The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine
Research output: Contribution to journal › Article
- Daniel T. Baptista-Hon
- Tarek Z. Deeb
- Nidaa A. Othman
- Douglas Sharp
- Tim G. Hales
| Original language | English |
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| Number of pages | 12 |
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| Pages | 693-704 |
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| Journal | British Journal of Pharmacology |
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| Journal publication date | 2012 |
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| Journal number | 3 |
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| Volume | 165 |
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| DOIs | |
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| State | Published |
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Morphine is an antagonist at 5-HT(3) A receptors. 5-HT(3) and opioid receptors are expressed in many of the same neuronal pathways where they modulate gut motility, pain and reinforcement. There is increasing interest in the 5-HT3B subunit, which confers altered pharmacology to 5-HT(3) receptors. We investigated the mechanisms of inhibition by morphine of 5-HT(3) receptors and the influence of the 5-HT3B subunit.