The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid

NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE PUBLISHER’S WEBSITE FOR AN ACCURATE DISPLAY Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CH CH(CH2)7CH3, and 2, R=(CH2)7CH CHCH2CH CH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.