Snf2 family ATPases and DExx box helicases : differences and unifying concepts from high-resolution crystal structures. / Dürr, Harald; Flaus, Andrew; Owen-Hughes, Tom; Hopfner, Karl-Peter.
In: Nucleic Acids Research, Vol. 34, No. 15, 2006, p. 4160-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Snf2 family ATPases and DExx box helicases
T2 - differences and unifying concepts from high-resolution crystal structures
A1 - Dürr,Harald
A1 - Flaus,Andrew
A1 - Owen-Hughes,Tom
A1 - Hopfner,Karl-Peter
AU - Dürr,Harald
AU - Flaus,Andrew
AU - Owen-Hughes,Tom
AU - Hopfner,Karl-Peter
PY - 2006
Y1 - 2006
N2 - Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA-protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases, yet they do not possess helicase activity. Recent biochemical and structural studies suggest that the mechanism by which these enzymes act involves ATP-dependent translocation on DNA. Crystal structures suggest that these enzymes travel along the minor groove, a process that can generate the torque or energy in remodelling processes. We review the recent structural and biochemical findings which suggest a common mechanistic basis underlies the action of many of both Snf2 family and DExx box helicases.
AB - Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA-protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases, yet they do not possess helicase activity. Recent biochemical and structural studies suggest that the mechanism by which these enzymes act involves ATP-dependent translocation on DNA. Crystal structures suggest that these enzymes travel along the minor groove, a process that can generate the torque or energy in remodelling processes. We review the recent structural and biochemical findings which suggest a common mechanistic basis underlies the action of many of both Snf2 family and DExx box helicases.
UR - http://ukpmc.ac.uk/articles/PMC1616948
U2 - 10.1093/nar/gkl540
DO - 10.1093/nar/gkl540
M1 - Article
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - 15
VL - 34
SP - 4160
EP - 4167
ER -
251 KB, PDF-document