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Snf2 family ATPases and DExx box helicases

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Snf2 family ATPases and DExx box helicases : differences and unifying concepts from high-resolution crystal structures. / Dürr, Harald; Flaus, Andrew; Owen-Hughes, Tom; Hopfner, Karl-Peter.

In: Nucleic Acids Research, Vol. 34, No. 15, 2006, p. 4160-7.

Research output: Contribution to journalArticle

Harvard

Dürr, H, Flaus, A, Owen-Hughes, T & Hopfner, K-P 2006, 'Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures' Nucleic Acids Research, vol 34, no. 15, pp. 4160-7.

APA

Dürr, H., Flaus, A., Owen-Hughes, T., & Hopfner, K-P. (2006). Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures. Nucleic Acids Research, 34(15), 4160-7doi: 10.1093/nar/gkl540

Vancouver

Dürr H, Flaus A, Owen-Hughes T, Hopfner K-P. Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures. Nucleic Acids Research. 2006;34(15):4160-7.

Author

Dürr, Harald; Flaus, Andrew; Owen-Hughes, Tom; Hopfner, Karl-Peter / Snf2 family ATPases and DExx box helicases : differences and unifying concepts from high-resolution crystal structures.

In: Nucleic Acids Research, Vol. 34, No. 15, 2006, p. 4160-7.

Research output: Contribution to journalArticle

Bibtex - Download

@article{9476ddd41a1c45b98f570b85eb22297e,
title = "Snf2 family ATPases and DExx box helicases",
author = "Harald Dürr and Andrew Flaus and Tom Owen-Hughes and Karl-Peter Hopfner",
year = "2006",
volume = "34",
number = "15",
pages = "4160--7",
journal = "Nucleic Acids Research",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Snf2 family ATPases and DExx box helicases

T2 - differences and unifying concepts from high-resolution crystal structures

A1 - Dürr,Harald

A1 - Flaus,Andrew

A1 - Owen-Hughes,Tom

A1 - Hopfner,Karl-Peter

AU - Dürr,Harald

AU - Flaus,Andrew

AU - Owen-Hughes,Tom

AU - Hopfner,Karl-Peter

PY - 2006

Y1 - 2006

N2 - Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA-protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases, yet they do not possess helicase activity. Recent biochemical and structural studies suggest that the mechanism by which these enzymes act involves ATP-dependent translocation on DNA. Crystal structures suggest that these enzymes travel along the minor groove, a process that can generate the torque or energy in remodelling processes. We review the recent structural and biochemical findings which suggest a common mechanistic basis underlies the action of many of both Snf2 family and DExx box helicases.

AB - Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA-protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases, yet they do not possess helicase activity. Recent biochemical and structural studies suggest that the mechanism by which these enzymes act involves ATP-dependent translocation on DNA. Crystal structures suggest that these enzymes travel along the minor groove, a process that can generate the torque or energy in remodelling processes. We review the recent structural and biochemical findings which suggest a common mechanistic basis underlies the action of many of both Snf2 family and DExx box helicases.

UR - http://ukpmc.ac.uk/articles/PMC1616948

U2 - 10.1093/nar/gkl540

DO - 10.1093/nar/gkl540

M1 - Article

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 15

VL - 34

SP - 4160

EP - 4167

ER -

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