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Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial

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Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial : study protocol for randomized controlled trial. / Newby, David E; Williams, Michelle C; Flappan, Andrew D; Forbes, John F; Hargreaves, Allister D; Leslie, Stephen J; Lewis, Steff C; McKillop, Graham; McLean, Scott; Reid, John; Spratt, James C; Uren, Neal G; van Beek, Edwin J; Boon, Nicholas A; Clark, Liz; Craig, Peter; Flather, Marcus D; McCormack, Chiara; Roditi, Giles; Timmis, Adam D; Krishan, Ashma; Donaldson, Gillian; Fotheringham, Marlene; Hall, Fiona J; Neary, Paul; Cram, Louisa; Perkins, Sarah; Taylor, Fiona; Eteiba, Hany; Rae, Alan P; Robb, Kate; Barrie, Dawn; Bissett, Kim; Dawson, Adelle; Dundas, Scot; Fogarty, Yvonne; Ramkumar, Prasad G; Houston, Graeme J; Letham, Deborah; O'Neill, Linda; Pringle, Stuart; Ritchie, Valerie; Sudarshan, Thiru; Weir-McCall, Jonathan; Cormack, Alistair; Findlay, Iain N; Hood, Stuart; Murphy, Clare; Peat, Eileen; Allen, Barbara; Bertram, Danielle; Brian, David; Cowan, Amy; Cruden, Nicholas L; Dweck, Marc R; Flint, Laura; Fyfe, Samantha; Harding, Collette; MacGillivray, Tom J; Maclachlan, David S; Macleod, Margaret; Misadraee, Saeed; Morrison, Avril; Mills, Nicholas L; Phillips, Alyson; Queripel, Laura J; Weir, Nicholas W; Bett, Fiona; Divers, Frances; Fairley, Katie; Jacob, Ashok J; Keegan, Edith; White, Tricia; Gemmil, John; Henry, Margo; McGowan, James; Dinnel, Lorraine; Francis, Marc C; Sandeman, Dennis; Yerramasu, Ajay; Morrison, Avril; Berry, Colin; Boylan, Heather; Brown, Ammani; Duffy, Karen; Frood, Alison; Johnstone, Janet; Langhan, Kirsten; Macduff, Ross; MacLeod, Martin; McGlynn, Deborah; McMillan, Nigel; Murdoch, Laura; Noble, Colin; Paterson, Victoria; Roditi, Giles; Steedman, Tracey; Tzemos, Nikolaos; Baird, Andrew; Minns, Fiona C.

In: Trials, Vol. 13, 184, 04.10.2012.

Research output: Contribution to journalArticle

Harvard

Newby, DE, Williams, MC, Flappan, AD, Forbes, JF, Hargreaves, AD, Leslie, SJ, Lewis, SC, McKillop, G, McLean, S, Reid, J, Spratt, JC, Uren, NG, van Beek, EJ, Boon, NA, Clark, L, Craig, P, Flather, MD, McCormack, C, Roditi, G, Timmis, AD, Krishan, A, Donaldson, G, Fotheringham, M, Hall, FJ, Neary, P, Cram, L, Perkins, S, Taylor, F, Eteiba, H, Rae, AP, Robb, K, Barrie, D, Bissett, K, Dawson, A, Dundas, S, Fogarty, Y, Ramkumar, PG, Houston, GJ, Letham, D, O'Neill, L, Pringle, S, Ritchie, V, Sudarshan, T, Weir-McCall, J, Cormack, A, Findlay, IN, Hood, S, Murphy, C, Peat, E, Allen, B, Bertram, D, Brian, D, Cowan, A, Cruden, NL, Dweck, MR, Flint, L, Fyfe, S, Harding, C, MacGillivray, TJ, Maclachlan, DS, Macleod, M, Misadraee, S, Morrison, A, Mills, NL, Phillips, A, Queripel, LJ, Weir, NW, Bett, F, Divers, F, Fairley, K, Jacob, AJ, Keegan, E, White, T, Gemmil, J, Henry, M, McGowan, J, Dinnel, L, Francis, MC, Sandeman, D, Yerramasu, A, Morrison, A, Berry, C, Boylan, H, Brown, A, Duffy, K, Frood, A, Johnstone, J, Langhan, K, Macduff, R, MacLeod, M, McGlynn, D, McMillan, N, Murdoch, L, Noble, C, Paterson, V, Roditi, G, Steedman, T, Tzemos, N, Baird, A & Minns, FC 2012, 'Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial' Trials, vol 13, 184.

