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Sperm are promiscuous and CatSper is to blame...

Sperm are promiscuous and CatSper is to blame...

Research output: Contribution to journalArticle

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  • Christopher L. R. Barratt
  • Stephen J. Publicover

Research units


Original languageEnglish
Pages (from-to)1624-1626
Number of pages3
JournalEMBO Journal
Issue number7
StatePublished - 4 Apr 2012


A sperm-specific cation channel (CatSper) facilitates the entry of calcium necessary for rapid changes in sperm motility allowing the cell to navigate the hurdles of the female reproductive tract and successfully to locate the egg. Brenker and colleagues show that CatSper is (directly) activated by a diverse range of small organic molecules that are reported to evoke chemotaxis in human spermatozoa, suggesting that CatSper may function as a polymodal, chemosensory calcium channel. Additionally, they provide strong evidence that calcium entry into the spermatozoon does not employ specific, G protein-coupled odorant receptors or activation of trans-membrane adenylate cyclase and is not induced by cyclic nucleotides.



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