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S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation

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S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation. / Fernandez-Sanchez, Maria Elena; Gonatopoulos-Pournatzis, Thomas; Preston, Gavin; Lawlor, Margaret A.; Cowling, Victoria H. (Lead / Corresponding author).

In: Molecular and Cellular Biology, Vol. 29, No. 23, 01.12.2009, p. 6182-6191.

Research output: Contribution to journalArticle

Harvard

Fernandez-Sanchez, ME, Gonatopoulos-Pournatzis, T, Preston, G, Lawlor, MA & Cowling, VH 2009, 'S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation' Molecular and Cellular Biology, vol 29, no. 23, pp. 6182-6191., 10.1128/MCB.00973-09

APA

Fernandez-Sanchez, M. E., Gonatopoulos-Pournatzis, T., Preston, G., Lawlor, M. A., & Cowling, V. H. (2009). S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation. Molecular and Cellular Biology, 29(23), 6182-6191. 10.1128/MCB.00973-09

Vancouver

Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, Cowling VH. S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation. Molecular and Cellular Biology. 2009 Dec 1;29(23):6182-6191. Available from: 10.1128/MCB.00973-09

Author

Fernandez-Sanchez, Maria Elena; Gonatopoulos-Pournatzis, Thomas; Preston, Gavin; Lawlor, Margaret A.; Cowling, Victoria H. (Lead / Corresponding author) / S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation.

In: Molecular and Cellular Biology, Vol. 29, No. 23, 01.12.2009, p. 6182-6191.

Research output: Contribution to journalArticle

Bibtex - Download

@article{ee02e0868f1d492b9e0743354f45f7a0,
title = "S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation",
keywords = "CARBOXY-TERMINAL DOMAIN, POLYMERASE-II, CAPPING ENZYME, C-MYC, ADENOSYLHOMOCYSTEINE HYDROLASE, GENOMIC TARGETS, XENOPUS-LAEVIS, TRANSCRIPTION, METHYLTRANSFERASE, TRANSLATION",
author = "Fernandez-Sanchez, {Maria Elena} and Thomas Gonatopoulos-Pournatzis and Gavin Preston and Lawlor, {Margaret A.} and Cowling, {Victoria H.}",
year = "2009",
doi = "10.1128/MCB.00973-09",
volume = "29",
number = "23",
pages = "6182--6191",
journal = "Molecular and Cellular Biology",
issn = "0270-7306",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation

A1 - Fernandez-Sanchez,Maria Elena

A1 - Gonatopoulos-Pournatzis,Thomas

A1 - Preston,Gavin

A1 - Lawlor,Margaret A.

A1 - Cowling,Victoria H.

AU - Fernandez-Sanchez,Maria Elena

AU - Gonatopoulos-Pournatzis,Thomas

AU - Preston,Gavin

AU - Lawlor,Margaret A.

AU - Cowling,Victoria H.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - <p>The c-Myc proto-oncogene promotes mRNA cap methylation, which is essential for almost all mRNA translation. The mRNA cap methylation reaction produces an inhibitory byproduct, S-adenosyl homocysteine. Here we report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase (SAHH), an enzyme which hydrolyzes S-adenosyl homocysteine, thus neutralizing its inhibitory effects, and this is required for c-Myc-induced mRNA cap methylation. c-Myc-induced mRNA cap methylation was repressed by inhibiting the expression or activity of SAHH, whereas the same treatments did not have a significant effect on c-Myc-induced transcription or other c-Myc-dependent methylation events. The selective inhibition of mRNA cap methylation afforded by SAHH repression revealed that c-Myc-induced cap methylation could be correlated with the core c-Myc functions of protein synthesis, cell proliferation, and cell transformation.</p>

AB - <p>The c-Myc proto-oncogene promotes mRNA cap methylation, which is essential for almost all mRNA translation. The mRNA cap methylation reaction produces an inhibitory byproduct, S-adenosyl homocysteine. Here we report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase (SAHH), an enzyme which hydrolyzes S-adenosyl homocysteine, thus neutralizing its inhibitory effects, and this is required for c-Myc-induced mRNA cap methylation. c-Myc-induced mRNA cap methylation was repressed by inhibiting the expression or activity of SAHH, whereas the same treatments did not have a significant effect on c-Myc-induced transcription or other c-Myc-dependent methylation events. The selective inhibition of mRNA cap methylation afforded by SAHH repression revealed that c-Myc-induced cap methylation could be correlated with the core c-Myc functions of protein synthesis, cell proliferation, and cell transformation.</p>

KW - CARBOXY-TERMINAL DOMAIN

KW - POLYMERASE-II

KW - CAPPING ENZYME

KW - C-MYC

KW - ADENOSYLHOMOCYSTEINE HYDROLASE

KW - GENOMIC TARGETS

KW - XENOPUS-LAEVIS

KW - TRANSCRIPTION

KW - METHYLTRANSFERASE

KW - TRANSLATION

UR - http://www.scopus.com/inward/record.url?scp=71949113286&partnerID=8YFLogxK

U2 - 10.1128/MCB.00973-09

DO - 10.1128/MCB.00973-09

M1 - Article

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

SN - 0270-7306

IS - 23

VL - 29

SP - 6182

EP - 6191

ER -

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