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Pre-treatment plasma proteomic markers associated with survival in oesophageal cancer

Pre-treatment plasma proteomic markers associated with survival in oesophageal cancer

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Authors

  • P. Kelly
  • F. Paulin
  • D. Lamont
  • L. Baker
  • S. Clearly
  • D. Exon
  • A. Thompson

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Info

Original languageEnglish
Pages955-961
Number of pages7
JournalBritish Journal of Cancer
Journal publication date28 Feb 2012
Journal number5
Volume106
DOIs
StatePublished

Abstract

BACKGROUND: The incidence of oesophageal adenocarcinoma is increasing worldwide but survival remains poor. Neoadjuvant chemotherapy can improve survival, but prognostic and predictive biomarkers are required. This study built upon preclinical approaches to identify prognostic plasma proteomic markers in oesophageal cancer.

METHODS: Plasma samples collected before and during the treatment of oesophageal cancer and non-cancer controls were analysed by surface-enhanced laser desorption/ionisation time-of-flight (SELDI-TOF) mass spectroscopy (MS). Protein peaks were identified by MS in tryptic digests of purified fractions. Associations between peak intensities obtained in the spectra and clinical endpoints (survival, disease-free survival) were tested by univariate (Fisher's exact test) and multivariate analysis (binary logistic regression).

RESULTS: Plasma protein peaks were identified that differed significantly (P<0.05, ANOVA) between the oesophageal cancer and control groups at baseline. Three peaks, confirmed as apolipoprotein A-I, serum amyloid A and transthyretin, in baseline (pre-treatment) samples were associated by univariate and multivariate analysis with disease-free survival and overall survival.

CONCLUSION: Plasma proteins can be detected prior to treatment for oesophageal cancer that are associated with outcome and merit testing as prognostic and predictive markers of response to guide chemotherapy in oesophageal cancer. British Journal of Cancer (2012) 106, 955-961. doi:10.1038/bjc.2012.15 www.bjcancer.com Published online 31 January 2012 (C) 2012 Cancer Research UK

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