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Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition

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Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition. / Khatua, Biswajit; Ghoshal, Angana; Bhattacharya, Kaushik; Mandal, Chandan; Saha, Bibhuti; Crocker, Paul R.; Mandal, Chitra; Sonnino, Sandro (Editor).

In: FEBS Letters, Vol. 584, No. 3, 05.02.2010, p. 555-561.

Research output: Contribution to journalArticle

Harvard

Khatua, B, Ghoshal, A, Bhattacharya, K, Mandal, C, Saha, B, Crocker, PR, Mandal, C & Sonnino, S (ed.) 2010, 'Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition' FEBS Letters, vol 584, no. 3, pp. 555-561., 10.1016/j.febslet.2009.11.087

APA

Khatua, B., Ghoshal, A., Bhattacharya, K., Mandal, C., Saha, B., Crocker, P. R., ... Sonnino, S. (Ed.) (2010). Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition. FEBS Letters, 584(3), 555-561. 10.1016/j.febslet.2009.11.087

Vancouver

Khatua B, Ghoshal A, Bhattacharya K, Mandal C, Saha B, Crocker PR et al. Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition. FEBS Letters. 2010 Feb 5;584(3):555-561. Available from: 10.1016/j.febslet.2009.11.087

Author

Khatua, Biswajit; Ghoshal, Angana; Bhattacharya, Kaushik; Mandal, Chandan; Saha, Bibhuti; Crocker, Paul R.; Mandal, Chitra; Sonnino, Sandro (Editor) / Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition.

In: FEBS Letters, Vol. 584, No. 3, 05.02.2010, p. 555-561.

Research output: Contribution to journalArticle

Bibtex - Download

@article{3a5e65f1b3f24983b506868ee1c0710a,
title = "Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition",
keywords = "Complement, Sialic acid, Siglec specific recognition, Visceral leishmaniasis, 9-O-acetyl sialic acid, Pseudomonas aeruginosa, Binding, Lipopolysaccharide, Leukocytes",
author = "Biswajit Khatua and Angana Ghoshal and Kaushik Bhattacharya and Chandan Mandal and Bibhuti Saha and Crocker, {Paul R.} and Chitra Mandal and Sandro Sonnino",
year = "2010",
doi = "10.1016/j.febslet.2009.11.087",
volume = "584",
number = "3",
pages = "555--561",
journal = "FEBS Letters",
issn = "0014-5793",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition

A1 - Khatua,Biswajit

A1 - Ghoshal,Angana

A1 - Bhattacharya,Kaushik

A1 - Mandal,Chandan

A1 - Saha,Bibhuti

A1 - Crocker,Paul R.

A1 - Mandal,Chitra

AU - Khatua,Biswajit

AU - Ghoshal,Angana

AU - Bhattacharya,Kaushik

AU - Mandal,Chandan

AU - Saha,Bibhuti

AU - Crocker,Paul R.

AU - Mandal,Chitra

A2 - Sonnino,Sandro

ED - Sonnino,Sandro

PY - 2010/2/5

Y1 - 2010/2/5

N2 - <p>The opportunism of Pseudomonas aeruginosa (PA) in immunocompromised hosts prompted us to explore the potential role of sialic acids (Sia) in this phenomenon. Culture of PA in the presence of exogenous Sia resulted in linkage-specific incorporation of Sia which was associated with decreased complement deposition on the bacteria. Sia acquired by PA mediated enhanced binding of bacteria to recombinant-CHO cells expressing human siglec-7 or siglec-9, as well as to human NK-cells and monocytes naturally expressing these siglecs. Therefore, Sia may be acquired by PA in the host and contribute to bacterial pathogenicity and host-cell interactions via reduction of complement deposition and siglec-dependent recognition. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</p>

AB - <p>The opportunism of Pseudomonas aeruginosa (PA) in immunocompromised hosts prompted us to explore the potential role of sialic acids (Sia) in this phenomenon. Culture of PA in the presence of exogenous Sia resulted in linkage-specific incorporation of Sia which was associated with decreased complement deposition on the bacteria. Sia acquired by PA mediated enhanced binding of bacteria to recombinant-CHO cells expressing human siglec-7 or siglec-9, as well as to human NK-cells and monocytes naturally expressing these siglecs. Therefore, Sia may be acquired by PA in the host and contribute to bacterial pathogenicity and host-cell interactions via reduction of complement deposition and siglec-dependent recognition. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</p>

KW - Complement

KW - Sialic acid

KW - Siglec specific recognition

KW - Visceral leishmaniasis

KW - 9-O-acetyl sialic acid

KW - Pseudomonas aeruginosa

KW - Binding

KW - Lipopolysaccharide

KW - Leukocytes

U2 - 10.1016/j.febslet.2009.11.087

DO - 10.1016/j.febslet.2009.11.087

M1 - Article

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 3

VL - 584

SP - 555

EP - 561

ER -

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