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Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder

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Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder. / Doyle, Christopher; Brookes, Keeley; Simpson, Jennifer; Park, Joanne; Scott, Sarah; Coghill, David R.; Hawi, Ziarah; Kirley, Aiveen; Gill, Michael; Kent, Lindsey.

In: Neuroscience Letters, Vol. 462, No. 2, 22.09.2009, p. 179-181.

Research output: Contribution to journalArticle

Harvard

Doyle, C, Brookes, K, Simpson, J, Park, J, Scott, S, Coghill, DR, Hawi, Z, Kirley, A, Gill, M & Kent, L 2009, 'Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder' Neuroscience Letters, vol 462, no. 2, pp. 179-181.

APA

Doyle, C., Brookes, K., Simpson, J., Park, J., Scott, S., Coghill, D. R., Hawi, Z., Kirley, A., Gill, M., & Kent, L. (2009). Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder. Neuroscience Letters, 462(2), 179-181doi: 10.1016/j.neulet.2009.06.084

Vancouver

Doyle C, Brookes K, Simpson J, Park J, Scott S, Coghill DR et al. Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder. Neuroscience Letters. 2009 Sep 22;462(2):179-181.

Author

Doyle, Christopher; Brookes, Keeley; Simpson, Jennifer; Park, Joanne; Scott, Sarah; Coghill, David R.; Hawi, Ziarah; Kirley, Aiveen; Gill, Michael; Kent, Lindsey / Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder.

In: Neuroscience Letters, Vol. 462, No. 2, 22.09.2009, p. 179-181.

Research output: Contribution to journalArticle

Bibtex - Download

@article{d6f6427601444849b7526192a48210a5,
title = "Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder",
author = "Christopher Doyle and Keeley Brookes and Jennifer Simpson and Joanne Park and Sarah Scott and Coghill, {David R.} and Ziarah Hawi and Aiveen Kirley and Michael Gill and Lindsey Kent",
year = "2009",
volume = "462",
number = "2",
pages = "179--181",
journal = "Neuroscience Letters",
issn = "0304-3940",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder

A1 - Doyle,Christopher

A1 - Brookes,Keeley

A1 - Simpson,Jennifer

A1 - Park,Joanne

A1 - Scott,Sarah

A1 - Coghill,David R.

A1 - Hawi,Ziarah

A1 - Kirley,Aiveen

A1 - Gill,Michael

A1 - Kent,Lindsey

AU - Doyle,Christopher

AU - Brookes,Keeley

AU - Simpson,Jennifer

AU - Park,Joanne

AU - Scott,Sarah

AU - Coghill,David R.

AU - Hawi,Ziarah

AU - Kirley,Aiveen

AU - Gill,Michael

AU - Kent,Lindsey

PY - 2009/9/22

Y1 - 2009/9/22

N2 - <p>Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The current study aims to replicate recent association findings from the International Multicentre ADHD Genetics (IMAGE) project in one of the most studied genes related to ADHD, the dopamine transporter (DAT1) gene. In a family-based sample of 450 ADHD probands, three Single Nucleotide Polymorphism (SNP) markers have been genotyped using TaqMan assays. Transmission Disequilibrium Test analysis demonstrates that one of three SNP markers (rs11564750) in the 5' promoter region of the gene is significantly associated with ADHD (P=0.02). This provides further evidence that in addition to the well-known and investigated 3'UTR polymorphism associated with ADHD, there is potentially a further association signal emanating from the 5' promoter region of the gene. Further replication and functional studies are now required to fully understand the consequence of polymorphisms present at both the 5' and 3' ends of the DAT1 gene and their role in ADHD pathophysiology. (c) 2009 Elsevier Ireland Ltd. All rights reserved.</p>

AB - <p>Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The current study aims to replicate recent association findings from the International Multicentre ADHD Genetics (IMAGE) project in one of the most studied genes related to ADHD, the dopamine transporter (DAT1) gene. In a family-based sample of 450 ADHD probands, three Single Nucleotide Polymorphism (SNP) markers have been genotyped using TaqMan assays. Transmission Disequilibrium Test analysis demonstrates that one of three SNP markers (rs11564750) in the 5' promoter region of the gene is significantly associated with ADHD (P=0.02). This provides further evidence that in addition to the well-known and investigated 3'UTR polymorphism associated with ADHD, there is potentially a further association signal emanating from the 5' promoter region of the gene. Further replication and functional studies are now required to fully understand the consequence of polymorphisms present at both the 5' and 3' ends of the DAT1 gene and their role in ADHD pathophysiology. (c) 2009 Elsevier Ireland Ltd. All rights reserved.</p>

KW - ADHD

KW - DAT1

KW - Association

KW - Replication

KW - Polymorphism

KW - DEFICIT/HYPERACTIVITY DISORDER

KW - LINKAGE DISEQUILIBRIUM

KW - PRENATAL SMOKING

KW - ADHD

KW - HAPLOTYPE

KW - DAT1

KW - GENOTYPE

KW - CHILDREN

U2 - 10.1016/j.neulet.2009.06.084

DO - 10.1016/j.neulet.2009.06.084

M1 - Article

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

VL - 462

SP - 179

EP - 181

ER -

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