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The coordination of T-cell function by serine/threonine kinases

The coordination of T-cell function by serine/threonine kinases

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Original languageEnglish
Article numbera002261
Pages-
Number of pages10
JournalCold Spring Harbor Perspectives in Biology
Journal publication dateJan 2011
Volume3
Issue1
DOIs
StatePublished

Abstract

The function of T-lymphocytes during adaptive immune responses is directed by antigen receptors, costimulatory molecules, and cytokines. These extrinsic stimuli are coupled to a network of serine/threonine kinases that control the epigenetic, transcriptional, and metabolic programs that determine T-cell function. It is increasingly recognized that serine/threonine kinases, notably those that are controlled by lipid second messengers such as polyunsaturated diacylglycerols (DAG) and phosphatidylinositol-(3,4,5)-trisphosphate (PIP3), are at the core of T-cell signal transduction. In the present review the object will be to discuss some important examples of how pathways of serine/threonine phosphorylation control molecular functions of proteins and control protein localization to coordinate T-cell function in adaptive immune responses.

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