APA

Newby, D. E., Williams, M. C., Flappan, A. D., Forbes, J. F., Hargreaves, A. D., Leslie, S. J., Lewis, S. C., McKillop, G., McLean, S., Reid, J., Spratt, J. C., Uren, N. G., van Beek, E. J., Boon, N. A., Clark, L., Craig, P., Flather, M. D., McCormack, C., Roditi, G., Timmis, A. D., Krishan, A., Donaldson, G., Fotheringham, M., Hall, F. J., Neary, P., Cram, L., Perkins, S., Taylor, F., Eteiba, H., Rae, A. P., Robb, K., Barrie, D., Bissett, K., Dawson, A., Dundas, S., Fogarty, Y., Ramkumar, P. G., Houston, G. J., Letham, D., O'Neill, L., Pringle, S., Ritchie, V., Sudarshan, T., Weir-McCall, J., Cormack, A., Findlay, I. N., Hood, S., Murphy, C., Peat, E., Allen, B., Bertram, D., Brian, D., Cowan, A., Cruden, N. L., Dweck, M. R., Flint, L., Fyfe, S., Harding, C., MacGillivray, T. J., Maclachlan, D. S., Macleod, M., Misadraee, S., Morrison, A., Mills, N. L., Phillips, A., Queripel, L. J., Weir, N. W., Bett, F., Divers, F., Fairley, K., Jacob, A. J., Keegan, E., White, T., Gemmil, J., Henry, M., McGowan, J., Dinnel, L., Francis, M. C., Sandeman, D., Yerramasu, A., Morrison, A., Berry, C., Boylan, H., Brown, A., Duffy, K., Frood, A., Johnstone, J., Langhan, K., Macduff, R., MacLeod, M., McGlynn, D., McMillan, N., Murdoch, L., Noble, C., Paterson, V., Roditi, G., Steedman, T., Tzemos, N., Baird, A., & Minns, F. C. (2012). Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial. Trials, 13, [184]doi: 10.1186/1745-6215-13-184

Vancouver

Newby DE, Williams MC, Flappan AD, Forbes JF, Hargreaves AD, Leslie SJ et al. Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial. Trials. 2012 Oct 4;13. 184.

Author

Newby, David E; Williams, Michelle C; Flappan, Andrew D; Forbes, John F; Hargreaves, Allister D; Leslie, Stephen J; Lewis, Steff C; McKillop, Graham; McLean, Scott; Reid, John; Spratt, James C; Uren, Neal G; van Beek, Edwin J; Boon, Nicholas A; Clark, Liz; Craig, Peter; Flather, Marcus D; McCormack, Chiara; Roditi, Giles; Timmis, Adam D; Krishan, Ashma; Donaldson, Gillian; Fotheringham, Marlene; Hall, Fiona J; Neary, Paul; Cram, Louisa; Perkins, Sarah; Taylor, Fiona; Eteiba, Hany; Rae, Alan P; Robb, Kate; Barrie, Dawn; Bissett, Kim; Dawson, Adelle; Dundas, Scot; Fogarty, Yvonne; Ramkumar, Prasad G; Houston, Graeme J; Letham, Deborah; O'Neill, Linda; Pringle, Stuart; Ritchie, Valerie; Sudarshan, Thiru; Weir-McCall, Jonathan; Cormack, Alistair; Findlay, Iain N; Hood, Stuart; Murphy, Clare; Peat, Eileen; Allen, Barbara; Bertram, Danielle; Brian, David; Cowan, Amy; Cruden, Nicholas L; Dweck, Marc R; Flint, Laura; Fyfe, Samantha; Harding, Collette; MacGillivray, Tom J; Maclachlan, David S; Macleod, Margaret; Misadraee, Saeed; Morrison, Avril; Mills, Nicholas L; Phillips, Alyson; Queripel, Laura J; Weir, Nicholas W; Bett, Fiona; Divers, Frances; Fairley, Katie; Jacob, Ashok J; Keegan, Edith; White, Tricia; Gemmil, John; Henry, Margo; McGowan, James; Dinnel, Lorraine; Francis, Marc C; Sandeman, Dennis; Yerramasu, Ajay; Morrison, Avril; Berry, Colin; Boylan, Heather; Brown, Ammani; Duffy, Karen; Frood, Alison; Johnstone, Janet; Langhan, Kirsten; Macduff, Ross; MacLeod, Martin; McGlynn, Deborah; McMillan, Nigel; Murdoch, Laura; Noble, Colin; Paterson, Victoria; Roditi, Giles; Steedman, Tracey; Tzemos, Nikolaos; Baird, Andrew; Minns, Fiona C / Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial : study protocol for randomized controlled trial.

