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The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid

The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid

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Authors

  • Dmitry V. Yashunsky
  • Vladimir S. Borodkin
  • Michael A. J. Ferguson
  • Andrei V. Nikolaev

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Info

Original languageEnglish
Pages468-474
Number of pages7
JournalAngewandte Chemie International Edition
Journal publication date2006
Journal number3
Volume45
DOIs
StatePublished

Abstract

NOTE: THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO THE PUBLISHER’S WEBSITE FOR AN ACCURATE DISPLAY Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CH CH(CH2)7CH3, and 2, R=(CH2)7CH CHCH2CH CH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.

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