Discovery - University of Dundee - Online Publications

Library & Learning Centre

Risk of hospitalization and death following prostate biopsy in Scotland

Risk of hospitalization and death following prostate biopsy in Scotland

Research output: Contribution to journalArticle

View graph of relations


  • David H. Brewster
  • Colin M. Fischbacher
  • J. Nolan
  • S. Nowell
  • D. Redpath
  • Ghulam Nabi

Research units


Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalPublic Health
Early online date31 Oct 2016
StatePublished - Jan 2017


Objective: To investigate the risk of hospitalization and death following prostate biopsy.

Study design: Retrospective cohort study.

Methods: Our study population comprised 10,285 patients with a record of first ever prostate biopsy between 2009 and 2013 on computerized acute hospital discharge or outpatient records covering Scotland. Using the general population as a comparison group, expected numbers of admissions/deaths were derived by applying age-, sex-, deprivation category-, and calendar year-specific rates of hospital admissions/deaths to the study population. Indirectly standardized hospital admission ratios (SHRs) and mortality ratios (SMRs) were calculated by dividing the observed numbers of admissions/deaths by expected numbers.

Results: Compared with background rates, patients were more likely to be admitted to hospital within 30 days (SHR 2.7; 95% confidence interval 2.4, 2.9) and 120 days (SHR 4.0; 3.8, 4.1) of biopsy. Patients with prior co-morbidity had higher SHRs. The risk of death within 30 days of biopsy was not increased significantly (SMR 1.6; 0.9, 2.7), but within 120 days, the risk of death was significantly higher than expected (SMR 1.9; 1.5, 2.4). The risk of death increased with age and tended to be higher among patients with prior co-morbidity. Overall risks of hospitalization and of death up to 120 days were increased both in men diagnosed and those not diagnosed with prostate cancer.

Conclusions: Higher rates of adverse events in older patients and patients with prior co-morbidity emphasizes the need for careful patient selection for prostate biopsy and justifies ongoing efforts to minimize the risk of complications.

Download statistics

No data available


Open Access permissions



  • Final Published Version

    Final published version, 282 KB, PDF-document

    © 2016 The Authors. Published by Elsevier Ltd on behalf of The Royal Society for Public Health. This is an open access article under the CC BY-NC-ND license (


Library & Learning Centre

Contact | Accessibility | Policy