The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma : insights into the genesis of an unusual tumour. / Oparka, Richard; Cassidy, Andrew; Reilly, Stephanie; Stenhouse, Alasdair; McCluggage, W. Glenn; Herrington, C. Simon.
In: Histopathology, Vol. 60, No. 5, 04.2012, p. 838-842.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The C134W (402 C > G) FOXL2 mutation is absent in ovarian gynandroblastoma
T2 - insights into the genesis of an unusual tumour
A1 - Oparka,Richard
A1 - Cassidy,Andrew
A1 - Reilly,Stephanie
A1 - Stenhouse,Alasdair
A1 - McCluggage,W. Glenn
A1 - Herrington,C. Simon
AU - Oparka,Richard
AU - Cassidy,Andrew
AU - Reilly,Stephanie
AU - Stenhouse,Alasdair
AU - McCluggage,W. Glenn
AU - Herrington,C. Simon
PY - 2012/4
Y1 - 2012/4
N2 - <p>Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.</p><p>Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.</p><p>Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.</p>
AB - <p>Aims: Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combinationof components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C> G) FOXL2 mutation and adult- type GCT, we analysed a series of gynandroblastomas for this mutation.</p><p>Methods and results: Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C> G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST / SLT component of six cases, three of which contained adult- type GCT.</p><p>Conclusions: This suggests that, despite their similar morphological appearances, the GCT- like component of gynandroblastoma has a different molecular basis from conventional adult- type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.</p>
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84858999473&md5=795b82ef33f11ffad396a3df663f036c
U2 - 10.1111/j.1365-2559.2011.04148.x
DO - 10.1111/j.1365-2559.2011.04148.x
M1 - Article
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 5
VL - 60
SP - 838
EP - 842
ER -