S. Pridham
  • Gareth A. Thomson

Research units

Info

Original languageEnglish
Pages264-274
Number of pages11
JournalInternational Journal of Medical Engineering and Informatics
Journal publication dateOct 2011
Journal number3
Volume3
DOIs
StatePublished

Abstract

This research paper reports on the production of a biocompatible and biodegradable material to be used in a polymer stent used for counteracting the occurrence of anastomotic leakage following gastrointestinal surgery. Chitosan was blended with polycaprolactone in a solvent mixture of acetic acid and water. Membranes were formed with a range of 50/50%, 60/40%, 65/35%, 70/30% and 80/20% polycaprolactone/chitosan. The tensile properties of the blends were examined over a time period to access material degradation. In addition the biocompatibilities of the polycaprolactone/chitosan blends were tested for cytotoxic effect using primary tendon fibroblastic cells. This research concluded that the polycaprolactone/chitosan was non-toxic to the fibroblasts cells in-vitro. Analysis of the mechanical properties of the blends showed a range of mechanical strengths and polymer life spans. Overall, blends of 65/35%, 70/30% and 80/20% polycaprolactone/chitosan emerged as possible candidates for the production of a gastrointestinal stent. © 2011 Inderscience Enterprises Ltd.

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