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The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine

The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine

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Authors

  • Daniel T. Baptista-Hon
  • Tarek Z. Deeb
  • Nidaa A. Othman
  • Douglas Sharp
  • Tim G. Hales (Lead / Corresponding author)

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Info

Original languageEnglish
Pages693-704
Number of pages12
JournalBritish Journal of Pharmacology
Journal publication date2012
Volume165
Issue3
DOIs
StatePublished

Abstract

Morphine is an antagonist at 5-HT(3) A receptors. 5-HT(3) and opioid receptors are expressed in many of the same neuronal pathways where they modulate gut motility, pain and reinforcement. There is increasing interest in the 5-HT3B subunit, which confers altered pharmacology to 5-HT(3) receptors. We investigated the mechanisms of inhibition by morphine of 5-HT(3) receptors and the influence of the 5-HT3B subunit.

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