In: Trials, Vol. 13, 184, 04.10.2012.

Research output: Contribution to journalArticle

Bibtex - Download

@article{6a508abf521d48ef8c7d301f83b011bd,
title = "Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial",
author = "Newby, {David E} and Williams, {Michelle C} and Flappan, {Andrew D} and Forbes, {John F} and Hargreaves, {Allister D} and Leslie, {Stephen J} and Lewis, {Steff C} and Graham McKillop and Scott McLean and John Reid and Spratt, {James C} and Uren, {Neal G} and {van Beek}, {Edwin J} and Boon, {Nicholas A} and Liz Clark and Peter Craig and Flather, {Marcus D} and Chiara McCormack and Giles Roditi and Timmis, {Adam D} and Ashma Krishan and Gillian Donaldson and Marlene Fotheringham and Hall, {Fiona J} and Paul Neary and Louisa Cram and Sarah Perkins and Fiona Taylor and Hany Eteiba and Rae, {Alan P} and Kate Robb and Dawn Barrie and Kim Bissett and Adelle Dawson and Scot Dundas and Yvonne Fogarty and Ramkumar, {Prasad G} and Houston, {Graeme J} and Deborah Letham and Linda O'Neill and Stuart Pringle and Valerie Ritchie and Thiru Sudarshan and Jonathan Weir-McCall and Alistair Cormack and Findlay, {Iain N} and Stuart Hood and Clare Murphy and Eileen Peat and Barbara Allen and Danielle Bertram and David Brian and Amy Cowan and Cruden, {Nicholas L} and Dweck, {Marc R} and Laura Flint and Samantha Fyfe and Collette Harding and MacGillivray, {Tom J} and Maclachlan, {David S} and Margaret Macleod and Saeed Misadraee and Avril Morrison and Mills, {Nicholas L} and Alyson Phillips and Queripel, {Laura J} and Weir, {Nicholas W} and Fiona Bett and Frances Divers and Katie Fairley and Jacob, {Ashok J} and Edith Keegan and Tricia White and John Gemmil and Margo Henry and James McGowan and Lorraine Dinnel and Francis, {Marc C} and Dennis Sandeman and Ajay Yerramasu and Avril Morrison and Colin Berry and Heather Boylan and Ammani Brown and Karen Duffy and Alison Frood and Janet Johnstone and Kirsten Langhan and Ross Macduff and Martin MacLeod and Deborah McGlynn and Nigel McMillan and Laura Murdoch and Colin Noble and Victoria Paterson and Giles Roditi and Tracey Steedman and Nikolaos Tzemos and Andrew Baird and Minns, {Fiona C}",
year = "2012",
volume = "13",
journal = "Trials",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial

