Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder. / Doyle, Christopher; Brookes, Keeley; Simpson, Jennifer; Park, Joanne; Scott, Sarah; Coghill, David R.; Hawi, Ziarah; Kirley, Aiveen; Gill, Michael; Kent, Lindsey.
In: Neuroscience Letters, Vol. 462, No. 2, 22.09.2009, p. 179-181.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder
A1 - Doyle,Christopher
A1 - Brookes,Keeley
A1 - Simpson,Jennifer
A1 - Park,Joanne
A1 - Scott,Sarah
A1 - Coghill,David R.
A1 - Hawi,Ziarah
A1 - Kirley,Aiveen
A1 - Gill,Michael
A1 - Kent,Lindsey
AU - Doyle,Christopher
AU - Brookes,Keeley
AU - Simpson,Jennifer
AU - Park,Joanne
AU - Scott,Sarah
AU - Coghill,David R.
AU - Hawi,Ziarah
AU - Kirley,Aiveen
AU - Gill,Michael
AU - Kent,Lindsey
PY - 2009/9/22
Y1 - 2009/9/22
N2 - <p>Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The current study aims to replicate recent association findings from the International Multicentre ADHD Genetics (IMAGE) project in one of the most studied genes related to ADHD, the dopamine transporter (DAT1) gene. In a family-based sample of 450 ADHD probands, three Single Nucleotide Polymorphism (SNP) markers have been genotyped using TaqMan assays. Transmission Disequilibrium Test analysis demonstrates that one of three SNP markers (rs11564750) in the 5' promoter region of the gene is significantly associated with ADHD (P=0.02). This provides further evidence that in addition to the well-known and investigated 3'UTR polymorphism associated with ADHD, there is potentially a further association signal emanating from the 5' promoter region of the gene. Further replication and functional studies are now required to fully understand the consequence of polymorphisms present at both the 5' and 3' ends of the DAT1 gene and their role in ADHD pathophysiology. (c) 2009 Elsevier Ireland Ltd. All rights reserved.</p>
AB - <p>Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The current study aims to replicate recent association findings from the International Multicentre ADHD Genetics (IMAGE) project in one of the most studied genes related to ADHD, the dopamine transporter (DAT1) gene. In a family-based sample of 450 ADHD probands, three Single Nucleotide Polymorphism (SNP) markers have been genotyped using TaqMan assays. Transmission Disequilibrium Test analysis demonstrates that one of three SNP markers (rs11564750) in the 5' promoter region of the gene is significantly associated with ADHD (P=0.02). This provides further evidence that in addition to the well-known and investigated 3'UTR polymorphism associated with ADHD, there is potentially a further association signal emanating from the 5' promoter region of the gene. Further replication and functional studies are now required to fully understand the consequence of polymorphisms present at both the 5' and 3' ends of the DAT1 gene and their role in ADHD pathophysiology. (c) 2009 Elsevier Ireland Ltd. All rights reserved.</p>
KW - ADHD
KW - DAT1
KW - Association
KW - Replication
KW - Polymorphism
KW - DEFICIT/HYPERACTIVITY DISORDER
KW - LINKAGE DISEQUILIBRIUM
KW - PRENATAL SMOKING
KW - ADHD
KW - HAPLOTYPE
KW - DAT1
KW - GENOTYPE
KW - CHILDREN
U2 - 10.1016/j.neulet.2009.06.084
DO - 10.1016/j.neulet.2009.06.084
M1 - Article
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
VL - 462
SP - 179
EP - 181
ER -