Discovery - University of Dundee - Online Publications

Library & Learning Centre

Regulation of glutamate receptor trafficking by leptin

Standard

Regulation of glutamate receptor trafficking by leptin. / Moult, Peter R.; Harvey, Jenni.

In: Biochemical Society Transactions, Vol. 37, 12.2009, p. 1364-1368.

Research output: Contribution to journalArticle

Harvard

Moult, PR & Harvey, J 2009, 'Regulation of glutamate receptor trafficking by leptin' Biochemical Society Transactions, vol 37, pp. 1364-1368.

APA

Moult, P. R., & Harvey, J. (2009). Regulation of glutamate receptor trafficking by leptin. Biochemical Society Transactions, 37, 1364-1368doi: 10.1042/BST0371364

Vancouver

Moult PR, Harvey J. Regulation of glutamate receptor trafficking by leptin. Biochemical Society Transactions. 2009 Dec;37:1364-1368.

Author

Moult, Peter R.; Harvey, Jenni / Regulation of glutamate receptor trafficking by leptin.

In: Biochemical Society Transactions, Vol. 37, 12.2009, p. 1364-1368.

Research output: Contribution to journalArticle

Bibtex - Download

@article{b80171fb270a4493882b3b94d1b4dbc3,
title = "Regulation of glutamate receptor trafficking by leptin",
author = "Moult, {Peter R.} and Jenni Harvey",
year = "2009",
volume = "37",
pages = "1364--1368",
journal = "Biochemical Society Transactions",
issn = "0300-5127",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Regulation of glutamate receptor trafficking by leptin

A1 - Moult,Peter R.

A1 - Harvey,Jenni

AU - Moult,Peter R.

AU - Harvey,Jenni

PY - 2009/12

Y1 - 2009/12

N2 - <p>It is well established that leptin is a circulating hormone that enters the brain and regulates food intake and body weight via its hypothalamic actions. However, it is also known that leptin receptors are widely expressed in the CNS (central nervous system), and evidence is accumulating that leptin modulates many neuronal functions. in particular, recent studies have indicated that leptin plays an important role in the regulation of hippocampal synaptic plasticity. indeed leptin-insensitive rodents display impairments in hippocampal synaptic plasticity and defects in spatial memory tasks. We have also shown that leptin facilitates the induction of hippocampal UP (long-term potentiation) via enhancing NMDA (N-methyl-D-aspartate) receptor function and that leptin has the ability to evoke a novel form of NMDA receptor-dependent LTD (long-term depression). in addition, leptin promotes rapid alterations in hippocampal dendritic morphology and synaptic density, which are likely to contribute to the effects of this hormone on excitatory synaptic strength. Recent studies have demonstrated that trafficking of AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors is pivotal for activity-dependent hippocampal synaptic plasticity. However, little is known about how AMPA receptor trafficking processes are regulated by hormonal systems. In the present paper, we discuss evidence that leptin rapidly alters the trafficking of AMPA receptors to and away from hippocampal CA1 synapses. The impact of these leptin-driven changes on hippocampal excitatory synaptic function are discussed.</p>

AB - <p>It is well established that leptin is a circulating hormone that enters the brain and regulates food intake and body weight via its hypothalamic actions. However, it is also known that leptin receptors are widely expressed in the CNS (central nervous system), and evidence is accumulating that leptin modulates many neuronal functions. in particular, recent studies have indicated that leptin plays an important role in the regulation of hippocampal synaptic plasticity. indeed leptin-insensitive rodents display impairments in hippocampal synaptic plasticity and defects in spatial memory tasks. We have also shown that leptin facilitates the induction of hippocampal UP (long-term potentiation) via enhancing NMDA (N-methyl-D-aspartate) receptor function and that leptin has the ability to evoke a novel form of NMDA receptor-dependent LTD (long-term depression). in addition, leptin promotes rapid alterations in hippocampal dendritic morphology and synaptic density, which are likely to contribute to the effects of this hormone on excitatory synaptic strength. Recent studies have demonstrated that trafficking of AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors is pivotal for activity-dependent hippocampal synaptic plasticity. However, little is known about how AMPA receptor trafficking processes are regulated by hormonal systems. In the present paper, we discuss evidence that leptin rapidly alters the trafficking of AMPA receptors to and away from hippocampal CA1 synapses. The impact of these leptin-driven changes on hippocampal excitatory synaptic function are discussed.</p>

KW - alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPA receptor)

KW - hippocampus

KW - leptin

KW - N-methyl-n-aspartate receptor (NMDA receptor)

KW - synaptic plasticity

KW - trafficking

KW - LONG-TERM POTENTIATION

KW - HIPPOCAMPAL SYNAPTIC PLASTICITY

KW - GLUR2-LACKING AMPA RECEPTORS

KW - NMDA RECEPTORS

KW - MESSENGER-RNA

KW - CA1 SYNAPSES

KW - RAT-BRAIN

KW - PHOSPHORYLATION

KW - DEPOTENTIATION

KW - EXPRESSION

U2 - 10.1042/BST0371364

DO - 10.1042/BST0371364

M1 - Article

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

VL - 37

SP - 1364

EP - 1368

ER -

Documents

Library & Learning Centre

Contact | Accessibility | Policy