T2 - study protocol for randomized controlled trial

A1 - Newby,David E

A1 - Williams,Michelle C

A1 - Flappan,Andrew D

A1 - Forbes,John F

A1 - Hargreaves,Allister D

A1 - Leslie,Stephen J

A1 - Lewis,Steff C

A1 - McKillop,Graham

A1 - McLean,Scott

A1 - Reid,John

A1 - Spratt,James C

A1 - Uren,Neal G

A1 - van Beek,Edwin J

A1 - Boon,Nicholas A

A1 - Clark,Liz

A1 - Craig,Peter

A1 - Flather,Marcus D

A1 - McCormack,Chiara

A1 - Roditi,Giles

A1 - Timmis,Adam D

A1 - Krishan,Ashma

A1 - Donaldson,Gillian

A1 - Fotheringham,Marlene

A1 - Hall,Fiona J

A1 - Neary,Paul

A1 - Cram,Louisa

A1 - Perkins,Sarah

A1 - Taylor,Fiona

A1 - Eteiba,Hany

A1 - Rae,Alan P

A1 - Robb,Kate

A1 - Barrie,Dawn

A1 - Bissett,Kim

A1 - Dawson,Adelle

A1 - Dundas,Scot

A1 - Fogarty,Yvonne

A1 - Ramkumar,Prasad G

A1 - Houston,Graeme J

A1 - Letham,Deborah

A1 - O'Neill,Linda

A1 - Pringle,Stuart

A1 - Ritchie,Valerie

A1 - Sudarshan,Thiru

A1 - Weir-McCall,Jonathan

A1 - Cormack,Alistair

A1 - Findlay,Iain N

A1 - Hood,Stuart

A1 - Murphy,Clare

A1 - Peat,Eileen

A1 - Allen,Barbara

A1 - Bertram,Danielle

A1 - Brian,David

A1 - Cowan,Amy

A1 - Cruden,Nicholas L

A1 - Dweck,Marc R

A1 - Flint,Laura

A1 - Fyfe,Samantha

A1 - Harding,Collette

A1 - MacGillivray,Tom J

A1 - Maclachlan,David S

A1 - Macleod,Margaret

A1 - Misadraee,Saeed

A1 - Morrison,Avril

A1 - Mills,Nicholas L

A1 - Phillips,Alyson

A1 - Queripel,Laura J

A1 - Weir,Nicholas W

A1 - Bett,Fiona

A1 - Divers,Frances

A1 - Fairley,Katie

A1 - Jacob,Ashok J

A1 - Keegan,Edith

A1 - White,Tricia

A1 - Gemmil,John

A1 - Henry,Margo

A1 - McGowan,James

A1 - Dinnel,Lorraine

A1 - Francis,Marc C

A1 - Sandeman,Dennis

A1 - Yerramasu,Ajay

A1 - Berry,Colin

A1 - Boylan,Heather

A1 - Brown,Ammani

A1 - Duffy,Karen

A1 - Frood,Alison

A1 - Johnstone,Janet

A1 - Langhan,Kirsten

A1 - Macduff,Ross

A1 - MacLeod,Martin

A1 - McGlynn,Deborah

A1 - McMillan,Nigel

A1 - Murdoch,Laura

A1 - Noble,Colin

A1 - Paterson,Victoria

A1 - Steedman,Tracey

A1 - Tzemos,Nikolaos

A1 - Baird,Andrew

A1 - Minns,Fiona C

AU - Newby,David E

AU - Williams,Michelle C

AU - Flappan,Andrew D

AU - Forbes,John F

AU - Hargreaves,Allister D

AU - Leslie,Stephen J

AU - Lewis,Steff C

AU - McKillop,Graham

AU - McLean,Scott

AU - Reid,John

AU - Spratt,James C

AU - Uren,Neal G

AU - van Beek,Edwin J

AU - Boon,Nicholas A

AU - Clark,Liz

AU - Craig,Peter

AU - Flather,Marcus D

AU - McCormack,Chiara

AU - Roditi,Giles

AU - Timmis,Adam D

AU - Krishan,Ashma

AU - Donaldson,Gillian

AU - Fotheringham,Marlene

AU - Hall,Fiona J

AU - Neary,Paul

AU - Cram,Louisa

AU - Perkins,Sarah

AU - Taylor,Fiona

AU - Eteiba,Hany

AU - Rae,Alan P

AU - Robb,Kate

AU - Barrie,Dawn

AU - Bissett,Kim

AU - Dawson,Adelle

AU - Dundas,Scot

AU - Fogarty,Yvonne

AU - Ramkumar,Prasad G

AU - Houston,Graeme J

AU - Letham,Deborah

AU - O'Neill,Linda

AU - Pringle,Stuart

AU - Ritchie,Valerie

AU - Sudarshan,Thiru

AU - Weir-McCall,Jonathan

AU - Cormack,Alistair

AU - Findlay,Iain N

AU - Hood,Stuart

AU - Murphy,Clare

AU - Peat,Eileen

AU - Allen,Barbara

AU - Bertram,Danielle

AU - Brian,David

AU - Cowan,Amy

AU - Cruden,Nicholas L

AU - Dweck,Marc R

AU - Flint,Laura

AU - Fyfe,Samantha

AU - Harding,Collette

AU - MacGillivray,Tom J

AU - Maclachlan,David S

AU - Macleod,Margaret

AU - Misadraee,Saeed

AU - Morrison,Avril

AU - Mills,Nicholas L

AU - Phillips,Alyson

AU - Queripel,Laura J

AU - Weir,Nicholas W

AU - Bett,Fiona

AU - Divers,Frances

AU - Fairley,Katie

AU - Jacob,Ashok J

AU - Keegan,Edith

AU - White,Tricia

AU - Gemmil,John

AU - Henry,Margo

AU - McGowan,James

AU - Dinnel,Lorraine

AU - Francis,Marc C

AU - Sandeman,Dennis

AU - Yerramasu,Ajay

AU - Berry,Colin

AU - Boylan,Heather

AU - Brown,Ammani

AU - Duffy,Karen

AU - Frood,Alison

AU - Johnstone,Janet

AU - Langhan,Kirsten

AU - Macduff,Ross

AU - MacLeod,Martin

AU - McGlynn,Deborah

AU - McMillan,Nigel

AU - Murdoch,Laura

AU - Noble,Colin

AU - Paterson,Victoria

AU - Steedman,Tracey

AU - Tzemos,Nikolaos

AU - Baird,Andrew

AU - Minns,Fiona C

PY - 2012/10/4

Y1 - 2012/10/4

N2 - ABSTRACT: BACKGROUND: Rapid access chest pain clinics have facilitated the early diagnosis and treatment of patients with coronary heart disease and angina. Despite this important service provision, coronary heart disease continues to be under-diagnosed and many patients are left untreated and at risk. Recent advances in imaging technology have now led to the widespread use of noninvasive computed tomography, which can be used to measure coronary artery calcium scores and perform coronary angiography in one examination. However, this technology has not been robustly evaluated in its application to the clinic.Methods/designThe SCOT-HEART study is an open parallel group prospective multicentre randomized controlled trial of 4,138 patients attending the rapid access chest pain clinic for evaluation of suspected cardiac chest pain. Following clinical consultation, participants will be approached and randomized 1:1 to receive standard care or standard care plus >=64-multidetector computed tomography coronary angiography and coronary calcium score. Randomization will be conducted using a web-based system to ensure allocation concealment and will incorporate minimization. The primary endpoint of the study will be the proportion of patients diagnosed with angina pectoris secondary to coronary heart disease at 6 weeks. Secondary endpoints will include the assessment of subsequent symptoms, diagnosis, investigation and treatment. In addition, long-term health outcomes, safety endpoints, such as radiation dose, and health economic endpoints will be assessed. Assuming a clinic rate of 27.0% for the diagnosis of angina pectoris due to coronary heart disease, we will need to recruit 2,069 patients per group to detect an absolute increase of 4.0% in the rate of diagnosis at 80% power and a two-sided P value of 0.05. The SCOT-HEART study is currently recruiting participants and expects to report in 2014. DISCUSSION: This is the first study to look at the implementation of computed tomography in the patient care pathway that is outcome focused. This study will have major implications for the management of patients with cardiovascular disease.Trial registrationClinicalTrials.gov Identifier: NCT01149590.

AB - ABSTRACT: BACKGROUND: Rapid access chest pain clinics have facilitated the early diagnosis and treatment of patients with coronary heart disease and angina. Despite this important service provision, coronary heart disease continues to be under-diagnosed and many patients are left untreated and at risk. Recent advances in imaging technology have now led to the widespread use of noninvasive computed tomography, which can be used to measure coronary artery calcium scores and perform coronary angiography in one examination. However, this technology has not been robustly evaluated in its application to the clinic.Methods/designThe SCOT-HEART study is an open parallel group prospective multicentre randomized controlled trial of 4,138 patients attending the rapid access chest pain clinic for evaluation of suspected cardiac chest pain. Following clinical consultation, participants will be approached and randomized 1:1 to receive standard care or standard care plus >=64-multidetector computed tomography coronary angiography and coronary calcium score. Randomization will be conducted using a web-based system to ensure allocation concealment and will incorporate minimization. The primary endpoint of the study will be the proportion of patients diagnosed with angina pectoris secondary to coronary heart disease at 6 weeks. Secondary endpoints will include the assessment of subsequent symptoms, diagnosis, investigation and treatment. In addition, long-term health outcomes, safety endpoints, such as radiation dose, and health economic endpoints will be assessed. Assuming a clinic rate of 27.0% for the diagnosis of angina pectoris due to coronary heart disease, we will need to recruit 2,069 patients per group to detect an absolute increase of 4.0% in the rate of diagnosis at 80% power and a two-sided P value of 0.05. The SCOT-HEART study is currently recruiting participants and expects to report in 2014. DISCUSSION: This is the first study to look at the implementation of computed tomography in the patient care pathway that is outcome focused. This study will have major implications for the management of patients with cardiovascular disease.Trial registrationClinicalTrials.gov Identifier: NCT01149590.

U2 - 10.1186/1745-6215-13-184

DO - 10.1186/1745-6215-13-184

M1 - Article

JO - Trials

JF - Trials

VL - 13

ER -

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